{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/16151"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/16151","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Dietary guanidino acetic acid spares arginine and dietary l-homoserine spares threonine in the chick","abstract":"Guanidino acetic acid (GAA) is synthesized in the liver and kidney from Arg and Gly. It is subsequently methyllated by S-adenosylmethione to creatine. L-Homoserine (HS) has been identified as an intermediate compound in the metabolism of Thr, Met, and Asp. Bacteria, plants and yeast can synthesize Thr and Met from HS, but this has not been shown in higher organisms. Several bioassays were carried out to determine the capacity of GAA to spare dietary Arg or HS to spare dietary Thr. Crossbred chicks were fed Arg-deficient dextrose-casein (0.86% Arg), Arg-deficient corn-corn coproduct-soybean meal (1.0% Arg), Thr-deficient dextrose-casein (0.22% Thr), or Thr-deficient corn-peanut meal (0.46%) basal diets during 9-d battery feeding trials involving 5 pens of 4 chicks per treatment. Growth and gain:feed responses were obtained when GAA was added to a purified Arg-deficient diet and when HS was added to both Thr-deficient diets. In the corn-corn coproduct-soybean meal diet, GAA yielded a gain:feed response, but not an increase in gain. These results demonstrate that 0.12% supplemental GAA, like creatine, produces consistent growth and feed efficiency responses in young chicks fed Arg-deficient diets and indicate that low levels of HS (0.08-0.1%) elicit a growth and feed efficiency response in young chicks fed Thr-deficient diets.","abstract_html":"Guanidino acetic acid (GAA) is synthesized in the liver and kidney from Arg and Gly. It is subsequently methyllated by S-adenosylmethione to creatine. L-Homoserine (HS) has been identified as an intermediate compound in the metabolism of Thr, Met, and Asp. Bacteria, plants and yeast can synthesize Thr and Met from HS, but this has not been shown in higher organisms. Several bioassays were carried out to determine the capacity of GAA to spare dietary Arg or HS to spare dietary Thr. Crossbred chicks were fed Arg-deficient dextrose-casein (0.86% Arg), Arg-deficient corn-corn coproduct-soybean meal (1.0% Arg), Thr-deficient dextrose-casein (0.22% Thr), or Thr-deficient corn-peanut meal (0.46%) basal diets during 9-d battery feeding trials involving 5 pens of 4 chicks per treatment. Growth and gain:feed responses were obtained when GAA was added to a purified Arg-deficient diet and when HS was added to both Thr-deficient diets. In the corn-corn coproduct-soybean meal diet, GAA yielded a gain:feed response, but not an increase in gain. These results demonstrate that 0.12% supplemental GAA, like creatine, produces consistent growth and feed efficiency responses in young chicks fed Arg-deficient diets and indicate that low levels of HS (0.08-0.1%) elicit a growth and feed efficiency response in young chicks fed Thr-deficient diets.","abstract_has_math":false,"creators":["Bryant-Angeloni, Kasey I."],"institution":"University of Illinois at Urbana-Champaign","degree_name":"M.S.","degree_level":"Thesis","degree_discipline":"Animal Sciences","degree_department":null,"school":null,"contributors":["Parsons, Carl M.","Baker, David H."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2010,"date_issued":"2010-05-19T18:39:01Z","date_published":"2010-05-19T18:39:01Z","updated_at":"2026-07-22T22:25:08Z","subjects":["Guanidino acetic acid","L-Homoserine","spares","Arginine","Threonine","chick"],"languages":["en"],"rights":["Copyright 2010 Kasey I. Bryant-Angeloni"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/16151","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Parsons, Carl M.","Baker, David H."]},{"key":"dc:creator","label":"Author","values":["Bryant-Angeloni, Kasey I."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2010-05-19T18:39:01Z","2010-5"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Animal Sciences"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Guanidino acetic acid","L-Homoserine","spares","Arginine","Threonine","chick"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2010 Kasey I. 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Crossbred chicks were fed Arg-deficient dextrose-casein (0.86% Arg), Arg-deficient corn-corn coproduct-soybean meal (1.0% Arg), Thr-deficient dextrose-casein (0.22% Thr), or Thr-deficient corn-peanut meal (0.46%) basal diets during 9-d battery feeding trials involving 5 pens of 4 chicks per treatment. Growth and gain:feed responses were obtained when GAA was added to a purified Arg-deficient diet and when HS was added to both Thr-deficient diets. In the corn-corn coproduct-soybean meal diet, GAA yielded a gain:feed response, but not an increase in gain. These results demonstrate that 0.12% supplemental GAA, like creatine, produces consistent growth and feed efficiency responses in young chicks fed Arg-deficient diets and indicate that low levels of HS (0.08-0.1%) elicit a growth and feed efficiency response in young chicks fed Thr-deficient diets.","Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2010-04-09T15:31:44Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 2 Thesis.doc: 2073600 bytes, checksum: b3fb8c00fb241b1a5477e911c21988f8 (MD5) Bryant-Angeloni_Kasey.pdf: 524840 bytes, checksum: c244887d7160c9fbc5bc9456ad3858c6 (MD5)","Made available in DSpace on 2010-05-19T18:39:01Z (GMT). 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Several bioassays were carried out to determine the capacity of GAA to spare dietary Arg or HS to spare dietary Thr. Crossbred chicks were fed Arg-deficient dextrose-casein (0.86% Arg), Arg-deficient corn-corn coproduct-soybean meal (1.0% Arg), Thr-deficient dextrose-casein (0.22% Thr), or Thr-deficient corn-peanut meal (0.46%) basal diets during 9-d battery feeding trials involving 5 pens of 4 chicks per treatment. Growth and gain:feed responses were obtained when GAA was added to a purified Arg-deficient diet and when HS was added to both Thr-deficient diets. In the corn-corn coproduct-soybean meal diet, GAA yielded a gain:feed response, but not an increase in gain. These results demonstrate that 0.12% supplemental GAA, like creatine, produces consistent growth and feed efficiency responses in young chicks fed Arg-deficient diets and indicate that low levels of HS (0.08-0.1%) elicit a growth and feed efficiency response in young chicks fed Thr-deficient diets.","Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2010-04-09T15:31:44Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 2 Thesis.doc: 2073600 bytes, checksum: b3fb8c00fb241b1a5477e911c21988f8 (MD5) Bryant-Angeloni_Kasey.pdf: 524840 bytes, checksum: c244887d7160c9fbc5bc9456ad3858c6 (MD5)","Made available in DSpace on 2010-05-19T18:39:01Z (GMT). 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