{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/129892"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/129892","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Modeling the mechanics of quasi-2D biological tissues through morphological cues","abstract":"Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-20 without embargo terms","abstract_html":"Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-20 without embargo terms","abstract_has_math":false,"creators":["Nakib, Mayisha Zeb"],"institution":"University of Illinois Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Physics","degree_department":null,"school":null,"contributors":["Hilgenfeldt, Sascha","Chemla, Yann","Cooper, Lance","Leggett, Anthony"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2025,"date_issued":"2025-07-18","date_published":"2025-07-18","updated_at":"2026-07-22T22:25:06Z","subjects":["Mechanobiology","Tissue Mechanics","Morphology","Loss Of Rigidity Transition","Fluid Transition","Cell Mechanics","Biophysics","Mdck","Actin","Anisotropic Tissue","Anharmonic Elasticity"],"languages":["en","eng"],"rights":["Copyright 2025 Mayisha Zeb Nakib"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/2142/129892","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Hilgenfeldt, Sascha","Chemla, Yann","Cooper, Lance","Leggett, Anthony"]},{"key":"dc:creator","label":"Author","values":["Nakib, Mayisha Zeb"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2025-07-18","2025-08"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Physics"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Mechanobiology","Tissue Mechanics","Morphology","Loss Of Rigidity Transition","Fluid Transition","Cell Mechanics","Biophysics","Mdck","Actin","Anisotropic Tissue","Anharmonic Elasticity"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en","eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2025 Mayisha Zeb Nakib"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://hdl.handle.net/2142/129892"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-20 without embargo terms","The student, Mayisha Nakib, accepted the attached license on 2025-07-17 at 12:30.","The student, Mayisha Nakib, submitted this Dissertation for approval on 2025-07-17 at 12:39.","This Dissertation was approved for publication on 2025-07-18 at 11:11.","DSpace SAF Submission Ingestion Package generated from Vireo submission #22637 on 2025-10-20 at 16:58:48","Simple vertex models have shown that the mechanical properties of 2D space-filling domain structures (e.g., layers of foam bubbles, emulsion droplets, Voronoi tiles, etc.) are related to their morphology (both to the geometry and to the statistical organization of the domains). The present research aims at confirming the degree to which these concepts are applicable to layers of biological cells, using experimental data and modeling of epithelial tissue sheets. Preliminary results show that geometric and statistical diagnostics deviate from 2D theory, and that the cause of such deviations is mechanical stress introduced at the apical and basal sides of the cell layer. Modified modeling approaches incorporating these effects are discussed. In this work, we propose an extension of this morphological analysis to biological tissue systems by explicitly accounting for aspects of biological tissue activity as part of a theoretical model. The results greatly impact the ability to quantitatively diagnose the mechanics and stability of tissue samples non-invasively as well as to identify and potentially generate morphological tissue states having desired physical properties."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Modeling the mechanics of quasi-2D biological tissues through morphological cues"]}]}],"canonical_facts":{"dc:contributor":["Hilgenfeldt, Sascha","Chemla, Yann","Cooper, Lance","Leggett, Anthony"],"dc:creator":["Nakib, Mayisha Zeb"],"dc:date":["2025-07-18","2025-08"],"dc:description":["Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-20 without embargo terms","The student, Mayisha Nakib, accepted the attached license on 2025-07-17 at 12:30.","The student, Mayisha Nakib, submitted this Dissertation for approval on 2025-07-17 at 12:39.","This Dissertation was approved for publication on 2025-07-18 at 11:11.","DSpace SAF Submission Ingestion Package generated from Vireo submission #22637 on 2025-10-20 at 16:58:48","Simple vertex models have shown that the mechanical properties of 2D space-filling domain structures (e.g., layers of foam bubbles, emulsion droplets, Voronoi tiles, etc.) are related to their morphology (both to the geometry and to the statistical organization of the domains). The present research aims at confirming the degree to which these concepts are applicable to layers of biological cells, using experimental data and modeling of epithelial tissue sheets. Preliminary results show that geometric and statistical diagnostics deviate from 2D theory, and that the cause of such deviations is mechanical stress introduced at the apical and basal sides of the cell layer. Modified modeling approaches incorporating these effects are discussed. In this work, we propose an extension of this morphological analysis to biological tissue systems by explicitly accounting for aspects of biological tissue activity as part of a theoretical model. The results greatly impact the ability to quantitatively diagnose the mechanics and stability of tissue samples non-invasively as well as to identify and potentially generate morphological tissue states having desired physical properties."],"dc:format":["application/pdf"],"dc:identifier":["https://hdl.handle.net/2142/129892"],"dc:language":["en","eng"],"dc:rights":["Copyright 2025 Mayisha Zeb Nakib"],"dc:subject":["Mechanobiology","Tissue Mechanics","Morphology","Loss Of Rigidity Transition","Fluid Transition","Cell Mechanics","Biophysics","Mdck","Actin","Anisotropic Tissue","Anharmonic Elasticity"],"dc:title":["Modeling the mechanics of quasi-2D biological tissues through morphological cues"],"dc:type":["text"],"thesis:degree_discipline":["Physics"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois Urbana-Champaign"]},"updated_at":"2026-07-22T22:25:06Z"}