{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/20625"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/20625","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Asymmetric catalytic epoxidations of simple olefins","abstract":"Two types of chiral (salen)Mn(III) complexes, either cationic or neutral, were synthesized by complexation of the corresponding chiral salen ligands with manganese salt. Neutral Mn(III) salen complexes were prepared from the ligands and $\\rm Mn(OAc)\\sb2{\\cdot}4H\\sb2O$ via in situ aerial oxidation of the corresponding (salen)Mn(II) species. This approach circumvents the manipulation of highly air sensitive Mn(II) salen intermediates. The use of commercially available bleach solution as the oxidant greatly increases the practical value of this asymmetric epoxidation process.","abstract_html":"Two types of chiral (salen)Mn(III) complexes, either cationic or neutral, were synthesized by complexation of the corresponding chiral salen ligands with manganese salt. Neutral Mn(III) salen complexes were prepared from the ligands and $\\rm Mn(OAc)\\sb2{\\cdot}4H\\sb2O$ via in situ aerial oxidation of the corresponding (salen)Mn(II) species. This approach circumvents the manipulation of highly air sensitive Mn(II) salen intermediates. The use of commercially available bleach solution as the oxidant greatly increases the practical value of this asymmetric epoxidation process.","abstract_has_math":true,"creators":["Zhang, Wei"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Chemistry","degree_department":null,"school":null,"contributors":["Jacobsen, Eric N."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011-05-07T12:44:38Z","date_published":"2011-05-07T12:44:38Z","updated_at":"2026-07-22T22:25:16Z","subjects":["Chemistry, Organic"],"languages":["eng"],"rights":["Copyright 1991 Zhang, Wei"],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["(UMI)AAI9211057","AAI9211057"],"render_values":[{"text":"(UMI)AAI9211057","href":null,"code":true},{"text":"AAI9211057","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/20625","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Jacobsen, Eric N."]},{"key":"dc:creator","label":"Author","values":["Zhang, Wei"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2011-05-07T12:44:38Z","10000-01-01","1991"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemistry"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Chemistry, Organic"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 1991 Zhang, Wei"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["(UMI)AAI9211057","http://hdl.handle.net/2142/20625","AAI9211057"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Two types of chiral (salen)Mn(III) complexes, either cationic or neutral, were synthesized by complexation of the corresponding chiral salen ligands with manganese salt. Neutral Mn(III) salen complexes were prepared from the ligands and $\\rm Mn(OAc)\\sb2{\\cdot}4H\\sb2O$ via in situ aerial oxidation of the corresponding (salen)Mn(II) species. This approach circumvents the manipulation of highly air sensitive Mn(II) salen intermediates. The use of commercially available bleach solution as the oxidant greatly increases the practical value of this asymmetric epoxidation process.","High enantioselectivities in alkene epoxidation, especially for cis-disubstituted olefins, has been achieved through a rational sequence of ligand modifications. A mechanism involving side-on approach of alkene to a Mn(V)-oxo intermediate accounts for the sense and degree of asymmetric induction with various types of olefins, and it provides a guideline for improving catalyst design.","Electronic environment of the catalyst can dramatically affect the enantioselectivity of olefin epoxidation. Sterically non-biasing substituents were shown in the epoxidation of 2,2-dimethylchromene to effect a difference in $\\Delta\\Delta{\\rm G}{\\sp\\ne}$ of 2.0 Kcal/mol, corresponding to a range in ee's from 22% to 96%. Increases in selectivity due to electron donating substituents are attributed to a more product-like transition structures in the ee-determining olefin oxidation step.","Different reaction mechanisms are proposed for alkyl-substituted and aryl-substituted alkenes. Epoxidation of alkyl-substituted olefins is very likely to be a concerted oxygen transfer process, while a stepwise reaction mechanism is indicated with aryl-substituted olefins.","A convenient and very inexpensive catalyst synthesis, a simple and practical epoxidation procedure, good catalyst turnovers, and high levels of asymmetric induction render the (salen)Mn(III) epoxidation system superior to any other catalytic or stoichiometric asymmetric processes for unfunctionalized olefins reported thus far. Widespread application of these catalysts may be foreseen.","Made available in DSpace on 2011-05-07T12:44:38Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9211057.pdf: 10011689 bytes, checksum: 3b17f6e386c93292d813bfa935dde712 (MD5) Previous issue date: 1991","Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T14:45:09Z Item is restricted indefinitely.","Restriction data tranferred 2014-07-01T11:19:58-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission","ETDs are only available to UIUC Users without author permission","U of I Only"]},{"key":"dc:title","label":"Title","values":["Asymmetric catalytic epoxidations of simple olefins"]}]}],"canonical_facts":{"dc:contributor":["Jacobsen, Eric N."],"dc:creator":["Zhang, Wei"],"dc:date":["2011-05-07T12:44:38Z","10000-01-01","1991"],"dc:description":["Two types of chiral (salen)Mn(III) complexes, either cationic or neutral, were synthesized by complexation of the corresponding chiral salen ligands with manganese salt. Neutral Mn(III) salen complexes were prepared from the ligands and $\\rm Mn(OAc)\\sb2{\\cdot}4H\\sb2O$ via in situ aerial oxidation of the corresponding (salen)Mn(II) species. This approach circumvents the manipulation of highly air sensitive Mn(II) salen intermediates. The use of commercially available bleach solution as the oxidant greatly increases the practical value of this asymmetric epoxidation process.","High enantioselectivities in alkene epoxidation, especially for cis-disubstituted olefins, has been achieved through a rational sequence of ligand modifications. A mechanism involving side-on approach of alkene to a Mn(V)-oxo intermediate accounts for the sense and degree of asymmetric induction with various types of olefins, and it provides a guideline for improving catalyst design.","Electronic environment of the catalyst can dramatically affect the enantioselectivity of olefin epoxidation. Sterically non-biasing substituents were shown in the epoxidation of 2,2-dimethylchromene to effect a difference in $\\Delta\\Delta{\\rm G}{\\sp\\ne}$ of 2.0 Kcal/mol, corresponding to a range in ee's from 22% to 96%. Increases in selectivity due to electron donating substituents are attributed to a more product-like transition structures in the ee-determining olefin oxidation step.","Different reaction mechanisms are proposed for alkyl-substituted and aryl-substituted alkenes. Epoxidation of alkyl-substituted olefins is very likely to be a concerted oxygen transfer process, while a stepwise reaction mechanism is indicated with aryl-substituted olefins.","A convenient and very inexpensive catalyst synthesis, a simple and practical epoxidation procedure, good catalyst turnovers, and high levels of asymmetric induction render the (salen)Mn(III) epoxidation system superior to any other catalytic or stoichiometric asymmetric processes for unfunctionalized olefins reported thus far. Widespread application of these catalysts may be foreseen.","Made available in DSpace on 2011-05-07T12:44:38Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9211057.pdf: 10011689 bytes, checksum: 3b17f6e386c93292d813bfa935dde712 (MD5) Previous issue date: 1991","Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T14:45:09Z Item is restricted indefinitely.","Restriction data tranferred 2014-07-01T11:19:58-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission","ETDs are only available to UIUC Users without author permission","U of I Only"],"dc:identifier":["(UMI)AAI9211057","http://hdl.handle.net/2142/20625","AAI9211057"],"dc:language":["eng"],"dc:rights":["Copyright 1991 Zhang, Wei"],"dc:subject":["Chemistry, Organic"],"dc:title":["Asymmetric catalytic epoxidations of simple olefins"],"dc:type":["text"],"thesis:degree_discipline":["Chemistry"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:25:16Z"}