{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/129171"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/129171","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Cerebrospinal fluid creatine kinase as a biomarker in dogs with neurologic disease","abstract":"Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-19 without embargo terms","abstract_html":"Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-19 without embargo terms","abstract_has_math":false,"creators":["Hanson, Taylor A."],"institution":"University of Illinois Urbana-Champaign","degree_name":"M.S.","degree_level":"Thesis","degree_discipline":"VMS-Veterinary Clinical Medcne","degree_department":null,"school":null,"contributors":["Foss, Kari","Rosser, Michael F","Blair, Benjamin W","Doodnaught, Graeme"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2025,"date_issued":"2025-02-28","date_published":"2025-02-28","updated_at":"2026-07-22T22:25:04Z","subjects":["cerebrospinal","CSF","creatine kinase","CK","neurologic","dog"],"languages":["en","eng"],"rights":["Copyright 2025 Taylor Hanson"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/2142/129171","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Foss, Kari","Rosser, Michael F","Blair, Benjamin W","Doodnaught, Graeme"]},{"key":"dc:creator","label":"Author","values":["Hanson, Taylor A."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2025-02-28","2025-05"]},{"key":"dc:type","label":"Dc Type","values":["text","Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["VMS-Veterinary Clinical Medcne"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["cerebrospinal","CSF","creatine kinase","CK","neurologic","dog"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en","eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2025 Taylor Hanson"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://hdl.handle.net/2142/129171"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-19 without embargo terms","The student, Taylor Hanson, accepted the attached license on 2025-02-26 at 10:42.","The student, Taylor Hanson, submitted this Thesis for approval on 2025-02-26 at 10:47.","This Thesis was approved for publication on 2025-02-28 at 16:04.","DSpace SAF Submission Ingestion Package generated from Vireo submission #21651 on 2025-10-19 at 18:09:05","While the primary utility of creatine kinase (CK) measurement in clinical practice thus far has been detection of skeletal muscle injury, it has been documented that elevated CK within cerebrospinal fluid (CSF) can similarly serve as a marker of tissue damage within the central nervous system. Furthermore, there has been much interest in the possible value of CSF CK as a prognostic indicator in cases of neurologic injury, and also as a predictor of disease etiology in cases of neurologic dysfunction. While studies in human and veterinary medicine have documented prognostic utility in specific cases, the literature remains somewhat conflicted about the value of CSF (or serum) CK as an etiologic differentiator in cases of neurologic disease. Clarity in this regard has also historically been limited by the lack of known reference intervals for CK in the CSF of veterinary species in health (though a reference interval for CSF CK in healthy dogs has recently been proposed). This study aimed first to document the magnitude of CSF CK in a small group of healthy dogs for use as a control population. Next, CSF CK was measured in a cohort of dogs with various neurologic diseases to investigate whether the magnitude of CK within the CSF could serve as a predictor of the etiologic agent of disease. Secondary investigations included evaluation of other standard CSF analytes – for example, total protein – and their association to CSF CK. No significant difference in CSF CK level was identified between the normal dogs and the neurologic dogs as a whole. Dogs with neurologic signs due to metabolic disease had significantly higher CSF CK levels than all other groups evaluated, though this finding should be interpreted with caution as only two dogs with metabolic disease were present in the study. Additionally, both age and CSF total protein were identified as significant predictors of CSF CK, with older dogs tending to have lower CSF CK and CSF CK tending to increase alongside CSF total protein. Finally, CSF CK was not found to be a significant predictor of serum CK in neurologic dogs. This research raises the possibility that dogs with neurologic disease of metabolic origin may have significantly different levels of CSF CK activity than dogs with other etiologies of neurologic disease. However, further studies – ideally with much larger sample sizes – would be required to confirm these findings and better evaluate what, if any, diagnostic benefit this biomarker may confer in a clinical setting."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Cerebrospinal fluid creatine kinase as a biomarker in dogs with neurologic disease"]}]}],"canonical_facts":{"dc:contributor":["Foss, Kari","Rosser, Michael F","Blair, Benjamin W","Doodnaught, Graeme"],"dc:creator":["Hanson, Taylor A."],"dc:date":["2025-02-28","2025-05"],"dc:description":["Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-19 without embargo terms","The student, Taylor Hanson, accepted the attached license on 2025-02-26 at 10:42.","The student, Taylor Hanson, submitted this Thesis for approval on 2025-02-26 at 10:47.","This Thesis was approved for publication on 2025-02-28 at 16:04.","DSpace SAF Submission Ingestion Package generated from Vireo submission #21651 on 2025-10-19 at 18:09:05","While the primary utility of creatine kinase (CK) measurement in clinical practice thus far has been detection of skeletal muscle injury, it has been documented that elevated CK within cerebrospinal fluid (CSF) can similarly serve as a marker of tissue damage within the central nervous system. Furthermore, there has been much interest in the possible value of CSF CK as a prognostic indicator in cases of neurologic injury, and also as a predictor of disease etiology in cases of neurologic dysfunction. While studies in human and veterinary medicine have documented prognostic utility in specific cases, the literature remains somewhat conflicted about the value of CSF (or serum) CK as an etiologic differentiator in cases of neurologic disease. Clarity in this regard has also historically been limited by the lack of known reference intervals for CK in the CSF of veterinary species in health (though a reference interval for CSF CK in healthy dogs has recently been proposed). This study aimed first to document the magnitude of CSF CK in a small group of healthy dogs for use as a control population. Next, CSF CK was measured in a cohort of dogs with various neurologic diseases to investigate whether the magnitude of CK within the CSF could serve as a predictor of the etiologic agent of disease. Secondary investigations included evaluation of other standard CSF analytes – for example, total protein – and their association to CSF CK. No significant difference in CSF CK level was identified between the normal dogs and the neurologic dogs as a whole. Dogs with neurologic signs due to metabolic disease had significantly higher CSF CK levels than all other groups evaluated, though this finding should be interpreted with caution as only two dogs with metabolic disease were present in the study. Additionally, both age and CSF total protein were identified as significant predictors of CSF CK, with older dogs tending to have lower CSF CK and CSF CK tending to increase alongside CSF total protein. Finally, CSF CK was not found to be a significant predictor of serum CK in neurologic dogs. This research raises the possibility that dogs with neurologic disease of metabolic origin may have significantly different levels of CSF CK activity than dogs with other etiologies of neurologic disease. However, further studies – ideally with much larger sample sizes – would be required to confirm these findings and better evaluate what, if any, diagnostic benefit this biomarker may confer in a clinical setting."],"dc:format":["application/pdf"],"dc:identifier":["https://hdl.handle.net/2142/129171"],"dc:language":["en","eng"],"dc:rights":["Copyright 2025 Taylor Hanson"],"dc:subject":["cerebrospinal","CSF","creatine kinase","CK","neurologic","dog"],"dc:title":["Cerebrospinal fluid creatine kinase as a biomarker in dogs with neurologic disease"],"dc:type":["text","Thesis"],"thesis:degree_discipline":["VMS-Veterinary Clinical Medcne"],"thesis:degree_level":["Thesis"],"thesis:degree_name":["M.S."],"thesis:institution_name":["University of Illinois Urbana-Champaign"]},"updated_at":"2026-07-22T22:25:04Z"}