{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/132770"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/132770","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Ion transport in multilayer solid-state nanopores for memory and biosensing applications","abstract":"Solid-state nanopores have emerged as powerful platforms for investigating nanoscale transport phenomena and single-molecule sensing, owing to their structural robustness, chemical stability, and ability to simultaneously probe ionic and in-plane currents during biomolecule translocation. This dissertation presents a comprehensive computational framework to analyze and engineer ion and biomolecule dynamics in atomically thin 2D solid-state membranes and their multilayer architectures for applications in nanofluidics, biosensing, and molecular data storage. Through molecular dynamics simulations coupled with electron transport modeling, this work focuses on the mechanisms governing asymmetric ion transport in “Janus” MoSSe nanopore membranes with pore charges and demonstrates tunable control of ion dwell times through multilayer MoSSe architectures. In addition, a multilayer MoS$_2$–hBN heterostructure is shown to effectively reduce noise in in-plane current signals, thereby improving sensing precision. Furthermore, an algorithmic framework is developed to detect and differentiate RNA tail lengths attached to double-stranded DNA, advancing the feasibility of DNA-based data storage. Together, these findings highlight how intrinsic charge asymmetry, structural engineering, and hybrid computational modeling can be employed to optimize solid-state nanopore performance for next-generation nanofluidic, sensing, and memory device applications.","abstract_html":"Solid-state nanopores have emerged as powerful platforms for investigating nanoscale transport phenomena and single-molecule sensing, owing to their structural robustness, chemical stability, and ability to simultaneously probe ionic and in-plane currents during biomolecule translocation. This dissertation presents a comprehensive computational framework to analyze and engineer ion and biomolecule dynamics in atomically thin 2D solid-state membranes and their multilayer architectures for applications in nanofluidics, biosensing, and molecular data storage. Through molecular dynamics simulations coupled with electron transport modeling, this work focuses on the mechanisms governing asymmetric ion transport in “Janus” MoSSe nanopore membranes with pore charges and demonstrates tunable control of ion dwell times through multilayer MoSSe architectures. In addition, a multilayer MoS<span class=\"etd-inline-math\"><sub>2</sub></span>–hBN heterostructure is shown to effectively reduce noise in in-plane current signals, thereby improving sensing precision. Furthermore, an algorithmic framework is developed to detect and differentiate RNA tail lengths attached to double-stranded DNA, advancing the feasibility of DNA-based data storage. Together, these findings highlight how intrinsic charge asymmetry, structural engineering, and hybrid computational modeling can be employed to optimize solid-state nanopore performance for next-generation nanofluidic, sensing, and memory device applications.","abstract_has_math":true,"creators":["Chakraborty, Rajat"],"institution":"University of Illinois Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Electrical & Computer Engr","degree_department":null,"school":null,"contributors":["Leburton, Jean-Pierre","Kim, Kyekyoon","Milenkovic, Olgica","Di Ventra, Massimiliano"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2025,"date_issued":"2025-12","date_published":"2025-12","updated_at":"2026-07-22T22:25:07Z","subjects":["Solid-state nanopore","Ion transport","Molecular dynamics simulation","Multilayer nanopore","Nanofluidics"],"languages":["en"],"rights":["Copyright 2025 Rajat Chakraborty"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/2142/132770","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Leburton, Jean-Pierre","Kim, Kyekyoon","Milenkovic, Olgica","Di Ventra, Massimiliano"]},{"key":"dc:creator","label":"Author","values":["Chakraborty, Rajat"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2025-12","2025-12-04"]},{"key":"dc:type","label":"Dc Type","values":["text","Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Electrical & Computer Engr"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Solid-state nanopore","Ion transport","Molecular dynamics simulation","Multilayer nanopore","Nanofluidics"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2025 Rajat Chakraborty"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://hdl.handle.net/2142/132770"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Solid-state