{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/20192"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/20192","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Cytokines in neuroimmunomodulation and neuropathology: Dual expression of the p80 type I and p68 type II interleukin-1 receptors on murine growth hormone producing cells. Murine neurovirulent retrovirus ts-1-MoMulV induces tumor necrosis factor-alpha and nitric oxide secretion from glial cultures in vitro","abstract":"Restriction data tranferred 2014-07-01T11:18:20-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission","abstract_html":"Restriction data tranferred 2014-07-01T11:18:20-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission","abstract_has_math":false,"creators":["French, Richard Alan"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Pathobiology","degree_department":null,"school":null,"contributors":["Zachary, James F."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011-05-07T12:31:47Z","date_published":"2011-05-07T12:31:47Z","updated_at":"2026-07-22T22:25:15Z","subjects":["Biology, Neuroscience","Biology, Cell","Health Sciences, Pathology","Biology, Veterinary Science","Health Sciences, Immunology"],"languages":["eng"],"rights":["Copyright 1996 French, Richard Alan"],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["9780591087901","AAI9702518","(UMI)AAI9702518"],"render_values":[{"text":"9780591087901","href":null,"code":true},{"text":"AAI9702518","href":null,"code":true},{"text":"(UMI)AAI9702518","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/20192","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Zachary, James F."]},{"key":"dc:creator","label":"Author","values":["French, Richard Alan"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2011-05-07T12:31:47Z","10000-01-01","1996"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Pathobiology"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Biology, Neuroscience","Biology, Cell","Health Sciences, Pathology","Biology, Veterinary Science","Health Sciences, Immunology"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 1996 French, Richard Alan"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["9780591087901","AAI9702518","(UMI)AAI9702518","http://hdl.handle.net/2142/20192"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Restriction data tranferred 2014-07-01T11:18:20-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission","Inflammatory cytokines, interleukin 1 (IL-1$\\alpha,$ IL-1$\\beta$) and tumor necrosis factor (TNF-$\\alpha),$ are coordinators of the immune and inflammatory responses but also play a critical regulatory role in brain development, function, disease and regulation of the neuroendocrine immune axis. In the latter context, inflammatory cytokines modulate the synthesis and secretion of various pituitary hormones including growth hormone (GH) and adrenocorticotropic hormone (ACTH). IL-1$\\alpha$ and IL-1$\\beta$ exert their effects by interaction with two distinct receptors, p80 IL-1R and p68 IL-1R. We have used immunohistochemistry to demonstrate the cellular localization and dual expression of the IL-1R isoforms in the murine adenohypophysis. In conjunction with previous studies demonstrating high affinity binding sites for IL-1$\\alpha,$ expression of the p80 and p68 IL-1R mRNA, and the identification of the p80 IL-1R protein in the adenohypophysis, we have shown that expression of the p80 and p68 IL-1R proteins is restricted to predominantly those cells that synthesize GH, and that there is expression of both IL-1R isoforms on the same cell population. These findings corroborate the role of GH in the neuroendocrine immune axis and suggest that IL-1 mediated GH release is regulated, in part, at the level of the pituitary and is finely regulated.","\"Neurovirulent ts1 MoMuLV is an animal model for motor neuron and neurodegenerative diseases such as amyotrophic lateral sclerosis and AIDS dementia complex (ADC). Our studies have identified a potential indirect mechanism for neuronal degeneration similar to the proposed neuropathogenesis of ADC. Resident CNS microglial cells are the principal cell target for ts1 MoMuLV infection and neurons are \"\"innocent\"\" bystander cells indirectly affected by activation of the microglial cells. Results indicate that induction of TNF-$\\alpha$ (bioassay, WEHI 164 cells, $217\\pm15$ pg TNF-$\\alpha$/ml/10$\\sp5$ microglial cells; ELISA $577\\pm100$ pg TNF-$\\alpha$ml/10$\\sp5$ microglial cells), and nitric oxide (NO) are associated with glial cell infection by ts1 MoMuLV. The findings suggest that ts1 MoMuLV neurotoxicity in the murine retroviral neuroimmunodegenerative disease may be associated with the induction of TNF-$\\alpha$ and/or NO.