{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/20317"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/20317","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"The effects of dietary protein source on the development of cholesterol metabolism","abstract":"A large body of literature exists regarding the effects of dietary protein on blood lipids in adult humans and animals; however, little is known of the action that protein source may have on cholesterol levels in infants. The research of this thesis addresses the following questions; (1) do infant formula proteins affect blood lipids in young animals, (2) is there a permanent response of protein consumed during childhood on adult cholesterol metabolism, and (3) what mechanisms mediate the blood lipid response to dietary protein? In a study which examined the effects of varying casein and whey proteins fed to rabbits during post-weaning, it was determined that a diet of 40% casein and 60% whey protein elevated blood lipids compared to consumption of greater proportions of casein (p $<$.05); however, following a cholesterol challenge (0.4%) in adulthood there was no persistent blood lipid response though hepatic cholesterol biosynthesis was elevated in the 40:60-consumers (p $<$.05). Examination of an earlier period in development using the neonatal piglet as a model showed that consumption of increasing proportions of whey protein decreased blood cholesterol concentrations (p $<$.05), and increased weight gain (p $<$.05). 100% casein consumption also decreased hepatic cholesterol biosynthesis (p $<$.05). Furthermore, glucagon and cortisol were possible mediators of the blood and liver responses, as they were also elevated in 100% casein-consumers (p $<$.001). Another experiment fed hydrolyzed soy protein, and casein:whey ratios of 80:20 or 40:60 to neonatal piglets. Soy-fed piglets had significantly lower blood cholesterol levels (p $<$.10), higher HDL:LDL ratios than casein:whey-fed animals (p $<$.10), and decreased body weight (p $<$.10). The association between these findings and a hepatic mechanism could not be clearly defined. In conclusion, blood lipids in young animals are effected by consumption of the infant formula proteins; hydrolyzed soy, casein, and whey. However, the mechanism whereby protein affects cholesterol concentrations remains to be determined. Furthermore, a direct relationship between blood cholesterol levels during childhood and adult risk of atherosclerosis is unclear.","abstract_html":"A large body of literature exists regarding the effects of dietary protein on blood lipids in adult humans and animals; however, little is known of the action that protein source may have on cholesterol levels in infants. The research of this thesis addresses the following questions; (1) do infant formula proteins affect blood lipids in young animals, (2) is there a permanent response of protein consumed during childhood on adult cholesterol metabolism, and (3) what mechanisms mediate the blood lipid response to dietary protein? In a study which examined the effects of varying casein and whey proteins fed to rabbits during post-weaning, it was determined that a diet of 40% casein and 60% whey protein elevated blood lipids compared to consumption of greater proportions of casein (p $&lt;$.05); however, following a cholesterol challenge (0.4%) in adulthood there was no persistent blood lipid response though hepatic cholesterol biosynthesis was elevated in the 40:60-consumers (p $&lt;$.05). Examination of an earlier period in development using the neonatal piglet as a model showed that consumption of increasing proportions of whey protein decreased blood cholesterol concentrations (p $&lt;$.05), and increased weight gain (p $&lt;$.05). 100% casein consumption also decreased hepatic cholesterol biosynthesis (p $&lt;$.05). Furthermore, glucagon and cortisol were possible mediators of the blood and liver responses, as they were also elevated in 100% casein-consumers (p $&lt;$.001). Another experiment fed hydrolyzed soy protein, and casein:whey ratios of 80:20 or 40:60 to neonatal piglets. Soy-fed piglets had significantly lower blood cholesterol levels (p $&lt;$.10), higher HDL:LDL ratios than casein:whey-fed animals (p $&lt;$.10), and decreased body weight (p $&lt;$.10). The association between these findings and a hepatic mechanism could not be clearly defined. In conclusion, blood lipids in young animals are effected by consumption of the infant formula proteins; hydrolyzed soy, casein, and whey. However, the mechanism whereby protein affects cholesterol concentrations remains to be determined. Furthermore, a direct relationship between blood cholesterol levels during childhood and adult risk of atherosclerosis is unclear.","abstract_has_math":true,"creators":["Larson, Mary Rose"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Nutritional Sciences","degree_department":null,"school":null,"contributors":["Erdman, John W."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011-05-07T12:35:47Z","date_published":"2011-05-07T12:35:47Z","updated_at":"2026-07-22T22:25:15Z","subjects":["Chemistry, Biochemistry","Health Sciences, Nutrition"],"languages":["eng"],"rights":["Copyright 1995 Larson, Mary Rose"],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["AAI9543641","(UMI)AAI9543641"],"render_values":[{"text":"AAI9543641","href":null,"code":true},{"text":"(UMI)AAI9543641","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/20317","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Erdman, John W."]