{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/16859"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/16859","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Coherence imaging technologies for the measurement of tissue and cell biomechanics","abstract":"Biomechanical properties are important for living tissues and cells. They are indicators of functional changes and pathological variations in the micro-structure, such as during tumor development. The topic of this thesis falls at the intersection of biomechanics and optical imaging, and focuses on optical elastography, an optical sensing and imaging technique used to measure biomechanical properties at the tissue and cell levels. Optical coherence elastography, multiphoton elastography, and magnetomotive microscopy are developed, demonstrated, optimized, and applied at the tissue level to ex vivo breast cancer and in vivo skin, and at the cellular level to mouse macrophages in culture. Driven by scientific needs to engineer new quantitative methods that utilize the high micro-scale resolution achievable with optics, results of biomechanical properties were obtained from the biological samples. The results suggest potential diagnostic and therapeutic clinical applications. Results from these studies also help our understanding of the relationship between biomechanical variations and tissue/cell functional changes in biological systems. Therefore, the engineering of imaging techniques is employed to investigate biomechanics, as well as the feasibility for using these techniques to solve more scientific and clinical questions.","abstract_html":"Biomechanical properties are important for living tissues and cells. They are indicators of functional changes and pathological variations in the micro-structure, such as during tumor development. The topic of this thesis falls at the intersection of biomechanics and optical imaging, and focuses on optical elastography, an optical sensing and imaging technique used to measure biomechanical properties at the tissue and cell levels. Optical coherence elastography, multiphoton elastography, and magnetomotive microscopy are developed, demonstrated, optimized, and applied at the tissue level to ex vivo breast cancer and in vivo skin, and at the cellular level to mouse macrophages in culture. Driven by scientific needs to engineer new quantitative methods that utilize the high micro-scale resolution achievable with optics, results of biomechanical properties were obtained from the biological samples. The results suggest potential diagnostic and therapeutic clinical applications. Results from these studies also help our understanding of the relationship between biomechanical variations and tissue/cell functional changes in biological systems. Therefore, the engineering of imaging techniques is employed to investigate biomechanics, as well as the feasibility for using these techniques to solve more scientific and clinical questions.","abstract_has_math":false,"creators":["Liang, Xing"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Electrical & Computer Engr","degree_department":null,"school":null,"contributors":["Boppart, Stephen A.","Eden, James G.","Insana, Michael F.","Popescu, Gabriel"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2010,"date_issued":"2010-08-20T18:00:07Z","date_published":"2010-08-20T18:00:07Z","updated_at":"2026-07-22T22:25:09Z","subjects":["optical elastography","optical coherence tomography","biomechanical property","breast tumor","skin","cell biomechanics"],"languages":["en"],"rights":["Copyright 2010 Xing Liang"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/16859","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Boppart, Stephen A.","Eden, James G.","Insana, Michael F.","Popescu, Gabriel"]},{"key":"dc:creator","label":"Author","values":["Liang, Xing"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2010-08-20T18:00:07Z","2010-08"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Electrical & Computer Engr"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["optical elastography","optical coherence tomography","biomechanical property","breast tumor","skin","cell biomechanics"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2010 Xing Liang"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/16859"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Biomechanical properties are important for living tissues and cells. 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