{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/19889"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/19889","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"The toxicity of microcystin-LR in swine and mice","abstract":"Microcystin-LR (MCLR) is a monocyclic heptapeptide hepatotoxin produced by the cyanobacterium Microcystis aeruginosa. One gilt given whole M. aeruginosa cells ig containing 0.3% MCLR and des-methyl MCLR at 2.1 g/kg had severe panlobular hepatic necrosis and hemorrhage when euthanatized at 32.5 hr postdosing.","abstract_html":"Microcystin-LR (MCLR) is a monocyclic heptapeptide hepatotoxin produced by the cyanobacterium Microcystis aeruginosa. One gilt given whole M. aeruginosa cells ig containing 0.3% MCLR and des-methyl MCLR at 2.1 g/kg had severe panlobular hepatic necrosis and hemorrhage when euthanatized at 32.5 hr postdosing.","abstract_has_math":false,"creators":["Lovell, Randall Anderson"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Veterinary Biosciences","degree_department":null,"school":null,"contributors":["Beasley, Val Richard"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011-05-07T12:21:55Z","date_published":"2011-05-07T12:21:55Z","updated_at":"2026-07-22T22:25:14Z","subjects":["Biology, Animal Physiology","Health Sciences, Pathology","Biology, Veterinary Science"],"languages":["eng"],"rights":["Copyright 1989 Lovell, Randall Anderson"],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["AAI9010942","(UMI)AAI9010942"],"render_values":[{"text":"AAI9010942","href":null,"code":true},{"text":"(UMI)AAI9010942","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/19889","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Beasley, Val Richard"]},{"key":"dc:creator","label":"Author","values":["Lovell, Randall Anderson"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2011-05-07T12:21:55Z","10000-01-01","1989"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Veterinary Biosciences"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Biology, Animal Physiology","Health Sciences, Pathology","Biology, Veterinary Science"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 1989 Lovell, Randall Anderson"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["AAI9010942","(UMI)AAI9010942","http://hdl.handle.net/2142/19889"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Microcystin-LR (MCLR) is a monocyclic heptapeptide hepatotoxin produced by the cyanobacterium Microcystis aeruginosa. One gilt given whole M. aeruginosa cells ig containing 0.3% MCLR and des-methyl MCLR at 2.1 g/kg had severe panlobular hepatic necrosis and hemorrhage when euthanatized at 32.5 hr postdosing.","Mean liver and kidney weights increased 50-64% and 20-32%, respectively, in two strains of male mice that died within 200 minutes after a single lethal ip dose of purified MCLR. Mice that survived an ip LD$\\sb{23}$ or LD$\\sb{30}$ of MCLR had significantly longer survival times and higher survival rates when given an approximate ip LD$\\sb{100}$ minimum (40-75 $\\mu$g/kg) 2 or 3 days later.","The liver (34.01 IU/g), pancreas (5.43 IU/g), and kidney (3.24 IU/g) were the only swine tissues with mean arginase activity (ARG) greater than 0.52 IU/g. The serum t${1\\over2}$ of ARG in a barrow and gilt were 85.8 and 128.0 minutes (min).","Between 12 and 24 min after anesthetized gilts were given a lethal iv dose of purified MCLR (72 $\\mu$g/kg), mean aortic and central venous pressures, and renal and hepatic perfusion decreased ($\\downarrow$) significantly, while portal venous pressure increased ($\\uparrow$) significantly. Significant changes at 45 min included $\\uparrow$ bile acids, total bilirubin, lactate, K, and pO$\\sb2$, and $\\downarrow$ platelet count, base excess, Hct, HCO$\\sb3-$, and pCO$\\sb2$. At 90 min, significant changes included $\\uparrow$ ARG, P, BUN, and creatinine, and $\\downarrow$ pH and glucose. Significant changes 150 min postdosing included $\\uparrow$ AST, AP, ALT, CPK, and LDH. Livers were markedly enlarged, dark purple-red in color, and readily exuded blood on