{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/127477"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/127477","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Developing a medium-throughput collagen biomaterial model system","abstract":"Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-12-01","abstract_html":"Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-12-01","abstract_has_math":false,"creators":["Rubino, Grace Alexandra"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"M.S.","degree_level":"Thesis","degree_discipline":"Chemical Engineering","degree_department":null,"school":null,"contributors":["Harley, Brendan"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2024,"date_issued":"2024-12-11","date_published":"2024-12-11","updated_at":"2026-07-22T22:25:04Z","subjects":["Bone Regeneration","Collagen Scaffold","Hydrogel Biomaterial"],"languages":["en","eng"],"rights":["Copyright 2024 Grace A. Rubino"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/2142/127477","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Harley, Brendan"]},{"key":"dc:creator","label":"Author","values":["Rubino, Grace Alexandra"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2024-12-11","2024-12"]},{"key":"dc:type","label":"Dc Type","values":["text","Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemical Engineering"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Bone Regeneration","Collagen Scaffold","Hydrogel Biomaterial"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en","eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2024 Grace A. Rubino"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://hdl.handle.net/2142/127477"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-12-01","The student, Grace Rubino, accepted the attached license on 2024-11-29 at 09:52.","The student, Grace Rubino, submitted this Thesis for approval on 2024-11-29 at 10:07.","This Thesis was approved for publication on 2024-12-11 at 16:50.","DSpace SAF Submission Ingestion Package generated from Vireo submission #21423 on 2025-03-28 at 14:55:27","The field of biomedical research has long recognized the need to develop higher order biomaterial model systems for improved disease characterization and translational therapeutic/material progress. There is, however, difficulty in developing these workflows at the scale of conventional two-dimensional cell culture screening systems while simultaneously approaching a level of complexity necessary to consider translation to in vivo animal models. Here, we describe a three-dimensional (3D), in vitro model system to investigate the impact of stromal cell migration from one microenvironment to another at a medium-throughput scale. Importantly, we demonstrate the ability of this workflow to be utilized as a screening tool for collagen-based biomaterial motifs of interest in promoting craniomaxillofacial bone defect repair. As potential next steps in utilization of this model, we probe questions underlying a dual modification of the mechanics and chemistry of a mesh collagen scaffold design for instructing bone regeneration, potential of a collagen scaffold to be drug loaded and quantifying a release profile, and lastly investigate collagen scaffolds in a new disease and cell context for understanding fibroblast mechanobiology. These serve as a preliminary set of materials designs for potential integration into the developed model system. Overall, we explore new routes of creating medium-throughput screening workflows and illuminate new material motifs that inform fundamental and translational biologic questions."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Developing a medium-throughput collagen biomaterial model system"]}]}],"canonical_facts":{"dc:contributor":["Harley, Brendan"],"dc:creator":["Rubino, Grace Alexandra"],"dc:date":["2024-12-11","2024-12"],"dc:description":["Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-12-01","The student, Grace Rubino, accepted the attached license on 2024-11-29 at 09:52.","The student, Grace Rubino, submitted this Thesis for approval on 2024-11-29 at 10:07.","This Thesis was approved for publication on 2024-12-11 at 16:50.","DSpace SAF Submission Ingestion Package generated from Vireo submission #21423 on 2025-03-28 at 14:55:27","The field of biomedical research has long recognized the need to develop higher order biomaterial model systems for improved disease characterization and translational therapeutic/material progress. There is, however, difficulty in developing these workflows at the scale of conventional two-dimensional cell culture screening systems while simultaneously approaching a level of complexity necessary to consider translation to in vivo animal models. Here, we describe a three-dimensional (3D), in vitro model system to investigate the impact of stromal cell migration from one microenvironment to another at a medium-throughput scale. Importantly, we demonstrate the ability of this workflow to be utilized as a screening tool for collagen-based biomaterial motifs of interest in promoting craniomaxillofacial bone defect repair. As potential next steps in utilization of this model, we probe questions underlying a dual modification of the mechanics and chemistry of a mesh collagen scaffold design for instructing bone regeneration, potential of a collagen scaffold to be drug loaded and quantifying a release profile, and lastly investigate collagen scaffolds in a new disease and cell context for understanding fibroblast mechanobiology. These serve as a preliminary set of materials designs for potential integration into the developed model system. Overall, we explore new routes of creating medium-throughput screening workflows and illuminate new material motifs that inform fundamental and translational biologic questions."],"dc:format":["application/pdf"],"dc:identifier":["https://hdl.handle.net/2142/127477"],"dc:language":["en","eng"],"dc:rights":["Copyright 2024 Grace A. Rubino"],"dc:subject":["Bone Regeneration","Collagen Scaffold","Hydrogel Biomaterial"],"dc:title":["Developing a medium-throughput collagen biomaterial model system"],"dc:type":["text","Thesis"],"thesis:degree_discipline":["Chemical Engineering"],"thesis:degree_level":["Thesis"],"thesis:degree_name":["M.S."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:25:04Z"}