{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/125745"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/125745","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Expanding automated modular small molecule synthesis","abstract":"Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-08-01","abstract_html":"Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-08-01","abstract_has_math":false,"creators":["Wang, Wesley"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Chemistry","degree_department":null,"school":null,"contributors":["Burke, Martin D","Denmark, Scott E","Sarlah, David","Schroeder, Charles M"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2024,"date_issued":"2024-06-06","date_published":"2024-06-06","updated_at":"2026-07-22T22:25:02Z","subjects":["Tida Boronate","Cross-coupling","Iterative","Modular","Automation"],"languages":["en","eng"],"rights":["Copyright 2024 Wesley Wang"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/2142/125745","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Burke, Martin D","Denmark, Scott E","Sarlah, David","Schroeder, Charles M"]},{"key":"dc:creator","label":"Author","values":["Wang, Wesley"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2024-06-06","2024-08"]},{"key":"dc:type","label":"Dc Type","values":["text","Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemistry"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Tida Boronate","Cross-coupling","Iterative","Modular","Automation"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en","eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2024 Wesley Wang"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://hdl.handle.net/2142/125745"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-08-01","The student, Wesley Wang, accepted the attached license on 2024-05-13 at 12:20.","The student, Wesley Wang, submitted this Dissertation for approval on 2024-05-13 at 12:23.","This Dissertation was approved for publication on 2024-06-06 at 10:26.","DSpace SAF Submission Ingestion Package generated from Vireo submission #20790 on 2025-02-04 at 21:24:50","Small molecules are incredibly diverse, yet, accessing them is often challenging due to their complexity. Iterative cross-coupling has tremendous potential to simplify the synthesis of small molecules via repetitive connections. Recently, tremendous strides have been made towards the development of better systems for iterative cross-coupling. In this thesis, we discuss how the new TIDA boronate improves and expands accessible iterative cross-coupling space. The increased tolerance of TIDA boronates towards reaction conditions enables compatibility with superior Suzuki cross-coupling reactions that speed up automated small molecule synthesis by 10-fold. In addition, TIDA boronates enable access to previously incompatible Csp3 cross-coupling reactions, allowing for important classes of small molecules to be synthesized iteratively."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Expanding automated modular small molecule synthesis"]}]}],"canonical_facts":{"dc:contributor":["Burke, Martin D","Denmark, Scott E","Sarlah, David","Schroeder, Charles M"],"dc:creator":["Wang, Wesley"],"dc:date":["2024-06-06","2024-08"],"dc:description":["Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-08-01","The student, Wesley Wang, accepted the attached license on 2024-05-13 at 12:20.","The student, Wesley Wang, submitted this Dissertation for approval on 2024-05-13 at 12:23.","This Dissertation was approved for publication on 2024-06-06 at 10:26.","DSpace SAF Submission Ingestion Package generated from Vireo submission #20790 on 2025-02-04 at 21:24:50","Small molecules are incredibly diverse, yet, accessing them is often challenging due to their complexity. Iterative cross-coupling has tremendous potential to simplify the synthesis of small molecules via repetitive connections. Recently, tremendous strides have been made towards the development of better systems for iterative cross-coupling. In this thesis, we discuss how the new TIDA boronate improves and expands accessible iterative cross-coupling space. The increased tolerance of TIDA boronates towards reaction conditions enables compatibility with superior Suzuki cross-coupling reactions that speed up automated small molecule synthesis by 10-fold. In addition, TIDA boronates enable access to previously incompatible Csp3 cross-coupling reactions, allowing for important classes of small molecules to be synthesized iteratively."],"dc:format":["application/pdf"],"dc:identifier":["https://hdl.handle.net/2142/125745"],"dc:language":["en","eng"],"dc:rights":["Copyright 2024 Wesley Wang"],"dc:subject":["Tida Boronate","Cross-coupling","Iterative","Modular","Automation"],"dc:title":["Expanding automated modular small molecule synthesis"],"dc:type":["text","Thesis"],"thesis:degree_discipline":["Chemistry"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:25:02Z"}