{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/20866"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/20866","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Manganese utilization as affected by excess calcium and phosphorus","abstract":"Different experimental approaches were undertaken to evaluate the effect of excess Ca and P on Mn utilization. Chick bioassays were conducted to assess the effects of various sources and varying levels and combinations of excess dietary Ca and P on Mn bioavailability. The regression of total tibia Mn on supplemental Mn intake was done according to a standard curve procedure in the first set of experiments, and a slope-ratio multiple-regression approach was used in the second set of experiments. Feeding.88% excess P, regardless of source and irrespective of whether fed alone or in combination with excess Ca, reduced Mn utilization by 50 to 65%. Calcium sources caused only slight reductions (ie., 0 to 15%) in Mn utilization. Relative to the standard (no added P).22,.44 and.88% excess P reduced Mn utilization by 16, 22, and 31%, respectively, in a second set of experiments. Total tibia Mn was not depressed by excess Ca in these trials. A repletion-depletion assay was conducted to evaluate the effect of excess P and Mn status on Mn excretion and turnover. Chicks were fed either 30 mg Mn/kg or 1000 mg Mn/kg in casein-dextrose diets for 7 d. Following this loading period, birds were fed a Mn-deficient casein-dextrose diet (1.4 mg Mn/kg) in the presence or absence of.5% excess P supplied from dicalcium phosphate. Changes in whole body and selected body-tissue Mn were determined over the 20-d depletion period. All tissues showed significantly reduced biological half-lives as a result of increased Mn status, but were not affected by excess P. To evaluate the effect of excess Ca or P on endogenous fecal Mn excretion and true Mn absorption, two balance studies with growing chicks were conducted. An isotope-dilution technique utilizing $\\sp{54}$Mn, was used to estimate endogenous Mn in excreta. True absorption of Mn was not affected by excess Ca but was adversely affected by excess P. In birds fed 137 mg Mn/kg, absorption of Mn decreased 22% as excess P increased from 0 to.8%, whereas in birds fed 1037 mg Mn/kg, absorption of Mn decreased 59% as P level increased. The above results indicate that Mn utilization is not affected by excess Ca but is markedly reduced by excess dietary P.","abstract_html":"Different experimental approaches were undertaken to evaluate the effect of excess Ca and P on Mn utilization. Chick bioassays were conducted to assess the effects of various sources and varying levels and combinations of excess dietary Ca and P on Mn bioavailability. The regression of total tibia Mn on supplemental Mn intake was done according to a standard curve procedure in the first set of experiments, and a slope-ratio multiple-regression approach was used in the second set of experiments. Feeding.88% excess P, regardless of source and irrespective of whether fed alone or in combination with excess Ca, reduced Mn utilization by 50 to 65%. Calcium sources caused only slight reductions (ie., 0 to 15%) in Mn utilization. Relative to the standard (no added P).22,.44 and.88% excess P reduced Mn utilization by 16, 22, and 31%, respectively, in a second set of experiments. Total tibia Mn was not depressed by excess Ca in these trials. A repletion-depletion assay was conducted to evaluate the effect of excess P and Mn status on Mn excretion and turnover. Chicks were fed either 30 mg Mn/kg or 1000 mg Mn/kg in casein-dextrose diets for 7 d. Following this loading period, birds were fed a Mn-deficient casein-dextrose diet (1.4 mg Mn/kg) in the presence or absence of.5% excess P supplied from dicalcium phosphate. Changes in whole body and selected body-tissue Mn were determined over the 20-d depletion period. All tissues showed significantly reduced biological half-lives as a result of increased Mn status, but were not affected by excess P. To evaluate the effect of excess Ca or P on endogenous fecal Mn excretion and true Mn absorption, two balance studies with growing chicks were conducted. An isotope-dilution technique utilizing $\\sp{54}$Mn, was used to estimate endogenous Mn in excreta. True absorption of Mn was not affected by excess Ca but was adversely affected by excess P. In birds fed 137 mg Mn/kg, absorption of Mn decreased 22% as excess P increased from 0 to.8%, whereas in birds fed 1037 mg Mn/kg, absorption of Mn decreased 59% as P level increased. The above results indicate that Mn utilization is not affected by excess Ca but is markedly reduced by excess dietary P.","abstract_has_math":true,"creators":["Wedekind, Karen J."],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Animal Sciences","degree_department":null,"school":null,"contributors":["Baker, David H."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011-05-07T12:51:35Z","date_published":"2011-05-07T12:51:35Z","updated_at":"2026-07-22T22:25:16Z","subjects":["Agriculture, Animal Culture and Nutrition","Health Sciences, Nutrition"],"languages":["eng"],"rights":["Copyright 1990 Wedekind, Karen J."],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["AAI9114455","(UMI)AAI9114455"],"render_values":[{"text":"AAI9114455","href":null,"code":true},{"text":"(UMI)AAI9114455","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/20866","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Baker, David H."]},{"key":"dc:creator","label":"Author","values":["Wedekind, Karen J."