Comparison of polychlorinated biphenyl profiles in rat, fish and human tissues; the effects of consuming Great Lakes fish
type: CreativeWork
description: The food chain transfer of Polychlorinated Biphenyl (PCB) congeners was assessed in rat and human tissue after the consumption of contaminated Great Lakes fish. Fish from Lake Superior (LS), Lake Michigan (LM), and Lake Huron (LH) were examined for either total PCB or specific congener concentrations. Total PCBs were highest in carp, lake trout and siscowet lake trout compared to walleye, whitefish, and Pacific salmon. The profiles of individual congeners differed between the species, with whitefish containing tri- and tetrachlorobiphenyl congeners in the highest concentrations and lake trout and siscowet lake trout containing hexa- and heptachlorobiphenyls. Congeners 28, 47/48, 52, 66/95, 77/110, 118, 138, and 153 were found in most species. Lake, species, and the lake$\sp*$species interaction were determined to be the best predictors of PCB concentrations in fish using a MANOVA statistical model. Three studies were completed which fed adult male rodents fish as 30% of the total diet for 45 days, adult females for 90 days, and timed pregnant females throughout gestation and lactation. PCB congeners were transferred from the fish diets and were found in blood and brain tissue from the rats. PCB congeners found in brain tissue contained ortho substitutions, these included 28, 47/48, 49, 52, 118, 153 from all three rodent studies. Differences in PCB congeners were seen after 45 and 90 day exposure to the same diets, these differences are most likely due to an increased enzyme activity after the longer period of exposure, or alternatively may be due to differences between the sexes. No statistically significant differences regarding the accumulation of individual congeners in male and female pups from the developmental exposure could be determined. Human serum samples and epidemiologic information was collected from Native Americans residing on seven Great Lakes based reservations. The participants consumed lake trout, whitefish and walleye most frequently, and accumul…
abstract: The food chain transfer of Polychlorinated Biphenyl (PCB) congeners was assessed in rat and human tissue after the consumption of contaminated Great Lakes fish. Fish from Lake Superior (LS), Lake Michigan (LM), and Lake Huron (LH) were examined for either total PCB or specific congener concentrations. Total PCBs were highest in carp, lake trout and siscowet lake trout compared to walleye, whitefish, and Pacific salmon. The profiles of individual congeners differed between the species, with whitefish containing tri- and tetrachlorobiphenyl congeners in the highest concentrations and lake trout and siscowet lake trout containing hexa- and heptachlorobiphenyls. Congeners 28, 47/48, 52, 66/95, 77/110, 118, 138, and 153 were found in most species. Lake, species, and the lake$\sp*$species interaction were determined to be the best predictors of PCB concentrations in fish using a MANOVA statistical model. Three studies were completed which fed adult male rodents fish as 30% of the total diet for 45 days, adult females for 90 days, and timed pregnant females throughout gestation and lactation. PCB congeners were transferred from the fish diets and were found in blood and brain tissue from the rats. PCB congeners found in brain tissue contained ortho substitutions, these included 28, 47/48, 49, 52, 118, 153 from all three rodent studies. Differences in PCB congeners were seen after 45 and 90 day exposure to the same diets, these differences are most likely due to an increased enzyme activity after the longer period of exposure, or alternatively may be due to differences between the sexes. No statistically significant differences regarding the accumulation of individual congeners in male and female pups from the developmental exposure could be determined. Human serum samples and epidemiologic information was collected from Native Americans residing on seven Great Lakes based reservations. The participants consumed lake trout, whitefish and walleye most frequently, and accumul…
author: Gerstenberger, Shawn Loren
language: eng
keywords: Health Sciences, Toxicology, Environmental Sciences
date published: 2011-05-07T12:23:39Z
date modified: 2026-07-22T22:25:15Z
provider: University of Illinois - Urbana-Champaign
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: University of Illinois at Urbana-Champaign

PropertyValue
property ID: Handle
value: http://hdl.handle.net/2142/19942