\"","Made available in DSpace on 2011-05-07T12:31:47Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9702518.pdf: 8707573 bytes, checksum: d11707c3fb7e47549721bc89fa31cc95 (MD5) Previous issue date: 1996","Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T14:42:14Z Item is restricted indefinitely.","ETDs are only available to UIUC Users without author permission","U of I Only"]},{"key":"dc:title","label":"Title","values":["Cytokines in neuroimmunomodulation and neuropathology: Dual expression of the p80 type I and p68 type II interleukin-1 receptors on murine growth hormone producing cells. Murine neurovirulent retrovirus ts-1-MoMulV induces tumor necrosis factor-alpha and nitric oxide secretion from glial cultures in vitro"]}]}],"canonical_facts":{"dc:contributor":["Zachary, James F."],"dc:creator":["French, Richard Alan"],"dc:date":["2011-05-07T12:31:47Z","10000-01-01","1996"],"dc:description":["Restriction data tranferred 2014-07-01T11:18:20-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission","Inflammatory cytokines, interleukin 1 (IL-1$\\alpha,$ IL-1$\\beta$) and tumor necrosis factor (TNF-$\\alpha),$ are coordinators of the immune and inflammatory responses but also play a critical regulatory role in brain development, function, disease and regulation of the neuroendocrine immune axis. In the latter context, inflammatory cytokines modulate the synthesis and secretion of various pituitary hormones including growth hormone (GH) and adrenocorticotropic hormone (ACTH). IL-1$\\alpha$ and IL-1$\\beta$ exert their effects by interaction with two distinct receptors, p80 IL-1R and p68 IL-1R. We have used immunohistochemistry to demonstrate the cellular localization and dual expression of the IL-1R isoforms in the murine adenohypophysis. In conjunction with previous studies demonstrating high affinity binding sites for IL-1$\\alpha,$ expression of the p80 and p68 IL-1R mRNA, and the identification of the p80 IL-1R protein in the adenohypophysis, we have shown that expression of the p80 and p68 IL-1R proteins is restricted to predominantly those cells that synthesize GH, and that there is expression of both IL-1R isoforms on the same cell population. These findings corroborate the role of GH in the neuroendocrine immune axis and suggest that IL-1 mediated GH release is regulated, in part, at the level of the pituitary and is finely regulated.","\"Neurovirulent ts1 MoMuLV is an animal model for motor neuron and neurodegenerative diseases such as amyotrophic lateral sclerosis and AIDS dementia complex (ADC). Our studies have identified a potential indirect mechanism for neuronal degeneration similar to the proposed neuropathogenesis of ADC. Resident CNS microglial cells are the principal cell target for ts1 MoMuLV infection and neurons are \"\"innocent\"\" bystander cells indirectly affected by activation of the microglial cells. Results indicate that induction of TNF-$\\alpha$ (bioassay, WEHI 164 cells, $217\\pm15$ pg TNF-$\\alpha$/ml/10$\\sp5$ microglial cells; ELISA $577\\pm100$ pg TNF-$\\alpha$ml/10$\\sp5$ microglial cells), and nitric oxide (NO) are associated with glial cell infection by ts1 MoMuLV. The findings suggest that ts1 MoMuLV neurotoxicity in the murine retroviral neuroimmunodegenerative disease may be associated with the induction of TNF-$\\alpha$ and/or NO.\"","Made available in DSpace on 2011-05-07T12:31:47Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9702518.pdf: 8707573 bytes, checksum: d11707c3fb7e47549721bc89fa31cc95 (MD5) Previous issue date: 1996","Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T14:42:14Z Item is restricted indefinitely.","ETDs are only available to UIUC Users without author permission","U of I Only"],"dc:identifier":["9780591087901","AAI9702518","(UMI)AAI9702518","http://hdl.handle.net/2142/20192"],"dc:language":["eng"],"dc:rights":["Copyright 1996 French, Richard Alan"],"dc:subject":["Biology, Neuroscience","Biology, Cell","Health Sciences, Pathology","Biology, Veterinary Science","Health Sciences, Immunology"],"dc:title":["Cytokines in neuroimmunomodulation and neuropathology: Dual expression of the p80 type I and p68 type II interleukin-1 receptors on murine growth hormone producing cells. Murine neurovirulent retrovirus ts-1-MoMulV induces tumor necrosis factor-alpha and nitric oxide secretion from glial cultures in vitro"],"dc:type":["text"],"thesis:degree_discipline":["Pathobiology"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:25:15Z"}