{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/19586"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/19586","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Bovine acute mastitis: Effect of sodium salicylate on inflammation","abstract":"Experiment 1, 8 cows, was designed to evaluate the effect of sodium salicylate on acute inflammatory responses by means of milk indicators of mastitis, somatic cell count and milk serum albumin, an inflammatory mediator (prostaglandin F$\\sb{2\\alpha}$), quarter milk yield, and clinical responses, gross udder inflammation, body temperature and appetite change.","abstract_html":"Experiment 1, 8 cows, was designed to evaluate the effect of sodium salicylate on acute inflammatory responses by means of milk indicators of mastitis, somatic cell count and milk serum albumin, an inflammatory mediator (prostaglandin F<span class=\"etd-inline-math\">\\sb{2&alpha;}</span>), quarter milk yield, and clinical responses, gross udder inflammation, body temperature and appetite change.","abstract_has_math":true,"creators":["Morkoc, Amy Carol"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Animal Science","degree_department":null,"school":null,"contributors":["Spahr, Sidney L."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011-05-07T12:12:15Z","date_published":"2011-05-07T12:12:15Z","updated_at":"2026-07-22T22:25:14Z","subjects":["Health Sciences, Pharmacology","Biology, Veterinary Science","Health Sciences, Immunology"],"languages":["eng"],"rights":["Copyright 1991 Morkoc, Amy Carol"],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["AAI9124464","(UMI)AAI9124464"],"render_values":[{"text":"AAI9124464","href":null,"code":true},{"text":"(UMI)AAI9124464","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/19586","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Spahr, Sidney L."]},{"key":"dc:creator","label":"Author","values":["Morkoc, Amy Carol"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2011-05-07T12:12:15Z","10000-01-01","1991"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Animal Science"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Health Sciences, Pharmacology","Biology, Veterinary Science","Health Sciences, Immunology"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 1991 Morkoc, Amy Carol"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["AAI9124464","(UMI)AAI9124464","http://hdl.handle.net/2142/19586"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Experiment 1, 8 cows, was designed to evaluate the effect of sodium salicylate on acute inflammatory responses by means of milk indicators of mastitis, somatic cell count and milk serum albumin, an inflammatory mediator (prostaglandin F$\\sb{2\\alpha}$), quarter milk yield, and clinical responses, gross udder inflammation, body temperature and appetite change.","Experiment 2, 10 cows, was designed to evaluate the long term effect of sodium salicylate on inflammation and milk yield. Milk indicators of mastitis, inflammatory mediator in blood, milk yield and clinical responses were evaluated.","Cows treated with sodium salicylate (treatment group) exhibited a change in character of inflammation. Not all changes were considered beneficial. In acute inflammation, Experiment 1, somatic cell count and milk serum albumin were reduced in sodium salicylate-treated cows but only BSA significantly. The inflammatory mediator in blood and lymph, prostaglandin F$\\sb{2\\alpha}$, was reduced after endotoxin in treatment and control cows, with a significantly lower drop in plasma from cows treated with sodium salicylate. Milk yield was reduced in all quarters, with a greater decrease in sodium salicylate-treated cows, except in the endotoxin-infused quarter. Clinically, the sodium salicylate-treated cows had a minimal increase of body temperature compared to a dramatic increase in control cows. Appetite decline was not significantly different between groups. There was not a significant effect of sodium salicylate on gross inflammation of the udder. Evaluation of data representing PGF$\\sb{2\\alpha}$ in lymph which demonstrated increased metabolite levels, indicated that production of the inflammatory mediator was local within the mammary gland, in comparison to venous plasma, wherein the increase of PGF$\\sb{2\\alpha}$ did not appear.","In the longer term study (Experiment 2), with samples at longer intervals, results were similar to Experiment 1. With this experimental design, differences in somatic cell count and milk serum albumin were not found. The inflammatory mediator (PGF$\\sb{2\\alpha}$) measured in jugular plasma was significantly lower in sodium salicylate-treated cows than in controls, but both groups had decreased levels after endotoxin infusion. Gross inflammation was not different between treatment groups. Milk yield declined to a lower level in treated cows. (Abstract shortened with permission of author.)","Made available in DSpace on 2011-05-07T12:12:15Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9124464.pdf: 6240357 bytes, checksum: 4abd43acaa322f9451982dffcea648c6 (MD5) Previous issue date: 1991","Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T14:38:03Z Item is restricted indefinitely.","Restriction data tranferred 2014-07-01T11:15:46-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission","ETDs are only available to UIUC Users without author permission","U of I Only"]},{"key":"dc:title","label":"Title","values":["Bovine acute mastitis: Effect of sodium salicylate on inflammation"]}]}],"canonical_facts":{"dc:contributor":["Spahr, Sidney L."],"dc:creator":["Morkoc, Amy Carol"],"dc:date":["2011-05-07T12:12:15Z","10000-01-01","1991"],"dc:description":["Experiment 1, 8 cows, was designed to evaluate the effect of sodium salicylate on acute inflammatory responses by means of milk indicators of mastitis, somatic cell count and milk serum albumin, an inflammatory mediator (prostaglandin F$\\sb{2\\alpha}$), quarter milk yield, and clinical responses, gross udder inflammation, body temperature and appetite change.","Experiment 2, 10 cows, was designed to evaluate the long term effect of sodium salicylate on inflammation and milk yield. Milk indicators of mastitis, inflammatory mediator in blood, milk yield and clinical responses were evaluated.","Cows treated with sodium salicylate (treatment group) exhibited a change in character of inflammation. Not all changes were considered beneficial. In acute inflammation, Experiment 1, somatic cell count and milk serum albumin were reduced in sodium salicylate-treated cows but only BSA significantly. The inflammatory mediator in blood and lymph, prostaglandin F$\\sb{2\\alpha}$, was reduced after endotoxin in treatment and control cows, with a significantly lower drop in plasma from cows treated with sodium salicylate. Milk yield was reduced in all quarters, with a greater decrease in sodium salicylate-treated cows, except in the endotoxin-infused quarter. Clinically, the sodium salicylate-treated cows had a minimal increase of body temperature compared to a dramatic increase in control cows. Appetite decline was not significantly different between groups. There was not a significant effect of sodium salicylate on gross inflammation of the udder. Evaluation of data representing PGF$\\sb{2\\alpha}$ in lymph which demonstrated increased metabolite levels, indicated that production of the inflammatory mediator was local within the mammary gland, in comparison to venous plasma, wherein the increase of PGF$\\sb{2\\alpha}$ did not appear.","In the longer term study (Experiment 2), with samples at longer intervals, results were similar to Experiment 1. With this experimental design, differences in somatic cell count and milk serum albumin were not found. The inflammatory mediator (PGF$\\sb{2\\alpha}$) measured in jugular plasma was significantly lower in sodium salicylate-treated cows than in controls, but both groups had decreased levels after endotoxin infusion. Gross inflammation was not different between treatment groups. Milk yield declined to a lower level in treated cows. (Abstract shortened with permission of author.)","Made available in DSpace on 2011-05-07T12:12:15Z (GMT). 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