{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/125784"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/125784","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Analysis of participant retention issues in clinical studies","abstract":"Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-08-01","abstract_html":"Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-08-01","abstract_has_math":false,"creators":["Song, Xueze"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Business Administration","degree_department":null,"school":null,"contributors":["Mehrotra, Mili","Rajapakshe, Tharanga","Mukherjee, Ujjal","Wang, Yixin"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2024,"date_issued":"2024-07-08","date_published":"2024-07-08","updated_at":"2026-07-22T22:25:02Z","subjects":["Healthcare Operations","Clinical Study","Participant Retention","Compensation Contract","Incentive Scheme"],"languages":["en","eng"],"rights":["Copyright 2024 Xueze Song"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/2142/125784","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Mehrotra, Mili","Rajapakshe, Tharanga","Mukherjee, Ujjal","Wang, Yixin"]},{"key":"dc:creator","label":"Author","values":["Song, Xueze"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2024-07-08","2024-08"]},{"key":"dc:type","label":"Dc Type","values":["text","Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Business Administration"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Healthcare Operations","Clinical Study","Participant Retention","Compensation Contract","Incentive Scheme"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en","eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2024 Xueze Song"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://hdl.handle.net/2142/125784"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-08-01","The student, Xueze Song, accepted the attached license on 2024-07-03 at 14:44.","The student, Xueze Song, submitted this Dissertation for approval on 2024-07-03 at 15:06.","This Dissertation was approved for publication on 2024-07-08 at 10:33.","DSpace SAF Submission Ingestion Package generated from Vireo submission #20936 on 2025-02-04 at 21:25:23","Participant retention is one of the significant issues faced by clinical studies. Approximately 15% to 40% of enrolled participants drop out before studies are complete. This high dropout rate not only reduces the statistical power of a study and increases the cost of the study but also delays the development of new treatments. This thesis evaluates two strategies to improve participant retention in practice: monetary incentives to the participants and effort to reduce the inconvenience participants experience during the study. Despite the wide adoption of these strategies, there is a lack of economic analysis to understand their relative effectiveness of these strategies in improving retention, and how such strategies to improve retention can propagate and affect the study's ability to achieve its objectives. To address this gap, three research studies are conducted to provide insights into the design of retention strategies in clinical studies. The first research presents a theoretical analysis that evaluates the efficacy of different incentive schemes for providing monetary payment to the participants. This analysis reveals the performance gap of the currently adopted incentive schemes as compared to an optimal scheme and enables a decision maker to identify an optimal incentive scheme, monetary payment, and effort level for improving retention. The second research focuses on the contracts to compensate providers for their efforts in clinical studies. It investigates the impact of providers' compensation contracts on participant retention and compares the relative performances of different compensation contracts adopted in practice. It provides guidelines on when the optimal contract offers significant benefits. The third research further discusses the implications of these strategies on the termination of clinical studies. The results suggest that the adoption of different strategies to improve participant retention can also reduce the likelihood of terminating a clinical study."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Analysis of participant retention issues in clinical studies"]}]}],"canonical_facts":{"dc:contributor":["Mehrotra, Mili","Rajapakshe, Tharanga","Mukherjee, Ujjal","Wang, Yixin"],"dc:creator":["Song, Xueze"],"dc:date":["2024-07-08","2024-08"],"dc:description":["Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-08-01","The student, Xueze Song, accepted the attached license on 2024-07-03 at 14:44.","The student, Xueze Song, submitted this Dissertation for approval on 2024-07-03 at 15:06.","This Dissertation was approved for publication on 2024-07-08 at 10:33.","DSpace SAF Submission Ingestion Package generated from Vireo submission #20936 on 2025-02-04 at 21:25:23","Participant retention is one of the significant issues faced by clinical studies. Approximately 15% to 40% of enrolled participants drop out before studies are complete. This high dropout rate not only reduces the statistical power of a study and increases the cost of the study but also delays the development of new treatments. This thesis evaluates two strategies to improve participant retention in practice: monetary incentives to the participants and effort to reduce the inconvenience participants experience during the study. Despite the wide adoption of these strategies, there is a lack of economic analysis to understand their relative effectiveness of these strategies in improving retention, and how such strategies to improve retention can propagate and affect the study's ability to achieve its objectives. To address this gap, three research studies are conducted to provide insights into the design of retention strategies in clinical studies. The first research presents a theoretical analysis that evaluates the efficacy of different incentive schemes for providing monetary payment to the participants. This analysis reveals the performance gap of the currently adopted incentive schemes as compared to an optimal scheme and enables a decision maker to identify an optimal incentive scheme, monetary payment, and effort level for improving retention. The second research focuses on the contracts to compensate providers for their efforts in clinical studies. It investigates the impact of providers' compensation contracts on participant retention and compares the relative performances of different compensation contracts adopted in practice. It provides guidelines on when the optimal contract offers significant benefits. The third research further discusses the implications of these strategies on the termination of clinical studies. The results suggest that the adoption of different strategies to improve participant retention can also reduce the likelihood of terminating a clinical study."],"dc:format":["application/pdf"],"dc:identifier":["https://hdl.handle.net/2142/125784"],"dc:language":["en","eng"],"dc:rights":["Copyright 2024 Xueze Song"],"dc:subject":["Healthcare Operations","Clinical Study","Participant Retention","Compensation Contract","Incentive Scheme"],"dc:title":["Analysis of participant retention issues in clinical studies"],"dc:type":["text","Thesis"],"thesis:degree_discipline":["Business Administration"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:25:02Z"}