{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/129947"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/129947","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Analysis of stimuli responsive molecules: exploring pH-sensitive acid generators and redox-active molecules for electrochemical CO2 capture","abstract":"Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-20 without embargo terms","abstract_html":"Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-20 without embargo terms","abstract_has_math":false,"creators":["Roberts, Joel William"],"institution":"University of Illinois Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Chemistry","degree_department":null,"school":null,"contributors":["Zimmerman, Steven","Hergenrother, Paul","Silverman, Scott","Fratti, Rutilio"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2025,"date_issued":"2025-07-18","date_published":"2025-07-18","updated_at":"2026-07-22T22:25:06Z","subjects":["Acid Amplifier","Acid Generator","Drug Delivery","Ph","Flavin, Climate Change, Carbon Dioxide","Carbon Capture","Atr-sieras","Electrochemistry"],"languages":["en","eng"],"rights":["Copyright 2025 Joel Roberts"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/2142/129947","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Zimmerman, Steven","Hergenrother, Paul","Silverman, Scott","Fratti, Rutilio"]},{"key":"dc:creator","label":"Author","values":["Roberts, Joel William"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2025-07-18","2025-08"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemistry"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Acid Amplifier","Acid Generator","Drug Delivery","Ph","Flavin, Climate Change, Carbon Dioxide","Carbon Capture","Atr-sieras","Electrochemistry"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en","eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2025 Joel Roberts"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://hdl.handle.net/2142/129947"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-20 without embargo terms","The student, Joel Roberts, accepted the attached license on 2025-07-15 at 22:35.","The student, Joel Roberts, submitted this Dissertation for approval on 2025-07-15 at 23:00.","This Dissertation was approved for publication on 2025-07-18 at 16:37.","DSpace SAF Submission Ingestion Package generated from Vireo submission #22593 on 2025-10-20 at 20:15:19","Stimuli responsive molecules have come into focus as a mode of analyzing biological and environmental mechanisms of interests. Methods of analysis range from the chemiluminescent Schaap’s dioxetane to self-immolating polymers. Of particular interest for targeting cancer drug delivery and aiming at carbon dioxide capture are 4-chloromethylphenyl acetals and flavins, respectively. Herein, we have explored the applications of acid and voltage sensitive small molecules that can be used with the aim of challenging selective cancer drug delivery and electrochemical mediated carbon capture. We were able to use analytical methods such as NMR, LC-MS and HPLC along with generating pH-time curves to elucidate the mechanism of the hydrolysis of acid-sensitive 4-chloromethylphenyl acetals under extracellular tumor pH. We also analyzed how well an anthraquinone and flavin derivative can capture carbon dioxide under an applied voltage. We characterized these voltage sensitive molecules using cyclic voltammetry and ATR-SIERAS to explore how they capture carbon dioxide in real time. These molecular platforms may be useful in developing cancer selective drug delivery vehicles and more effective carbon capturing technologies."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Analysis of stimuli responsive molecules: exploring pH-sensitive acid generators and redox-active molecules for electrochemical CO2 capture"]}]}],"canonical_facts":{"dc:contributor":["Zimmerman, Steven","Hergenrother, Paul","Silverman, Scott","Fratti, Rutilio"],"dc:creator":["Roberts, Joel William"],"dc:date":["2025-07-18","2025-08"],"dc:description":["Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-20 without embargo terms","The student, Joel Roberts, accepted the attached license on 2025-07-15 at 22:35.","The student, Joel Roberts, submitted this Dissertation for approval on 2025-07-15 at 23:00.","This Dissertation was approved for publication on 2025-07-18 at 16:37.","DSpace SAF Submission Ingestion Package generated from Vireo submission #22593 on 2025-10-20 at 20:15:19","Stimuli responsive molecules have come into focus as a mode of analyzing biological and environmental mechanisms of interests. Methods of analysis range from the chemiluminescent Schaap’s dioxetane to self-immolating polymers. Of particular interest for targeting cancer drug delivery and aiming at carbon dioxide capture are 4-chloromethylphenyl acetals and flavins, respectively. Herein, we have explored the applications of acid and voltage sensitive small molecules that can be used with the aim of challenging selective cancer drug delivery and electrochemical mediated carbon capture. We were able to use analytical methods such as NMR, LC-MS and HPLC along with generating pH-time curves to elucidate the mechanism of the hydrolysis of acid-sensitive 4-chloromethylphenyl acetals under extracellular tumor pH. We also analyzed how well an anthraquinone and flavin derivative can capture carbon dioxide under an applied voltage. We characterized these voltage sensitive molecules using cyclic voltammetry and ATR-SIERAS to explore how they capture carbon dioxide in real time. These molecular platforms may be useful in developing cancer selective drug delivery vehicles and more effective carbon capturing technologies."],"dc:format":["application/pdf"],"dc:identifier":["https://hdl.handle.net/2142/129947"],"dc:language":["en","eng"],"dc:rights":["Copyright 2025 Joel Roberts"],"dc:subject":["Acid Amplifier","Acid Generator","Drug Delivery","Ph","Flavin, Climate Change, Carbon Dioxide","Carbon Capture","Atr-sieras","Electrochemistry"],"dc:title":["Analysis of stimuli responsive molecules: exploring pH-sensitive acid generators and redox-active molecules for electrochemical CO2 capture"],"dc:type":["text"],"thesis:degree_discipline":["Chemistry"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois Urbana-Champaign"]},"updated_at":"2026-07-22T22:25:06Z"}