{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/124145"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/124145","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Refinement of the novel preference paradigm for young pigs","abstract":"Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2024-09-16 without embargo terms","abstract_html":"Submission original under an indefinite embargo labeled 'Open Access'. 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The submission was exported from vireo on 2024-09-16 without embargo terms","The student, Rebecca Golden, accepted the attached license on 2024-03-07 at 11:23.","The student, Rebecca Golden, submitted this Dissertation for approval on 2024-03-07 at 11:30.","This Dissertation was approved for publication on 2024-03-14 at 16:00.","DSpace SAF Submission Ingestion Package generated from Vireo submission #20236 on 2024-09-16 at 00:33:10","There are many reasons why human infants may rely on infant formula instead of breastmilk. Unfortunately, evidence has demonstrated discrepancies between formula-fed and breastfed infants, with breastfed infants outperforming their formula-fed peers in cognitive development. As such, formula companies are working to enhance their products with the goal of reducing that developmental gap. One of the main components of breastmilk is oligosaccharides, which have been shown to support intestinal, brain, and cognitive development. Infant formulas are typically formulated using bovine milk, which contains lower levels and different forms of oligosaccharides than breastmilk. As such, formula companies are funding research assessing the impact of oligosaccharide supplementation, especially in sialylated form. The pig as a biomedical model has grown more popular in recent years due to the similarities to humans, with the main similarities revolving around neuroanatomy and gastrointestinal physiology. The work in this dissertation set out to determine the impact of sialyllactose supplementation on intestinal, brain, and cognitive development. Additionally, updates were made to the main behavior test used to assess cognitive development in order to reduce data variability and increase paradigm sensitivity. We demonstrated that sialyllactose supplementation is safe and well-tolerated by the growing pig. This work also indicated minor behavioral, physiological, and anatomical differences due to supplementation. Additional work demonstrated that pigs are able to demonstrate recognition memory utilizing proper paradigm hardware and analysis techniques. The results from this work should inform future research of nutritional interventions and provide insight as to best-practices for elucidating cognitive differences in growing pigs."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Refinement of the novel preference paradigm for young pigs"]}]}],"canonical_facts":{"dc:contributor":["Dilger, Ryan N","Khan, Naiman","Schwarb, Hillary","Antonson, Adrienne"],"dc:creator":["Golden, Rebecca Kirsten"],"dc:date":["2024-05","2024-03-14"],"dc:description":["Submission original under an indefinite embargo labeled 'Open Access'. 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