Biologically active compounds from tunicates and a sponge
type: CreativeWork
description: Part I. Studies on structures and biological activities of didemnins. Six new cyclic depsipeptides related to didemnins were isolated from a relatively polar extract of the tunicate T. solidum. Their structures were determined by spectroscopic techniques and chemical degradations as follows: didemnins X ((R)-3-hydroxydecanoyl-(Gln)$\sb3$-Lac-Pro-didemnin A); Y ((R)-3-hydroxydecanoyl-(Gln)$\sb4$-Lac-Pro-didemnin A); M (pGlu-Gln-Lac-Pro-didemnin A); N ( (Tyr$\sp5$) didemnin B); nordidemnin N ( (Tyr$\sp5$) nordidemnin B); and epididemnin A ( ($2S,4R$-Hip$\sp2$) didemnin A). Twenty two new didemnin analogues were prepared semisynthetically. Structure elucidation, chemical conversion, biological activities including cytotoxicity, antiviral and immunosuppressive activities and structure-activity relationships for the above compounds are described.
abstract: Part I. Studies on structures and biological activities of didemnins. Six new cyclic depsipeptides related to didemnins were isolated from a relatively polar extract of the tunicate T. solidum. Their structures were determined by spectroscopic techniques and chemical degradations as follows: didemnins X ((R)-3-hydroxydecanoyl-(Gln)$\sb3$-Lac-Pro-didemnin A); Y ((R)-3-hydroxydecanoyl-(Gln)$\sb4$-Lac-Pro-didemnin A); M (pGlu-Gln-Lac-Pro-didemnin A); N ( (Tyr$\sp5$) didemnin B); nordidemnin N ( (Tyr$\sp5$) nordidemnin B); and epididemnin A ( ($2S,4R$-Hip$\sp2$) didemnin A). Twenty two new didemnin analogues were prepared semisynthetically. Structure elucidation, chemical conversion, biological activities including cytotoxicity, antiviral and immunosuppressive activities and structure-activity relationships for the above compounds are described.
author: Sakai, Ryuichi
language: eng
keywords: Chemistry, Organic, Chemistry, Pharmaceutical
date published: 2011-05-07T12:15:50Z
date modified: 2026-07-22T22:25:14Z
provider: University of Illinois - Urbana-Champaign
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: University of Illinois at Urbana-Champaign

PropertyValue
property ID: Handle
value: http://hdl.handle.net/2142/19702