},{"key":"dc:creator","label":"Author","values":["Larson, Mary Rose"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2011-05-07T12:35:47Z","10000-01-01","1995"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Nutritional Sciences"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Chemistry, Biochemistry","Health Sciences, Nutrition"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 1995 Larson, Mary Rose"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["AAI9543641","(UMI)AAI9543641","http://hdl.handle.net/2142/20317"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["A large body of literature exists regarding the effects of dietary protein on blood lipids in adult humans and animals; however, little is known of the action that protein source may have on cholesterol levels in infants. The research of this thesis addresses the following questions; (1) do infant formula proteins affect blood lipids in young animals, (2) is there a permanent response of protein consumed during childhood on adult cholesterol metabolism, and (3) what mechanisms mediate the blood lipid response to dietary protein? In a study which examined the effects of varying casein and whey proteins fed to rabbits during post-weaning, it was determined that a diet of 40% casein and 60% whey protein elevated blood lipids compared to consumption of greater proportions of casein (p $<$.05); however, following a cholesterol challenge (0.4%) in adulthood there was no persistent blood lipid response though hepatic cholesterol biosynthesis was elevated in the 40:60-consumers (p $<$.05). Examination of an earlier period in development using the neonatal piglet as a model showed that consumption of increasing proportions of whey protein decreased blood cholesterol concentrations (p $<$.05), and increased weight gain (p $<$.05). 100% casein consumption also decreased hepatic cholesterol biosynthesis (p $<$.05). Furthermore, glucagon and cortisol were possible mediators of the blood and liver responses, as they were also elevated in 100% casein-consumers (p $<$.001). Another experiment fed hydrolyzed soy protein, and casein:whey ratios of 80:20 or 40:60 to neonatal piglets. Soy-fed piglets had significantly lower blood cholesterol levels (p $<$.10), higher HDL:LDL ratios than casein:whey-fed animals (p $<$.10), and decreased body weight (p $<$.10). The association between these findings and a hepatic mechanism could not be clearly defined. In conclusion, blood lipids in young animals are effected by consumption of the infant formula proteins; hydrolyzed soy, casein, and whey. However, the mechanism whereby protein affects cholesterol concentrations remains to be determined. Furthermore, a direct relationship between blood cholesterol levels during childhood and adult risk of atherosclerosis is unclear.","Made available in DSpace on 2011-05-07T12:35:47Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9543641.pdf: 5018370 bytes, checksum: aa199c9b9e3006ff92a9b951067abc4a (MD5) Previous issue date: 1995","Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T14:43:05Z Item is restricted indefinitely.","Restriction data tranferred 2014-07-01T11:18:48-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission","ETDs are only available to UIUC Users without author permission","U of I Only"]},{"key":"dc:title","label":"Title","values":["The effects of dietary protein source on the development of cholesterol metabolism"]}]}],"canonical_facts":{"dc:contributor":["Erdman, John W."],"dc:creator":["Larson, Mary Rose"],"dc:date":["2011-05-07T12:35:47Z","10000-01-01","1995"],"dc:description":["A large body of literature exists regarding the effects of dietary protein on blood lipids in adult humans and animals; however, little is known of the action that protein source may have on cholesterol levels in infants. The research of this thesis addresses the following questions; (1) do infant formula proteins affect blood lipids in young animals, (2) is there a permanent response of protein consumed during childhood on adult cholesterol metabolism, and (3) what mechanisms mediate the blood lipid response to dietary protein? In a study which examined the effects of varying casein and whey proteins fed to rabbits during post-weaning, it was determined that a diet of 40% casein and 60% whey protein elevated blood lipids compared to consumption of greater proportions of casein (p $<$.05); however, following a cholesterol challenge (0.4%) in adulthood there was no persistent blood lipid response though hepatic cholesterol biosynthesis was elevated in the 40:60-consumers (p $<$.05). Examination of an earlier period in development using the neonatal piglet as a model showed that consumption of increasing proportions of whey protein decreased blood cholesterol concentrations (p $<$.05), and increased weight gain (p $<$.05). 100% casein consumption also decreased hepatic cholesterol biosynthesis (p $<$.05). Furthermore, glucagon and cortisol were possible mediators of the blood and liver responses, as they were also elevated in 100% casein-consumers (p $<$.001). Another experiment fed hydrolyzed soy protein, and casein:whey ratios of 80:20 or 40:60 to neonatal piglets. Soy-fed piglets had significantly lower blood cholesterol levels (p $<$.10), higher HDL:LDL ratios than casein:whey-fed animals (p $<$.10), and decreased body weight (p $<$.10). The association between these findings and a hepatic mechanism could not be clearly defined. In conclusion, blood lipids in young animals are effected by consumption of the infant formula proteins; hydrolyzed soy, casein, and whey. However, the mechanism whereby protein affects cholesterol concentrations remains to be determined. Furthermore, a direct relationship between blood cholesterol levels during childhood and adult risk of atherosclerosis is unclear.","Made available in DSpace on 2011-05-07T12:35:47Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9543641.pdf: 5018370 bytes, checksum: aa199c9b9e3006ff92a9b951067abc4a (MD5) Previous issue date: 1995","Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T14:43:05Z Item is restricted indefinitely.","Restriction data tranferred 2014-07-01T11:18:48-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission","ETDs are only available to UIUC Users without author permission","U of I Only"],"dc:identifier":["AAI9543641","(UMI)AAI9543641","http://hdl.handle.net/2142/20317"],"dc:language":["eng"],"dc:rights":["Copyright 1995 Larson, Mary Rose"],"dc:subject":["Chemistry, Biochemistry","Health Sciences, Nutrition"],"dc:title":["The effects of dietary protein source on the development of cholesterol metabolism"],"dc:type":["text"],"thesis:degree_discipline":["Nutritional Sciences"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:25:15Z"}