{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/125762"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/125762","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Nanoparticle intervention for control of cell migration","abstract":"Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-08-01","abstract_html":"Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-08-01","abstract_has_math":false,"creators":["Tetrick, Maxwell G."],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Chemistry","degree_department":null,"school":null,"contributors":["Murphy, Catherine","Chan, Jefferson","Rodriguez-Lopez, Joaquin","Sweedler, Jonathan"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2024,"date_issued":"2024-06-28","date_published":"2024-06-28","updated_at":"2026-07-22T22:25:02Z","subjects":["Gold Nanoparticles","Cell Migration","Surface Chemistry","Chemotaxis"],"languages":["en","eng"],"rights":["Copyright 2024 Maxwell Tetrick"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/2142/125762","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Murphy, Catherine","Chan, Jefferson","Rodriguez-Lopez, Joaquin","Sweedler, Jonathan"]},{"key":"dc:creator","label":"Author","values":["Tetrick, Maxwell G."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2024-06-28","2024-08"]},{"key":"dc:type","label":"Dc Type","values":["text","Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemistry"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Gold Nanoparticles","Cell Migration","Surface Chemistry","Chemotaxis"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en","eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2024 Maxwell Tetrick"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://hdl.handle.net/2142/125762"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-08-01","The student, Maxwell Tetrick, accepted the attached license on 2024-06-26 at 10:02.","The student, Maxwell Tetrick, submitted this Dissertation for approval on 2024-06-26 at 10:12.","This Dissertation was approved for publication on 2024-06-28 at 12:39.","DSpace SAF Submission Ingestion Package generated from Vireo submission #20877 on 2025-02-04 at 21:25:07","Nanoparticles exhibit remarkable physiochemical properties unique from their bulk material counterparts. Nanoparticles, and gold nanoparticles in particular, have drawn much interest for use in biomedical applications. Much of the work in the area of biological-nanoparticle interactions focuses on how changes in nanoparticle properties affect cellular uptake, cytotoxicity, and gene expression. However, it has been shown that nanoparticles can have an indirect impact on cells by changing the local microenvironment, causing a change in cell behavior. It is essential to understand the full spectrum of nanoparticle effects on biological systems to ensure safe future therapeutics. In this work, we will first discuss the basics of AuNP synthesis and the biological applications of AuNPs in Chapter 1; research on the nano-bio interface is detailed, and we explore how nanoparticles can influence biological behavior through indirect interactions with the cellular microenvironment. Chemotaxis and cell migration are discussed as a model system for studying indirect nano-bio interactions. In Chapter 2, we analyze how tuning the surface chemistry of AuNPs to have varying levels of sulfonation affects the adsorption of monocyte chemoattractant protein 1 and downstream disruption of human monocytic cell line THP-1 chemotaxis. Chapter 3 discusses our attempt to deconvolute the chemical and mechanical signaling modalities that control colorectal cancer cell HCT-116 migration. Specifically, we attempt to characterize HCT-116 migratory response to chemical and mechanical modulation of the extracellular matrix by cancer associated fibroblasts."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Nanoparticle intervention for control of cell migration"]}]}],"canonical_facts":{"dc:contributor":["Murphy, Catherine","Chan, Jefferson","Rodriguez-Lopez, Joaquin","Sweedler, Jonathan"],"dc:creator":["Tetrick, Maxwell G."],"dc:date":["2024-06-28","2024-08"],"dc:description":["Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-08-01","The student, Maxwell Tetrick, accepted the attached license on 2024-06-26 at 10:02.","The student, Maxwell Tetrick, submitted this Dissertation for approval on 2024-06-26 at 10:12.","This Dissertation was approved for publication on 2024-06-28 at 12:39.","DSpace SAF Submission Ingestion Package generated from Vireo submission #20877 on 2025-02-04 at 21:25:07","Nanoparticles exhibit remarkable physiochemical properties unique from their bulk material counterparts. Nanoparticles, and gold nanoparticles in particular, have drawn much interest for use in biomedical applications. Much of the work in the area of biological-nanoparticle interactions focuses on how changes in nanoparticle properties affect cellular uptake, cytotoxicity, and gene expression. However, it has been shown that nanoparticles can have an indirect impact on cells by changing the local microenvironment, causing a change in cell behavior. It is essential to understand the full spectrum of nanoparticle effects on biological systems to ensure safe future therapeutics. In this work, we will first discuss the basics of AuNP synthesis and the biological applications of AuNPs in Chapter 1; research on the nano-bio interface is detailed, and we explore how nanoparticles can influence biological behavior through indirect interactions with the cellular microenvironment. Chemotaxis and cell migration are discussed as a model system for studying indirect nano-bio interactions. In Chapter 2, we analyze how tuning the surface chemistry of AuNPs to have varying levels of sulfonation affects the adsorption of monocyte chemoattractant protein 1 and downstream disruption of human monocytic cell line THP-1 chemotaxis. Chapter 3 discusses our attempt to deconvolute the chemical and mechanical signaling modalities that control colorectal cancer cell HCT-116 migration. Specifically, we attempt to characterize HCT-116 migratory response to chemical and mechanical modulation of the extracellular matrix by cancer associated fibroblasts."],"dc:format":["application/pdf"],"dc:identifier":["https://hdl.handle.net/2142/125762"],"dc:language":["en","eng"],"dc:rights":["Copyright 2024 Maxwell Tetrick"],"dc:subject":["Gold Nanoparticles","Cell Migration","Surface Chemistry","Chemotaxis"],"dc:title":["Nanoparticle intervention for control of cell migration"],"dc:type":["text","Thesis"],"thesis:degree_discipline":["Chemistry"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:25:02Z"}