Chemically bonded stationary phases using molecular tweezer hosts: A quantitative HPLC binding assay for nitro-aromatic guests
Chemically bonded stationary phases (CBSPs) were prepared from the following synthetic hosts: bis-acridine, bis-phenanthrene, and bis-trimethoxyphenanthrene molecular tweezers 74, 89, and 92. The retention times of several $\pi$-electron deficient guests were measured as a function of temperature on HPLC columns made from each of these CBSPs. Van't Hoff plots were generated to give a total of 22 enthalpies of retention which were compared with the corresponding enthalpies of complexation for the analogous host-guest complex in solution. The correlation was found to be within experimental error of a one-to-one correspondence.
Chemistry, Analytical, Chemistry, Organic
University of Illinois - Urbana-Champaign
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University of Illinois at Urbana-Champaign