{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/20800"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/20800","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"The genetic basis of persistence and recovery in stuttering","abstract":"The purpose of this study was to elaborate on genetic perspectives of stuttering with reference to recovery and chronicity in children. Past research has provided evidence of a genetic factor in the transmission of susceptibility to stuttering, but factors governing persistence and recovery have not been as yet identified.","abstract_html":"The purpose of this study was to elaborate on genetic perspectives of stuttering with reference to recovery and chronicity in children. Past research has provided evidence of a genetic factor in the transmission of susceptibility to stuttering, but factors governing persistence and recovery have not been as yet identified.","abstract_has_math":false,"creators":["Ambrose, Nicoline Grinager"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Speech and Hearing Science","degree_department":null,"school":null,"contributors":["Yairi, Ehud"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011-05-07T12:49:38Z","date_published":"2011-05-07T12:49:38Z","updated_at":"2026-07-22T22:25:16Z","subjects":["Biology, Genetics","Health Sciences, Rehabilitation and Therapy","Health Sciences, Speech Pathology"],"languages":["eng"],"rights":["Copyright 1996 Ambrose, Nicoline Grinager"],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["9780591087703","AAI9702444","(UMI)AAI9702444"],"render_values":[{"text":"9780591087703","href":null,"code":true},{"text":"AAI9702444","href":null,"code":true},{"text":"(UMI)AAI9702444","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/20800","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Yairi, Ehud"]},{"key":"dc:creator","label":"Author","values":["Ambrose, Nicoline Grinager"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2011-05-07T12:49:38Z","10000-01-01","1996"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Speech and Hearing Science"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Biology, Genetics","Health Sciences, Rehabilitation and Therapy","Health Sciences, Speech Pathology"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 1996 Ambrose, Nicoline Grinager"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["9780591087703","AAI9702444","(UMI)AAI9702444","http://hdl.handle.net/2142/20800"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The purpose of this study was to elaborate on genetic perspectives of stuttering with reference to recovery and chronicity in children. Past research has provided evidence of a genetic factor in the transmission of susceptibility to stuttering, but factors governing persistence and recovery have not been as yet identified.","Immediate and extended families of 66 stuttering probands were investigated to determine frequencies of persistent and recovered stuttering. Pedigree analysis and segregation analysis were utilized to examine patterns of heritability.","The following questions were investigated: (1) Is there a sex effect in recovery from stuttering? This hypothesis examined the notion that females have a greater chance of recovery than do males, leading to the changing sex ratio from approximately 2:1 males to females close to onset of the disorder, to 4 or 5:1 in adulthood. A significant chi square indicated that recovery among females is significantly more frequent than among males, as shown by the sharply different sex ratios of persistent vs. recovered stutterers. (2) Is persistence or recovery from stuttering heritable? If recovery appears to be heritable, (a) are recovered and persistent stuttering a unitary disorder where recovered stuttering is a genetically milder form of persistent stuttering; (b) is recovery transmitted independent of stuttering; or (c) are recovered and persistent stuttering independent disorders? Results indicated that persistence or recovery are indeed heritable, and further, that recovery is not a milder form, nor do the two types of stuttering appear to be unrelated, independent disorders. Data are most consistent with the hypothesis that persistence is in part due to an additional genetic factor.","Segregation analyses supported these conclusions and provided statistical evidence for both a single major locus and polygenic component for persistent and recovered stuttering.","This study was supported by grant #R01-DC00459 from the National Institute of Deafness and Other Communication Disorders, National Institutes of Health, Principal Investigator: Ehud Yairi.","Made available in DSpace on 2011-05-07T12:49:38Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9702444.pdf: 5471726 bytes, checksum: 7bf453d049deda2d40d7c476bc34ae4c (MD5) Previous issue date: 1996","Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T14:46:21Z Item is restricted indefinitely.","Restriction data tranferred 2014-07-01T11:20:45-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission","ETDs are only available to UIUC Users without author permission","U of I Only"]},{"key":"dc:title","label":"Title","values":["The genetic basis of persistence and recovery in stuttering"]}]}],"canonical_facts":{"dc:contributor":["Yairi, Ehud"],"dc:creator":["Ambrose, Nicoline Grinager"],"dc:date":["2011-05-07T12:49:38Z","10000-01-01","1996"],"dc:description":["The purpose of this study was to elaborate on genetic perspectives of stuttering with reference to recovery and chronicity in children. Past research has provided evidence of a genetic factor in the transmission of susceptibility to stuttering, but factors governing persistence and recovery have not been as yet identified.","Immediate and extended families of 66 stuttering probands were investigated to determine frequencies of persistent and recovered stuttering. Pedigree analysis and segregation analysis were utilized to examine patterns of heritability.","The following questions were investigated: (1) Is there a sex effect in recovery from stuttering? This hypothesis examined the notion that females have a greater chance of recovery than do males, leading to the changing sex ratio from approximately 2:1 males to females close to onset of the disorder, to 4 or 5:1 in adulthood. A significant chi square indicated that recovery among females is significantly more frequent than among males, as shown by the sharply different sex ratios of persistent vs. recovered stutterers. (2) Is persistence or recovery from stuttering heritable? If recovery appears to be heritable, (a) are recovered and persistent stuttering a unitary disorder where recovered stuttering is a genetically milder form of persistent stuttering; (b) is recovery transmitted independent of stuttering; or (c) are recovered and persistent stuttering independent disorders? Results indicated that persistence or recovery are indeed heritable, and further, that recovery is not a milder form, nor do the two types of stuttering appear to be unrelated, independent disorders. Data are most consistent with the hypothesis that persistence is in part due to an additional genetic factor.","Segregation analyses supported these conclusions and provided statistical evidence for both a single major locus and polygenic component for persistent and recovered stuttering.","This study was supported by grant #R01-DC00459 from the National Institute of Deafness and Other Communication Disorders, National Institutes of Health, Principal Investigator: Ehud Yairi.","Made available in DSpace on 2011-05-07T12:49:38Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9702444.pdf: 5471726 bytes, checksum: 7bf453d049deda2d40d7c476bc34ae4c (MD5) Previous issue date: 1996","Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T14:46:21Z Item is restricted indefinitely.","Restriction data tranferred 2014-07-01T11:20:45-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission","ETDs are only available to UIUC Users without author permission","U of I Only"],"dc:identifier":["9780591087703","AAI9702444","(UMI)AAI9702444","http://hdl.handle.net/2142/20800"],"dc:language":["eng"],"dc:rights":["Copyright 1996 Ambrose, Nicoline Grinager"],"dc:subject":["Biology, Genetics","Health Sciences, Rehabilitation and Therapy","Health Sciences, Speech Pathology"],"dc:title":["The genetic basis of persistence and recovery in stuttering"],"dc:type":["text"],"thesis:degree_discipline":["Speech and Hearing Science"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:25:16Z"}