cut surfaces. Significantly $\\uparrow$ liver weights and liver Fe and Hb concentrations were suggestive that 37.9% of the estimated blood volume was present in the liver. The major cause of acute death ($<$5 hr) following iv MCLR dosing in swine is hypovolemic shock which results from massive intrahepatic hemorrhage.","Made available in DSpace on 2011-05-07T12:21:55Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9010942.pdf: 9195790 bytes, checksum: f70b45b44c56c28261445a5da040314c (MD5) Previous issue date: 1989","Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T14:40:07Z Item is restricted indefinitely.","Restriction data tranferred 2014-07-01T11:17:06-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission","ETDs are only available to UIUC Users without author permission","U of I Only"]},{"key":"dc:title","label":"Title","values":["The toxicity of microcystin-LR in swine and mice"]}]}],"canonical_facts":{"dc:contributor":["Beasley, Val Richard"],"dc:creator":["Lovell, Randall Anderson"],"dc:date":["2011-05-07T12:21:55Z","10000-01-01","1989"],"dc:description":["Microcystin-LR (MCLR) is a monocyclic heptapeptide hepatotoxin produced by the cyanobacterium Microcystis aeruginosa. One gilt given whole M. aeruginosa cells ig containing 0.3% MCLR and des-methyl MCLR at 2.1 g/kg had severe panlobular hepatic necrosis and hemorrhage when euthanatized at 32.5 hr postdosing.","Mean liver and kidney weights increased 50-64% and 20-32%, respectively, in two strains of male mice that died within 200 minutes after a single lethal ip dose of purified MCLR. Mice that survived an ip LD$\\sb{23}$ or LD$\\sb{30}$ of MCLR had significantly longer survival times and higher survival rates when given an approximate ip LD$\\sb{100}$ minimum (40-75 $\\mu$g/kg) 2 or 3 days later.","The liver (34.01 IU/g), pancreas (5.43 IU/g), and kidney (3.24 IU/g) were the only swine tissues with mean arginase activity (ARG) greater than 0.52 IU/g. The serum t${1\\over2}$ of ARG in a barrow and gilt were 85.8 and 128.0 minutes (min).","Between 12 and 24 min after anesthetized gilts were given a lethal iv dose of purified MCLR (72 $\\mu$g/kg), mean aortic and central venous pressures, and renal and hepatic perfusion decreased ($\\downarrow$) significantly, while portal venous pressure increased ($\\uparrow$) significantly. Significant changes at 45 min included $\\uparrow$ bile acids, total bilirubin, lactate, K, and pO$\\sb2$, and $\\downarrow$ platelet count, base excess, Hct, HCO$\\sb3-$, and pCO$\\sb2$. At 90 min, significant changes included $\\uparrow$ ARG, P, BUN, and creatinine, and $\\downarrow$ pH and glucose. Significant changes 150 min postdosing included $\\uparrow$ AST, AP, ALT, CPK, and LDH. Livers were markedly enlarged, dark purple-red in color, and readily exuded blood on cut surfaces. Significantly $\\uparrow$ liver weights and liver Fe and Hb concentrations were suggestive that 37.9% of the estimated blood volume was present in the liver. The major cause of acute death ($<$5 hr) following iv MCLR dosing in swine is hypovolemic shock which results from massive intrahepatic hemorrhage.","Made available in DSpace on 2011-05-07T12:21:55Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9010942.pdf: 9195790 bytes, checksum: f70b45b44c56c28261445a5da040314c (MD5) Previous issue date: 1989","Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T14:40:07Z Item is restricted indefinitely.","Restriction data tranferred 2014-07-01T11:17:06-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission","ETDs are only available to UIUC Users without author permission","U of I Only"],"dc:identifier":["AAI9010942","(UMI)AAI9010942","http://hdl.handle.net/2142/19889"],"dc:language":["eng"],"dc:rights":["Copyright 1989 Lovell, Randall Anderson"],"dc:subject":["Biology, Animal Physiology","Health Sciences, Pathology","Biology, Veterinary Science"],"dc:title":["The toxicity of microcystin-LR in swine and mice"],"dc:type":["text"],"thesis:degree_discipline":["Veterinary Biosciences"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:25:14Z"}