{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/20789"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/20789","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Follicle stimulating hormone and steroidogenesis in ovarian granulosa cells during aging in the domestic hen","abstract":"There is a decreased rate of follicular maturation with age in the domestic hen. The time required for follicular growth increases, while the number of growing follicles decreases. The causes for this physiological change with age are not defined. Perhaps there are changes with age in the responsiveness of ovarian follicles to gonadotropins.","abstract_html":"There is a decreased rate of follicular maturation with age in the domestic hen. The time required for follicular growth increases, while the number of growing follicles decreases. The causes for this physiological change with age are not defined. Perhaps there are changes with age in the responsiveness of ovarian follicles to gonadotropins.","abstract_has_math":false,"creators":["Palmer, Stephen Sunderland"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Animal Sciences","degree_department":null,"school":null,"contributors":["Bahr, Janice M."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011-05-07T12:49:19Z","date_published":"2011-05-07T12:49:19Z","updated_at":"2026-07-22T22:25:16Z","subjects":["Biology, General","Biology, Animal Physiology","Agriculture, Animal Culture and Nutrition"],"languages":["eng"],"rights":["Copyright 1989 Palmer, Stephen Sunderland"],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["AAI9010977","(UMI)AAI9010977"],"render_values":[{"text":"AAI9010977","href":null,"code":true},{"text":"(UMI)AAI9010977","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/20789","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Bahr, Janice M."]},{"key":"dc:creator","label":"Author","values":["Palmer, Stephen Sunderland"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2011-05-07T12:49:19Z","10000-01-01","1989"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Animal Sciences"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Biology, General","Biology, Animal Physiology","Agriculture, Animal Culture and Nutrition"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 1989 Palmer, Stephen Sunderland"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["AAI9010977","(UMI)AAI9010977","http://hdl.handle.net/2142/20789"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["There is a decreased rate of follicular maturation with age in the domestic hen. The time required for follicular growth increases, while the number of growing follicles decreases. The causes for this physiological change with age are not defined. Perhaps there are changes with age in the responsiveness of ovarian follicles to gonadotropins.","The goal of this thesis was to determine if the responsiveness of the granulosa cells from the preovulatory follicles of the hen to FSH changes with age. The specific aims were to determine in granulosa layers of preovulatory follicles from young and old hens: (1) number of FSH receptors and progesterone (P$\\sb4$) production in response to FSH; (2) amount of P$\\sb{450}$ cholesterol side chain cleavage enzyme (P$\\sb{450}$scc); and (3) effect of subcutaneous injections of FSH for 5 days on the pattern of follicular growth, number of FSH receptors and amount of P$\\sb{450}$scc enzyme.","Granulosa cells from the 4 largest follicles of old hens compared to cells from young hens had more FSH receptors and produced more P$\\sb4$ in the presence of FSH. Production of pregnenolone (P$\\sb5$) and P$\\sb4$ by granulosa cells in response to 8-bromo-cAMP did not differ with age. However, granulosa cells from the follicles of young hens compared to old hens had a greater amount of P$\\sb{450}$scc enzyme. Exogenous FSH treatment caused a dose dependent increase in serum estradiol concentrations, yolk formation, and number of normal small follicles in the ovary. Granulosa layers from FSH treated hens compared to layers from saline injected hens had more P$\\sb{450}$scc enzyme as detected by Western blots.","Follicles from old hens compared to follicles from young hens were less mature because they remained longer in an FSH dominated phase of follicular growth. The exogenous FSH treatment of old hens may have increased the rate of follicular growth and maturation because the endogenous secretion of FSH in old hens was inappropriate.","Made available in DSpace on 2011-05-07T12:49:19Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9010977.pdf: 4833374 bytes, checksum: ad4bdeb9edf16399b4269425787b7355 (MD5) Previous issue date: 1989","Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T14:46:17Z Item is restricted indefinitely.","Restriction data tranferred 2014-07-01T11:20:41-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission","ETDs are only available to UIUC Users without author permission","U of I Only"]},{"key":"dc:title","label":"Title","values":["Follicle stimulating hormone and steroidogenesis in ovarian granulosa cells during aging in the domestic hen"]}]}],"canonical_facts":{"dc:contributor":["Bahr, Janice M."],"dc:creator":["Palmer, Stephen Sunderland"],"dc:date":["2011-05-07T12:49:19Z","10000-01-01","1989"],"dc:description":["There is a decreased rate of follicular maturation with age in the domestic hen. The time required for follicular growth increases, while the number of growing follicles decreases. The causes for this physiological change with age are not defined. Perhaps there are changes with age in the responsiveness of ovarian follicles to gonadotropins.","The goal of this thesis was to determine if the responsiveness of the granulosa cells from the preovulatory follicles of the hen to FSH changes with age. The specific aims were to determine in granulosa layers of preovulatory follicles from young and old hens: (1) number of FSH receptors and progesterone (P$\\sb4$) production in response to FSH; (2) amount of P$\\sb{450}$ cholesterol side chain cleavage enzyme (P$\\sb{450}$scc); and (3) effect of subcutaneous injections of FSH for 5 days on the pattern of follicular growth, number of FSH receptors and amount of P$\\sb{450}$scc enzyme.","Granulosa cells from the 4 largest follicles of old hens compared to cells from young hens had more FSH receptors and produced more P$\\sb4$ in the presence of FSH. Production of pregnenolone (P$\\sb5$) and P$\\sb4$ by granulosa cells in response to 8-bromo-cAMP did not differ with age. However, granulosa cells from the follicles of young hens compared to old hens had a greater amount of P$\\sb{450}$scc enzyme. Exogenous FSH treatment caused a dose dependent increase in serum estradiol concentrations, yolk formation, and number of normal small follicles in the ovary. Granulosa layers from FSH treated hens compared to layers from saline injected hens had more P$\\sb{450}$scc enzyme as detected by Western blots.","Follicles from old hens compared to follicles from young hens were less mature because they remained longer in an FSH dominated phase of follicular growth. The exogenous FSH treatment of old hens may have increased the rate of follicular growth and maturation because the endogenous secretion of FSH in old hens was inappropriate.","Made available in DSpace on 2011-05-07T12:49:19Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9010977.pdf: 4833374 bytes, checksum: ad4bdeb9edf16399b4269425787b7355 (MD5) Previous issue date: 1989","Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T14:46:17Z Item is restricted indefinitely.","Restriction data tranferred 2014-07-01T11:20:41-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission","ETDs are only available to UIUC Users without author permission","U of I Only"],"dc:identifier":["AAI9010977","(UMI)AAI9010977","http://hdl.handle.net/2142/20789"],"dc:language":["eng"],"dc:rights":["Copyright 1989 Palmer, Stephen Sunderland"],"dc:subject":["Biology, General","Biology, Animal Physiology","Agriculture, Animal Culture and Nutrition"],"dc:title":["Follicle stimulating hormone and steroidogenesis in ovarian granulosa cells during aging in the domestic hen"],"dc:type":["text"],"thesis:degree_discipline":["Animal Sciences"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:25:16Z"}