The potential role of interleukin-2 in impaired cell-mediated immunity of iron deficiency
Iron deficiency impairs cell-mediated immunity, which is primarily dependent on T-lymphocyte functions including production of the cytokine, interleukin 2 (IL-2). The potential role of IL-2 production and responsiveness in impaired cell-mediated immunity of iron deficiency was investigated in a series of experiments. Immune parameters were measured in unstimulated and concanavalin A (Con A)-stimulated spleen lymphocytes from rats and mice. Dietary iron deficiency induced in the weanling Sprague-Dawley rat and C57/B16 mouse were used as the nutritional models.
Biology, Cell, Biology, Microbiology, Health Sciences, Nutrition
University of Illinois - Urbana-Champaign
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University of Illinois at Urbana-Champaign