{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/129981"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/129981","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Endocrine responses to alcohol ingestion in women with and without metabolic surgery","abstract":"Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-20 without embargo terms","abstract_html":"Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-20 without embargo terms","abstract_has_math":false,"creators":["Molina Castro, Mariel"],"institution":"University of Illinois Urbana-Champaign","degree_name":"M.S.","degree_level":"Thesis","degree_discipline":"Food Science & Human Nutrition","degree_department":null,"school":null,"contributors":["Pepino, Marta Y.","Miller, Michael","Amengual, Jaume"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2025,"date_issued":"2025-07-23","date_published":"2025-07-23","updated_at":"2026-07-22T22:25:06Z","subjects":["Alcohol Use Disorder","Weight-loss Surgery","Glucose Metabolism"],"languages":["en","eng"],"rights":["Copyright 2025 Mariel Molina Castro"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/2142/129981","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Pepino, Marta Y.","Miller, Michael","Amengual, Jaume"]},{"key":"dc:creator","label":"Author","values":["Molina Castro, Mariel"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2025-07-23","2025-08"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Food Science & Human Nutrition"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Alcohol Use Disorder","Weight-loss Surgery","Glucose Metabolism"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en","eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2025 Mariel Molina Castro"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://hdl.handle.net/2142/129981"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-20 without embargo terms","The student, Mariel Molina Castro, accepted the attached license on 2025-07-23 at 10:34.","The student, Mariel Molina Castro, submitted this Thesis for approval on 2025-07-23 at 10:41.","This Thesis was approved for publication on 2025-07-23 at 14:49.","DSpace SAF Submission Ingestion Package generated from Vireo submission #22704 on 2025-10-20 at 20:15:41","Glucagon-like peptide-1 (GLP-1)-based therapies, widely used for treating obesity and type 2 diabetes, also show potential for reducing alcohol-seeking behavior. However, the effects of alcohol on endogenous GLP-1 and related peptides remain poorly understood, especially in individuals who have undergone metabolic surgery, a group at elevated risk for alcohol use disorder (AUD) despite an enhanced GLP-1 response post-surgery. This work integrates findings from cross-sectional and longitudinal placebo-controlled studies that examined the acute endocrine and glycemic effects of alcohol ingestion in women with and without a history of metabolic surgery. In the cross-sectional study, 18 post-surgical and 14 control women were assessed for hormonal and metabolic responses to an alcohol dose. Alcohol decreased GLP-1 by 34% in both groups and reduced ghrelin more in controls (27%) than in the surgery group (13%). Alcohol modestly lowered glucose and transiently increased insulin secretion in both groups. However, 28% of post-surgical women reached hypoglycemic levels, compared to none in the control group. In the longitudinal arm, seven women underwent identical alcohol/placebo challenges before and ~5 months after surgery. We observed that post-surgery, blood alcohol concentrations (BAC) peaked faster and higher, with ~28% lower alcohol clearance, likely reflecting the loss of fat-free mass. However, the acute decrease of GLP-1 and marked increase of fibroblast growth factor 21 (FGF21) following alcohol intake did not significantly differ before and after surgery. Similarly, alcohol-induced glucose reductions were not more pronounced postoperatively. Together, these findings confirm that acute alcohol consumption reduces endogenous GLP-1 and increases hypoglycemia risk after metabolic surgery. They also suggest that, despite substantial weight loss and improvements in insulin sensitivity post-surgery, acute endocrine responses to alcohol in a fasted state remain largely comparable. These insights support the relevance of gut–brain and liver–brain peptide systems in understanding alcohol's effects and AUD risk in surgical populations."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Endocrine responses to alcohol ingestion in women with and without metabolic surgery"]}]}],"canonical_facts":{"dc:contributor":["Pepino, Marta Y.","Miller, Michael","Amengual, Jaume"],"dc:creator":["Molina Castro, Mariel"],"dc:date":["2025-07-23","2025-08"],"dc:description":["Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-20 without embargo terms","The student, Mariel Molina Castro, accepted the attached license on 2025-07-23 at 10:34.","The student, Mariel Molina Castro, submitted this Thesis for approval on 2025-07-23 at 10:41.","This Thesis was approved for publication on 2025-07-23 at 14:49.","DSpace SAF Submission Ingestion Package generated from Vireo submission #22704 on 2025-10-20 at 20:15:41","Glucagon-like peptide-1 (GLP-1)-based therapies, widely used for treating obesity and type 2 diabetes, also show potential for reducing alcohol-seeking behavior. However, the effects of alcohol on endogenous GLP-1 and related peptides remain poorly understood, especially in individuals who have undergone metabolic surgery, a group at elevated risk for alcohol use disorder (AUD) despite an enhanced GLP-1 response post-surgery. This work integrates findings from cross-sectional and longitudinal placebo-controlled studies that examined the acute endocrine and glycemic effects of alcohol ingestion in women with and without a history of metabolic surgery. In the cross-sectional study, 18 post-surgical and 14 control women were assessed for hormonal and metabolic responses to an alcohol dose. Alcohol decreased GLP-1 by 34% in both groups and reduced ghrelin more in controls (27%) than in the surgery group (13%). Alcohol modestly lowered glucose and transiently increased insulin secretion in both groups. However, 28% of post-surgical women reached hypoglycemic levels, compared to none in the control group. In the longitudinal arm, seven women underwent identical alcohol/placebo challenges before and ~5 months after surgery. We observed that post-surgery, blood alcohol concentrations (BAC) peaked faster and higher, with ~28% lower alcohol clearance, likely reflecting the loss of fat-free mass. However, the acute decrease of GLP-1 and marked increase of fibroblast growth factor 21 (FGF21) following alcohol intake did not significantly differ before and after surgery. Similarly, alcohol-induced glucose reductions were not more pronounced postoperatively. Together, these findings confirm that acute alcohol consumption reduces endogenous GLP-1 and increases hypoglycemia risk after metabolic surgery. They also suggest that, despite substantial weight loss and improvements in insulin sensitivity post-surgery, acute endocrine responses to alcohol in a fasted state remain largely comparable. These insights support the relevance of gut–brain and liver–brain peptide systems in understanding alcohol's effects and AUD risk in surgical populations."],"dc:format":["application/pdf"],"dc:identifier":["https://hdl.handle.net/2142/129981"],"dc:language":["en","eng"],"dc:rights":["Copyright 2025 Mariel Molina Castro"],"dc:subject":["Alcohol Use Disorder","Weight-loss Surgery","Glucose Metabolism"],"dc:title":["Endocrine responses to alcohol ingestion in women with and without metabolic surgery"],"dc:type":["text"],"thesis:degree_discipline":["Food Science & Human Nutrition"],"thesis:degree_level":["Thesis"],"thesis:degree_name":["M.S."],"thesis:institution_name":["University of Illinois Urbana-Champaign"]},"updated_at":"2026-07-22T22:25:06Z"}