{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/129496"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/129496","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Evolution of transmission mode in a temperate virus of Pseudomonas aeruginosa and its effects on the host","abstract":"Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2027-05-01","abstract_html":"Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2027-05-01","abstract_has_math":false,"creators":["Suttenfield, Laura Catherine"],"institution":"University of Illinois Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Microbiology","degree_department":null,"school":null,"contributors":["Whitaker, Rachel J","Slauch, James M","Kuzminov, Andrei","Vanderpool, Carin"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2025,"date_issued":"2025-03-06","date_published":"2025-03-06","updated_at":"2026-07-22T22:25:05Z","subjects":["lysogen","virus","transposable phage","DMS3","Pseudomonas aeruginosa","vertical transmission"],"languages":["en","eng"],"rights":["Copyright 2025 Laura Suttenfield"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/2142/129496","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Whitaker, Rachel J","Slauch, James M","Kuzminov, Andrei","Vanderpool, Carin"]},{"key":"dc:creator","label":"Author","values":["Suttenfield, Laura Catherine"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2025-03-06","2025-05"]},{"key":"dc:type","label":"Dc Type","values":["text","Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Microbiology"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["lysogen","virus","transposable phage","DMS3","Pseudomonas aeruginosa","vertical transmission"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en","eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2025 Laura Suttenfield"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://hdl.handle.net/2142/129496"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2027-05-01","The student, Laura Suttenfield, accepted the attached license on 2025-03-01 at 23:02.","The student, Laura Suttenfield, submitted this Dissertation for approval on 2025-03-01 at 23:15.","This Dissertation was approved for publication on 2025-03-06 at 10:28.","DSpace SAF Submission Ingestion Package generated from Vireo submission #21655 on 2025-10-19 at 19:14:19","Bacteria are known for the infections they produce; that they are themselves infected is not often considered. This thesis considers the latent, lysogenic phase of a temperate virus DMS3 of the opportunistic pathogen Pseudomonas aeruginosa. In Chapter 1, I review the existing literature on how lysogeny contributes to viral fitness. In Chapter 2, we attempt to test this with deep sequencing of semi-random insertion sites. In Chapter 3, we find that spontaneous induction in lysogens causes divergent evolutionary resolutions. In Chapter 4, we take this approach to whole populations to test the way that infected and uninfected P. aeruginosa evolves in the presence of an antibiotic which can induce the lysogen. We find substantial evidence that this temperate virus impacts the evolution of its pathogen host."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Evolution of transmission mode in a temperate virus of Pseudomonas aeruginosa and its effects on the host"]}]}],"canonical_facts":{"dc:contributor":["Whitaker, Rachel J","Slauch, James M","Kuzminov, Andrei","Vanderpool, Carin"],"dc:creator":["Suttenfield, Laura Catherine"],"dc:date":["2025-03-06","2025-05"],"dc:description":["Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2027-05-01","The student, Laura Suttenfield, accepted the attached license on 2025-03-01 at 23:02.","The student, Laura Suttenfield, submitted this Dissertation for approval on 2025-03-01 at 23:15.","This Dissertation was approved for publication on 2025-03-06 at 10:28.","DSpace SAF Submission Ingestion Package generated from Vireo submission #21655 on 2025-10-19 at 19:14:19","Bacteria are known for the infections they produce; that they are themselves infected is not often considered. This thesis considers the latent, lysogenic phase of a temperate virus DMS3 of the opportunistic pathogen Pseudomonas aeruginosa. In Chapter 1, I review the existing literature on how lysogeny contributes to viral fitness. In Chapter 2, we attempt to test this with deep sequencing of semi-random insertion sites. In Chapter 3, we find that spontaneous induction in lysogens causes divergent evolutionary resolutions. In Chapter 4, we take this approach to whole populations to test the way that infected and uninfected P. aeruginosa evolves in the presence of an antibiotic which can induce the lysogen. We find substantial evidence that this temperate virus impacts the evolution of its pathogen host."],"dc:format":["application/pdf"],"dc:identifier":["https://hdl.handle.net/2142/129496"],"dc:language":["en","eng"],"dc:rights":["Copyright 2025 Laura Suttenfield"],"dc:subject":["lysogen","virus","transposable phage","DMS3","Pseudomonas aeruginosa","vertical transmission"],"dc:title":["Evolution of transmission mode in a temperate virus of Pseudomonas aeruginosa and its effects on the host"],"dc:type":["text","Thesis"],"thesis:degree_discipline":["Microbiology"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois Urbana-Champaign"]},"updated_at":"2026-07-22T22:25:05Z"}