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2011-05-07T12:51:35Z","10000-01-01","1990"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Animal Sciences"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Agriculture, Animal Culture and Nutrition","Health Sciences, Nutrition"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 1990 Wedekind, Karen J."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["AAI9114455","(UMI)AAI9114455","http://hdl.handle.net/2142/20866"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Different experimental approaches were undertaken to evaluate the effect of excess Ca and P on Mn utilization. Chick bioassays were conducted to assess the effects of various sources and varying levels and combinations of excess dietary Ca and P on Mn bioavailability. The regression of total tibia Mn on supplemental Mn intake was done according to a standard curve procedure in the first set of experiments, and a slope-ratio multiple-regression approach was used in the second set of experiments. Feeding.88% excess P, regardless of source and irrespective of whether fed alone or in combination with excess Ca, reduced Mn utilization by 50 to 65%. Calcium sources caused only slight reductions (ie., 0 to 15%) in Mn utilization. Relative to the standard (no added P).22,.44 and.88% excess P reduced Mn utilization by 16, 22, and 31%, respectively, in a second set of experiments. Total tibia Mn was not depressed by excess Ca in these trials. A repletion-depletion assay was conducted to evaluate the effect of excess P and Mn status on Mn excretion and turnover. Chicks were fed either 30 mg Mn/kg or 1000 mg Mn/kg in casein-dextrose diets for 7 d. Following this loading period, birds were fed a Mn-deficient casein-dextrose diet (1.4 mg Mn/kg) in the presence or absence of.5% excess P supplied from dicalcium phosphate. Changes in whole body and selected body-tissue Mn were determined over the 20-d depletion period. All tissues showed significantly reduced biological half-lives as a result of increased Mn status, but were not affected by excess P. To evaluate the effect of excess Ca or P on endogenous fecal Mn excretion and true Mn absorption, two balance studies with growing chicks were conducted. An isotope-dilution technique utilizing $\\sp{54}$Mn, was used to estimate endogenous Mn in excreta. True absorption of Mn was not affected by excess Ca but was adversely affected by excess P. In birds fed 137 mg Mn/kg, absorption of Mn decreased 22% as excess P increased from 0 to.8%, whereas in birds fed 1037 mg Mn/kg, absorption of Mn decreased 59% as P level increased. The above results indicate that Mn utilization is not affected by excess Ca but is markedly reduced by excess dietary P.","Made available in DSpace on 2011-05-07T12:51:35Z (GMT). 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Chick bioassays were conducted to assess the effects of various sources and varying levels and combinations of excess dietary Ca and P on Mn bioavailability. The regression of total tibia Mn on supplemental Mn intake was done according to a standard curve procedure in the first set of experiments, and a slope-ratio multiple-regression approach was used in the second set of experiments. Feeding.88% excess P, regardless of source and irrespective of whether fed alone or in combination with excess Ca, reduced Mn utilization by 50 to 65%. Calcium sources caused only slight reductions (ie., 0 to 15%) in Mn utilization. Relative to the standard (no added P).22,.44 and.88% excess P reduced Mn utilization by 16, 22, and 31%, respectively, in a second set of experiments. Total tibia Mn was not depressed by excess Ca in these trials. A repletion-depletion assay was conducted to evaluate the effect of excess P and Mn status on Mn excretion and turnover. Chicks were fed either 30 mg Mn/kg or 1000 mg Mn/kg in casein-dextrose diets for 7 d. Following this loading period, birds were fed a Mn-deficient casein-dextrose diet (1.4 mg Mn/kg) in the presence or absence of.5% excess P supplied from dicalcium phosphate. Changes in whole body and selected body-tissue Mn were determined over the 20-d depletion period. All tissues showed significantly reduced biological half-lives as a result of increased Mn status, but were not affected by excess P. To evaluate the effect of excess Ca or P on endogenous fecal Mn excretion and true Mn absorption, two balance studies with growing chicks were conducted. An isotope-dilution technique utilizing $\\sp{54}$Mn, was used to estimate endogenous Mn in excreta. True absorption of Mn was not affected by excess Ca but was adversely affected by excess P. In birds fed 137 mg Mn/kg, absorption of Mn decreased 22% as excess P increased from 0 to.8%, whereas in birds fed 1037 mg Mn/kg, absorption of Mn decreased 59% as P level increased. The above results indicate that Mn utilization is not affected by excess Ca but is markedly reduced by excess dietary P.","Made available in DSpace on 2011-05-07T12:51:35Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9114455.pdf: 4703585 bytes, checksum: 38030658aa4184042475b5527ae7a1dd (MD5) Previous issue date: 1990","Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T14:46:49Z Item is restricted indefinitely.","Restriction data tranferred 2014-07-01T11:21:04-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission","ETDs are only available to UIUC Users without author permission","U of I Only"],"dc:identifier":["AAI9114455","(UMI)AAI9114455","http://hdl.handle.net/2142/20866"],"dc:language":["eng"],"dc:rights":["Copyright 1990 Wedekind, Karen J."],"dc:subject":["Agriculture, Animal Culture and Nutrition","Health Sciences, Nutrition"],"dc:title":["Manganese utilization as affected by excess calcium and phosphorus"],"dc:type":["text"],"thesis:degree_discipline":["Animal Sciences"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:25:16Z"}