nanopores have emerged as powerful platforms for investigating nanoscale transport phenomena and single-molecule sensing, owing to their structural robustness, chemical stability, and ability to simultaneously probe ionic and in-plane currents during biomolecule translocation. This dissertation presents a comprehensive computational framework to analyze and engineer ion and biomolecule dynamics in atomically thin 2D solid-state membranes and their multilayer architectures for applications in nanofluidics, biosensing, and molecular data storage. Through molecular dynamics simulations coupled with electron transport modeling, this work focuses on the mechanisms governing asymmetric ion transport in “Janus” MoSSe nanopore membranes with pore charges and demonstrates tunable control of ion dwell times through multilayer MoSSe architectures. In addition, a multilayer MoS$_2$–hBN heterostructure is shown to effectively reduce noise in in-plane current signals, thereby improving sensing precision. Furthermore, an algorithmic framework is developed to detect and differentiate RNA tail lengths attached to double-stranded DNA, advancing the feasibility of DNA-based data storage. Together, these findings highlight how intrinsic charge asymmetry, structural engineering, and hybrid computational modeling can be employed to optimize solid-state nanopore performance for next-generation nanofluidic, sensing, and memory device applications.","Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2027-12-01","The student, Rajat Chakraborty, accepted the attached license on 2025-11-20 at 21:55.","The student, Rajat Chakraborty, submitted this Dissertation for approval on 2025-11-20 at 22:14.","This Dissertation was approved for publication on 2025-12-04 at 15:30.","DSpace SAF Submission Ingestion Package generated from Vireo submission #22917 on 2026-02-19 at 20:08:55"]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Ion transport in multilayer solid-state nanopores for memory and biosensing applications"]}]}],"canonical_facts":{"dc:contributor":["Leburton, Jean-Pierre","Kim, Kyekyoon","Milenkovic, Olgica","Di Ventra, Massimiliano"],"dc:creator":["Chakraborty, Rajat"],"dc:date":["2025-12","2025-12-04"],"dc:description":["Solid-state nanopores have emerged as powerful platforms for investigating nanoscale transport phenomena and single-molecule sensing, owing to their structural robustness, chemical stability, and ability to simultaneously probe ionic and in-plane currents during biomolecule translocation. This dissertation presents a comprehensive computational framework to analyze and engineer ion and biomolecule dynamics in atomically thin 2D solid-state membranes and their multilayer architectures for applications in nanofluidics, biosensing, and molecular data storage. Through molecular dynamics simulations coupled with electron transport modeling, this work focuses on the mechanisms governing asymmetric ion transport in “Janus” MoSSe nanopore membranes with pore charges and demonstrates tunable control of ion dwell times through multilayer MoSSe architectures. In addition, a multilayer MoS$_2$–hBN heterostructure is shown to effectively reduce noise in in-plane current signals, thereby improving sensing precision. Furthermore, an algorithmic framework is developed to detect and differentiate RNA tail lengths attached to double-stranded DNA, advancing the feasibility of DNA-based data storage. Together, these findings highlight how intrinsic charge asymmetry, structural engineering, and hybrid computational modeling can be employed to optimize solid-state nanopore performance for next-generation nanofluidic, sensing, and memory device applications.","Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2027-12-01","The student, Rajat Chakraborty, accepted the attached license on 2025-11-20 at 21:55.","The student, Rajat Chakraborty, submitted this Dissertation for approval on 2025-11-20 at 22:14.","This Dissertation was approved for publication on 2025-12-04 at 15:30.","DSpace SAF Submission Ingestion Package generated from Vireo submission #22917 on 2026-02-19 at 20:08:55"],"dc:format":["application/pdf"],"dc:identifier":["https://hdl.handle.net/2142/132770"],"dc:language":["en"],"dc:rights":["Copyright 2025 Rajat Chakraborty"],"dc:subject":["Solid-state nanopore","Ion transport","Molecular dynamics simulation","Multilayer nanopore","Nanofluidics"],"dc:title":["Ion transport in multilayer solid-state nanopores for memory and biosensing applications"],"dc:type":["text","Thesis"],"thesis:degree_discipline":["Electrical & Computer Engr"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois Urbana-Champaign"]},"updated_at":"2026-07-22T22:25:07Z"}