{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/130207"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/130207","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Understanding the impact of different environmental stressors across developmental stages on the hepatic metabolome","abstract":"Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2027-08-01","abstract_html":"Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2027-08-01","abstract_has_math":false,"creators":["Gomez, Andrea Nayeli"],"institution":"University of Illinois Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Animal Sciences","degree_department":null,"school":null,"contributors":["Rodriguez-Zas, Sandra L.","Rodriguez-Zas, Sandra L","Southey, Bruce","Villamil, Maria B","McCulloch, Kathryn M."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2025,"date_issued":"2025-07-18","date_published":"2025-07-18","updated_at":"2026-07-22T22:25:06Z","subjects":["Environmental Stressors","Hepatic Metabolome","Liver Metabolism","Metabolomics","Fasting","Poly (i:c)","Maternal Immune Activation","Postnatal Stress","Liquid Chromatography-mass Spectrometry"],"languages":["en","eng"],"rights":["Copyright 2025 Andrea Gomez"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/2142/130207","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Rodriguez-Zas, Sandra L.","Rodriguez-Zas, Sandra L","Southey, Bruce","Villamil, Maria B","McCulloch, Kathryn M."]},{"key":"dc:creator","label":"Author","values":["Gomez, Andrea Nayeli"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2025-07-18","2025-08"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Animal Sciences"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Environmental Stressors","Hepatic Metabolome","Liver Metabolism","Metabolomics","Fasting","Poly (i:c)","Maternal Immune Activation","Postnatal Stress","Liquid Chromatography-mass Spectrometry"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en","eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2025 Andrea Gomez"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://hdl.handle.net/2142/130207"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2027-08-01","The student, Andrea Gomez, accepted the attached license on 2025-07-17 at 11:29.","The student, Andrea Gomez, submitted this Dissertation for approval on 2025-07-17 at 11:49.","This Dissertation was approved for publication on 2025-07-18 at 06:46.","DSpace SAF Submission Ingestion Package generated from Vireo submission #22635 on 2025-10-25 at 15:54:18","Environmental stressors during critical developmental periods can shift the metabolic trajectory of vital organs, with effects that often last well beyond the initial exposure. The liver, which manages nutrient sensing, detoxification, and immune balance, seems especially sensitive to both prenatal and postnatal disruptions. This work examined how nutritional and immune stress, before and after birth, affect liver metabolism in male and female pigs using untargeted Liquid Chromatography-Mass Spectrometry metabolomics. Short-term fasting and immune challenge each left distinct molecular signatures, but fasting had the most widespread impact, particularly on amino acid metabolism, vitamin pathways, and energy-related metabolites. When maternal immune activation was introduced as a prenatal stressor, baseline metabolic profiles were altered, and the liver’s response to postnatal challenges changed in a condition-dependent way. Many of these shifts were sex-specific, with males showing greater sensitivity in several key pathways, including one-carbon metabolism and amino acid turnover. Across different stress conditions, certain pathways like SLC-mediated transport and bile acid regulation, appeared repeatedly, which suggest that these systems may serve as shared targets of metabolic adaptation. These findings add to growing evidence that the liver’s ability to respond to stress is not fixed but shaped over time by early exposures. A better understanding of how the liver processes stress during development could help us explain why some individuals seem more vulnerable to disease later in life. This work also highlights the importance of considering both sex and timing when evaluating metabolic responses to environmental insults. In doing so, it lays the groundwork for identifying more tailored strategies to support liver health in vulnerable populations."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Understanding the impact of different environmental stressors across developmental stages on the hepatic metabolome"]}]}],"canonical_facts":{"dc:contributor":["Rodriguez-Zas, Sandra L.","Rodriguez-Zas, Sandra L","Southey, Bruce","Villamil, Maria B","McCulloch, Kathryn M."],"dc:creator":["Gomez, Andrea Nayeli"],"dc:date":["2025-07-18","2025-08"],"dc:description":["Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2027-08-01","The student, Andrea Gomez, accepted the attached license on 2025-07-17 at 11:29.","The student, Andrea Gomez, submitted this Dissertation for approval on 2025-07-17 at 11:49.","This Dissertation was approved for publication on 2025-07-18 at 06:46.","DSpace SAF Submission Ingestion Package generated from Vireo submission #22635 on 2025-10-25 at 15:54:18","Environmental stressors during critical developmental periods can shift the metabolic trajectory of vital organs, with effects that often last well beyond the initial exposure. The liver, which manages nutrient sensing, detoxification, and immune balance, seems especially sensitive to both prenatal and postnatal disruptions. This work examined how nutritional and immune stress, before and after birth, affect liver metabolism in male and female pigs using untargeted Liquid Chromatography-Mass Spectrometry metabolomics. Short-term fasting and immune challenge each left distinct molecular signatures, but fasting had the most widespread impact, particularly on amino acid metabolism, vitamin pathways, and energy-related metabolites. When maternal immune activation was introduced as a prenatal stressor, baseline metabolic profiles were altered, and the liver’s response to postnatal challenges changed in a condition-dependent way. Many of these shifts were sex-specific, with males showing greater sensitivity in several key pathways, including one-carbon metabolism and amino acid turnover. Across different stress conditions, certain pathways like SLC-mediated transport and bile acid regulation, appeared repeatedly, which suggest that these systems may serve as shared targets of metabolic adaptation. These findings add to growing evidence that the liver’s ability to respond to stress is not fixed but shaped over time by early exposures. A better understanding of how the liver processes stress during development could help us explain why some individuals seem more vulnerable to disease later in life. This work also highlights the importance of considering both sex and timing when evaluating metabolic responses to environmental insults. In doing so, it lays the groundwork for identifying more tailored strategies to support liver health in vulnerable populations."],"dc:format":["application/pdf"],"dc:identifier":["https://hdl.handle.net/2142/130207"],"dc:language":["en","eng"],"dc:rights":["Copyright 2025 Andrea Gomez"],"dc:subject":["Environmental Stressors","Hepatic Metabolome","Liver Metabolism","Metabolomics","Fasting","Poly (i:c)","Maternal Immune Activation","Postnatal Stress","Liquid Chromatography-mass Spectrometry"],"dc:title":["Understanding the impact of different environmental stressors across developmental stages on the hepatic metabolome"],"dc:type":["text"],"thesis:degree_discipline":["Animal Sciences"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois Urbana-Champaign"]},"updated_at":"2026-07-22T22:25:06Z"}