{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/125600"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/125600","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Circadian rhythmicity of rat neuroendothelial cells at the blood-brain interface","abstract":"Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-02-04 without embargo terms","abstract_html":"Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-02-04 without embargo terms","abstract_has_math":false,"creators":["Weiss, Amanda C"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Molecular & Integrative Physi","degree_department":null,"school":null,"contributors":["Gillette, Martha U","Kong, Hyunjoon","Chung, Hee Jung","Sweedler, Jonathan V"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2024,"date_issued":"2024-07-11","date_published":"2024-07-11","updated_at":"2026-07-22T22:25:02Z","subjects":["Blood-brain Barrier","Circadian Rhythms","Blood-brain Interface","Blood-brain Barrier Permeability"],"languages":["en","eng"],"rights":["Copyright 2024 Amanda Weiss"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/2142/125600","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Gillette, Martha U","Kong, Hyunjoon","Chung, Hee Jung","Sweedler, Jonathan V"]},{"key":"dc:creator","label":"Author","values":["Weiss, Amanda C"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2024-07-11","2024-08"]},{"key":"dc:type","label":"Dc Type","values":["text","Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Molecular & Integrative Physi"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Blood-brain Barrier","Circadian Rhythms","Blood-brain Interface","Blood-brain Barrier Permeability"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en","eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2024 Amanda Weiss"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://hdl.handle.net/2142/125600"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-02-04 without embargo terms","The student, Amanda Weiss, accepted the attached license on 2024-07-09 at 19:38.","The student, Amanda Weiss, submitted this Dissertation for approval on 2024-07-09 at 19:57.","This Dissertation was approved for publication on 2024-07-11 at 18:09.","DSpace SAF Submission Ingestion Package generated from Vireo submission #21029 on 2025-02-04 at 21:04:50","The Blood-Brain Interface (BBI) facilitates neurological protection from pathogens, the removal of waste products, brain homeostasis, and the permeation of nutrients and drugs. Its dysfunction contributes to the onset of a variety of neurological diseases, including strokes and dementia. Research has shown that both BBI permeability and human susceptibility to strokes fluctuate according to time of day. However, more in vitro studies are required to isolate the effects of circadian rhythms from the effects of sleep and other confounding factors on BBI permeability. The role of neuroendothelial cells, a key component of the BBI, has also not been fully elucidated. We have determined that barrier tightness and permeability oscillate according to time of day in rat neuroendothelial cells. These findings extended to permeability to the blood clotting factor fibrinogen. We also determined that the addition of Carbachol, a pan-acetylcholine receptor agonist, could shift these rhythms."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Circadian rhythmicity of rat neuroendothelial cells at the blood-brain interface"]}]}],"canonical_facts":{"dc:contributor":["Gillette, Martha U","Kong, Hyunjoon","Chung, Hee Jung","Sweedler, Jonathan V"],"dc:creator":["Weiss, Amanda C"],"dc:date":["2024-07-11","2024-08"],"dc:description":["Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-02-04 without embargo terms","The student, Amanda Weiss, accepted the attached license on 2024-07-09 at 19:38.","The student, Amanda Weiss, submitted this Dissertation for approval on 2024-07-09 at 19:57.","This Dissertation was approved for publication on 2024-07-11 at 18:09.","DSpace SAF Submission Ingestion Package generated from Vireo submission #21029 on 2025-02-04 at 21:04:50","The Blood-Brain Interface (BBI) facilitates neurological protection from pathogens, the removal of waste products, brain homeostasis, and the permeation of nutrients and drugs. Its dysfunction contributes to the onset of a variety of neurological diseases, including strokes and dementia. Research has shown that both BBI permeability and human susceptibility to strokes fluctuate according to time of day. However, more in vitro studies are required to isolate the effects of circadian rhythms from the effects of sleep and other confounding factors on BBI permeability. The role of neuroendothelial cells, a key component of the BBI, has also not been fully elucidated. We have determined that barrier tightness and permeability oscillate according to time of day in rat neuroendothelial cells. These findings extended to permeability to the blood clotting factor fibrinogen. We also determined that the addition of Carbachol, a pan-acetylcholine receptor agonist, could shift these rhythms."],"dc:format":["application/pdf"],"dc:identifier":["https://hdl.handle.net/2142/125600"],"dc:language":["en","eng"],"dc:rights":["Copyright 2024 Amanda Weiss"],"dc:subject":["Blood-brain Barrier","Circadian Rhythms","Blood-brain Interface","Blood-brain Barrier Permeability"],"dc:title":["Circadian rhythmicity of rat neuroendothelial cells at the blood-brain interface"],"dc:type":["text","Thesis"],"thesis:degree_discipline":["Molecular & Integrative Physi"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:25:02Z"}