{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/16812"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/16812","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Nanopore technology for DNA sequencing","abstract":"Made available in DSpace on 2010-08-20T17:58:37Z (GMT). No. of bitstreams: 3 Comer_Jeffrey.zip: 226477214 bytes, checksum: 58e732aa747f3bd4da0e576ddcc65779 (MD5) Comer_Jeffrey.pdf: 19129383 bytes, checksum: be143050e3104cb300d385ce2da0c51e (MD5) license.txt: 4062 bytes, checksum: 783cef9f73d4e3c6034cca036a62f65a (MD5)","abstract_html":"Made available in DSpace on 2010-08-20T17:58:37Z (GMT). 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Some portions Copyright 2010 Springer, Copyright 2009 Biophysical Society, Copyright 2008 Oxford University Press, Copyright 2008 American Chemical Society,"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/16812"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Made available in DSpace on 2010-08-20T17:58:37Z (GMT). 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Computer simulations can assist in answering these questions by providing a means to “see” nanoscale events that cannot be imaged by any experimental method. In the development of nanopore devices for DNA sequencing, computation has played a key role in revealing how DNA behaves in the high electric field and confined geometry of a nanopore. In this dissertation, I describe my contribution to computational work for the development of nanopore-based sequencing technology. In simulations which have been corroborated by experiments, I have found that DNA adopts qualitatively different conformations in nanopores of different sizes and that nanopores of the appropriate geometry can be used to trap DNA and control its conformation. By developing a method that can provide millisecond-long current simulations with atomic resolution, I have determined conditions under which the sequence of this trapped DNA can be discriminated by ion current measurements.","Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2010-07-07T13:05:12Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 2 Comer_Jeffrey.zip: 226477214 bytes, checksum: 58e732aa747f3bd4da0e576ddcc65779 (MD5) Comer_Jeffrey.pdf: 19129383 bytes, checksum: be143050e3104cb300d385ce2da0c51e (MD5)"]},{"key":"dc:title","label":"Title","values":["Nanopore technology for DNA sequencing"]}]}],"canonical_facts":{"dc:contributor":["Aksimentiev, Aleksei","Chemla, Yann R.","Schulten, Klaus J.","Stack, John D."],"dc:creator":["Comer, Jeffrey R."],"dc:date":["2010-08-20T17:58:37Z","2010-08"],"dc:description":["Made available in DSpace on 2010-08-20T17:58:37Z (GMT). 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By developing a method that can provide millisecond-long current simulations with atomic resolution, I have determined conditions under which the sequence of this trapped DNA can be discriminated by ion current measurements.","Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2010-07-07T13:05:12Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 2 Comer_Jeffrey.zip: 226477214 bytes, checksum: 58e732aa747f3bd4da0e576ddcc65779 (MD5) Comer_Jeffrey.pdf: 19129383 bytes, checksum: be143050e3104cb300d385ce2da0c51e (MD5)"],"dc:identifier":["http://hdl.handle.net/2142/16812"],"dc:language":["en"],"dc:rights":["Copyright 2010 Jeffrey Comer. Some portions Copyright 2010 Springer, Copyright 2009 Biophysical Society, Copyright 2008 Oxford University Press, Copyright 2008 American Chemical Society,"],"dc:subject":["molecular dynamics","sequencing","DNA sequencing","nanopore","nanopore sequencing","bionanotechnology","computer simulations","force spectroscopy","nucleic acids","transmembrane transport","Brownian dynamics"],"dc:title":["Nanopore technology for DNA sequencing"],"thesis:degree_discipline":["Physics"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:25:09Z"}