{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/125758"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/125758","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Rational design of activity-based sensing probes to reveal the impact of inflammation on human disease progression","abstract":"Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-08-01","abstract_html":"Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-08-01","abstract_has_math":false,"creators":["Swartchick, Chelsea Brianna"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Chemistry","degree_department":null,"school":null,"contributors":["Chan, Jefferson K","Mirica, Liviu M","Sarlah, David","Silverman, Scott K"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2024,"date_issued":"2024-06-27","date_published":"2024-06-27","updated_at":"2026-07-22T22:25:02Z","subjects":["Bioluminescence","Cancer Stem Cells","Aldehyde Dehydrogenases","Fluorescence","Hypoxia"],"languages":["en","eng"],"rights":["Copyright 2024 Chelsea Swartchick"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/2142/125758","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Chan, Jefferson K","Mirica, Liviu M","Sarlah, David","Silverman, Scott K"]},{"key":"dc:creator","label":"Author","values":["Swartchick, Chelsea Brianna"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2024-06-27","2024-08"]},{"key":"dc:type","label":"Dc Type","values":["text","Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemistry"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Bioluminescence","Cancer Stem Cells","Aldehyde Dehydrogenases","Fluorescence","Hypoxia"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en","eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2024 Chelsea Swartchick"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://hdl.handle.net/2142/125758"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-08-01","The student, Chelsea Swartchick, accepted the attached license on 2024-06-20 at 12:04.","The student, Chelsea Swartchick, submitted this Dissertation for approval on 2024-06-20 at 12:20.","This Dissertation was approved for publication on 2024-06-27 at 15:50.","DSpace SAF Submission Ingestion Package generated from Vireo submission #20856 on 2025-02-04 at 21:25:02","Molecular imaging is a powerful tool that has allowed researchers to probe complex biological phenomena. Broadly, molecular imaging relies on the partnership between a detection component and a signaling moiety. In this regard, engagement of the receptor with the target allows for signal output (e.g., light or sound). In the 2000s, the molecular imaging field advanced further with the development of activity-based sensing. This development has permitted the investigation of reactive and fleeting biological species that play important roles in both normal and disease physiology. Prior to the development of activity-based sensing, molecular imaging probes could only provide information on the presence (or absence) of an analyte. Now, tools are being generated in which the activity of the analyte is considered. Activity-based sensing probes potentiate the study of intricate biological questions previously inaccessible with standard binding- based tools. For instance, chronic inflammation has been linked to a plethora of different dynamic diseased states. In particular, both cancer and neurodegenerative disorders have been associated with an inflammatory microenvironment resulting in progression of these conditions. As such, my thesis work has been focused on the development of activity-based sensing tools to better understand the complex crosstalk between inflammation and disease progression. Chapter 1 is an introduction to molecular imaging with a particular emphasis on activity-based tool development, along with an introduction on inflammatory pathologies, specifically cancer and Alzheimer’s disease. Then, Chapter 2 is an account of the generation of a dual-activated logic-gated probe to explore the role of inflammation (via nitric-oxide) on the cancer stem cell population. Chapter 3 signifies our work in the design and synthesis of a dual-modality probe to explore how a tumor’s oxygenation status alters the stemness profile. Finally, Chapter 4 details our synthetic efforts to obtain a ratiometric photoacoustic probe for the deep tissue imaging of calcium as it relates to disease progression in Alzheimer’s disease."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Rational design of activity-based sensing probes to reveal the impact of inflammation on human disease progression"]}]}],"canonical_facts":{"dc:contributor":["Chan, Jefferson K","Mirica, Liviu M","Sarlah, David","Silverman, Scott K"],"dc:creator":["Swartchick, Chelsea Brianna"],"dc:date":["2024-06-27","2024-08"],"dc:description":["Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-08-01","The student, Chelsea Swartchick, accepted the attached license on 2024-06-20 at 12:04.","The student, Chelsea Swartchick, submitted this Dissertation for approval on 2024-06-20 at 12:20.","This Dissertation was approved for publication on 2024-06-27 at 15:50.","DSpace SAF Submission Ingestion Package generated from Vireo submission #20856 on 2025-02-04 at 21:25:02","Molecular imaging is a powerful tool that has allowed researchers to probe complex biological phenomena. Broadly, molecular imaging relies on the partnership between a detection component and a signaling moiety. In this regard, engagement of the receptor with the target allows for signal output (e.g., light or sound). In the 2000s, the molecular imaging field advanced further with the development of activity-based sensing. This development has permitted the investigation of reactive and fleeting biological species that play important roles in both normal and disease physiology. Prior to the development of activity-based sensing, molecular imaging probes could only provide information on the presence (or absence) of an analyte. Now, tools are being generated in which the activity of the analyte is considered. Activity-based sensing probes potentiate the study of intricate biological questions previously inaccessible with standard binding- based tools. For instance, chronic inflammation has been linked to a plethora of different dynamic diseased states. In particular, both cancer and neurodegenerative disorders have been associated with an inflammatory microenvironment resulting in progression of these conditions. As such, my thesis work has been focused on the development of activity-based sensing tools to better understand the complex crosstalk between inflammation and disease progression. Chapter 1 is an introduction to molecular imaging with a particular emphasis on activity-based tool development, along with an introduction on inflammatory pathologies, specifically cancer and Alzheimer’s disease. Then, Chapter 2 is an account of the generation of a dual-activated logic-gated probe to explore the role of inflammation (via nitric-oxide) on the cancer stem cell population. Chapter 3 signifies our work in the design and synthesis of a dual-modality probe to explore how a tumor’s oxygenation status alters the stemness profile. Finally, Chapter 4 details our synthetic efforts to obtain a ratiometric photoacoustic probe for the deep tissue imaging of calcium as it relates to disease progression in Alzheimer’s disease."],"dc:format":["application/pdf"],"dc:identifier":["https://hdl.handle.net/2142/125758"],"dc:language":["en","eng"],"dc:rights":["Copyright 2024 Chelsea Swartchick"],"dc:subject":["Bioluminescence","Cancer Stem Cells","Aldehyde Dehydrogenases","Fluorescence","Hypoxia"],"dc:title":["Rational design of activity-based sensing probes to reveal the impact of inflammation on human disease progression"],"dc:type":["text","Thesis"],"thesis:degree_discipline":["Chemistry"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:25:02Z"}