{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/18820"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/18820","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"The effects of alterations in internal Ca levels on cat small intestinal slow waves","abstract":"Control of slow wave frequency in cat small intestinal muscle was investigated with microelectrodes. Exposure of intact muscle or isolated longitudinal muscle to low Ca('2+) saline decreased slow wave frequency with less than a 6 mV change in resting potential. This frequency decline was characterized by a prolongation of the diastolic phase of the slow wave. Raising Ca(,0)('2+) to 2-3 times normal increased slow wave frequency. At Ca(,0)('2+) greater than 4 times normal, the slow wave frequency again decreased. However, this decrease in frequency was characterized by a prolongation of the systolic phase of the waveform. Application of Ca conductance blockers (Co('2+), Mn('2+), D600, verapamil), increasing Mg(,0)('2+) or increasing internal pH decreased slow wave frequency by a prolongation of the diastolic region of the slow wave. Addition of db-cAMP to Krebs saline made hypertonic with sucrose or decreasing internal pH increased slow wave frequency. These results indicate a relationship between internal Ca('2+) and the pacemaker of slow wave frequency. A scheme is proposed to explain that relationship.","abstract_html":"Control of slow wave frequency in cat small intestinal muscle was investigated with microelectrodes. Exposure of intact muscle or isolated longitudinal muscle to low Ca('2+) saline decreased slow wave frequency with less than a 6 mV change in resting potential. This frequency decline was characterized by a prolongation of the diastolic phase of the slow wave. Raising Ca(,0)('2+) to 2-3 times normal increased slow wave frequency. At Ca(,0)('2+) greater than 4 times normal, the slow wave frequency again decreased. However, this decrease in frequency was characterized by a prolongation of the systolic phase of the waveform. Application of Ca conductance blockers (Co('2+), Mn('2+), D600, verapamil), increasing Mg(,0)('2+) or increasing internal pH decreased slow wave frequency by a prolongation of the diastolic region of the slow wave. Addition of db-cAMP to Krebs saline made hypertonic with sucrose or decreasing internal pH increased slow wave frequency. These results indicate a relationship between internal Ca('2+) and the pacemaker of slow wave frequency. A scheme is proposed to explain that relationship.","abstract_has_math":false,"creators":["Mangel, Allen W."],"institution":null,"degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Physiology","degree_department":null,"school":null,"contributors":["Prosser, C. 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Exposure of intact muscle or isolated longitudinal muscle to low Ca('2+) saline decreased slow wave frequency with less than a 6 mV change in resting potential. This frequency decline was characterized by a prolongation of the diastolic phase of the slow wave. Raising Ca(,0)('2+) to 2-3 times normal increased slow wave frequency. At Ca(,0)('2+) greater than 4 times normal, the slow wave frequency again decreased. However, this decrease in frequency was characterized by a prolongation of the systolic phase of the waveform. Application of Ca conductance blockers (Co('2+), Mn('2+), D600, verapamil), increasing Mg(,0)('2+) or increasing internal pH decreased slow wave frequency by a prolongation of the diastolic region of the slow wave. Addition of db-cAMP to Krebs saline made hypertonic with sucrose or decreasing internal pH increased slow wave frequency. These results indicate a relationship between internal Ca('2+) and the pacemaker of slow wave frequency. A scheme is proposed to explain that relationship.","Submitted by Sarah Shreeves (sshreeve@illinois.edu) on 2011-04-13T17:37:41Z No. of bitstreams: 1 Mangel_Allen.pdf: 14571941 bytes, checksum: 0f3f5efb85f424eeea5b106d6fb97b18 (MD5)","Made available in DSpace on 2011-04-13T17:37:41Z (GMT). No. of bitstreams: 1 Mangel_Allen.pdf: 14571941 bytes, checksum: 0f3f5efb85f424eeea5b106d6fb97b18 (MD5) Previous issue date: 1980"]},{"key":"dc:title","label":"Title","values":["The effects of alterations in internal Ca levels on cat small intestinal slow waves"]}]}],"canonical_facts":{"dc:contributor":["Prosser, C. Ladd","Curtis, Brian A.","Connor, John A.","Arntzen, Charles J.","Sherwood, O. David"],"dc:creator":["Mangel, Allen W."],"dc:date":["2011-04-13T17:37:41Z","1980"],"dc:description":["Control of slow wave frequency in cat small intestinal muscle was investigated with microelectrodes. Exposure of intact muscle or isolated longitudinal muscle to low Ca('2+) saline decreased slow wave frequency with less than a 6 mV change in resting potential. This frequency decline was characterized by a prolongation of the diastolic phase of the slow wave. Raising Ca(,0)('2+) to 2-3 times normal increased slow wave frequency. At Ca(,0)('2+) greater than 4 times normal, the slow wave frequency again decreased. However, this decrease in frequency was characterized by a prolongation of the systolic phase of the waveform. Application of Ca conductance blockers (Co('2+), Mn('2+), D600, verapamil), increasing Mg(,0)('2+) or increasing internal pH decreased slow wave frequency by a prolongation of the diastolic region of the slow wave. Addition of db-cAMP to Krebs saline made hypertonic with sucrose or decreasing internal pH increased slow wave frequency. These results indicate a relationship between internal Ca('2+) and the pacemaker of slow wave frequency. A scheme is proposed to explain that relationship.","Submitted by Sarah Shreeves (sshreeve@illinois.edu) on 2011-04-13T17:37:41Z No. of bitstreams: 1 Mangel_Allen.pdf: 14571941 bytes, checksum: 0f3f5efb85f424eeea5b106d6fb97b18 (MD5)","Made available in DSpace on 2011-04-13T17:37:41Z (GMT). No. of bitstreams: 1 Mangel_Allen.pdf: 14571941 bytes, checksum: 0f3f5efb85f424eeea5b106d6fb97b18 (MD5) Previous issue date: 1980"],"dc:identifier":["http://hdl.handle.net/2142/18820"],"dc:language":["en"],"dc:rights":["Copyright 1980 Allen Wayne Mangel"],"dc:subject":["Physiology","Cats","Animals"],"dc:title":["The effects of alterations in internal Ca levels on cat small intestinal slow waves"],"dc:type":["Dissertation / Thesis","text"],"thesis:degree_discipline":["Physiology"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."]},"updated_at":"2026-07-22T22:25:11Z"}