{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/122219"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/122219","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Development of chemical tools for biomarker detection and targeted therapeutics for precision medicine","abstract":"Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-12-01","abstract_html":"Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-12-01","abstract_has_math":false,"creators":["Lee, Michael Chi"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Chemistry","degree_department":null,"school":null,"contributors":["Chan, Jefferson","van der Donk, Wilfred A.","Olshansky, Lisa","Mehta, Angad"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2023,"date_issued":"2023-12","date_published":"2023-12","updated_at":"2026-07-22T22:25:00Z","subjects":["Chemical Biology","Precision Medicine","Biomarker","Therapeutics","Probes","Activity-based Sensing","Biomedical Imaging","Molecular Imaging"],"languages":["en","eng"],"rights":["Copyright 2023 Michael Lee"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/2142/122219","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Chan, Jefferson","van der Donk, Wilfred A.","Olshansky, Lisa","Mehta, Angad"]},{"key":"dc:creator","label":"Author","values":["Lee, Michael Chi"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2023-12","2023-11-20"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemistry"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Chemical Biology","Precision Medicine","Biomarker","Therapeutics","Probes","Activity-based Sensing","Biomedical Imaging","Molecular Imaging"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en","eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2023 Michael Lee"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://hdl.handle.net/2142/122219"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-12-01","The student, Michael Lee, accepted the attached license on 2023-11-14 at 18:59.","The student, Michael Lee, submitted this Dissertation for approval on 2023-11-14 at 19:09.","This Dissertation was approved for publication on 2023-11-20 at 08:57.","DSpace SAF Submission Ingestion Package generated from Vireo submission #19923 on 2024-03-01 at 13:48:07","Activity-based and activatable approaches can facilitate the development of precision medicine to design better drugs and more effective treatment strategies. Activity-based sensing enables the advancement of basic science through real-time biomarker tracking in live animal models. On the clinical end, activity-based sensing improves current diagnostics for more sensitive and earlier detection of potentially life-threatening diseases, such as cancer. Through the development of activity-based and activatable chemical tools, drugs can be repurposed or redesigned to enhance efficacy and attenuate side effects. My thesis work highlights the power of reaction-based technology in the drug-development pipeline with projects to highlight each of these key clinically relevant applications. Treatment strategies can be precisely tuned to maximize efficacy by taking advantage of unique differences in disease microenvironments that exist between individuals. In Chapter 1, the core principles of molecular imaging and drug design are introduced. Chapter 2 reports on the development of a small-molecule tool that enabled the investigation of nitric oxide to establish a link between diets and cancer progression, emphasizing the importance considering lifestyle choices when a patient is diagnosed with cancer. Chapter 3 discusses the development of a multivalent targeting ligand by taking advantage of sugar transporters upregulated in cancer. The multivalent ligand was synthesized in a modular fashion to maximize generalizability. Chapter 4 highlights the development of a photo-degradable nanogel delivery system to repurpose FDA approved drugs and improve their pharmacologic properties. Finally, Chapter 5 discusses the application and protocol optimization of a small-molecule probe for both basic science research and clinical use. Each chapter describes the design rationale, characterization, and appropriate models to showcase the utility of activity-based or activatable methods."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Development of chemical tools for biomarker detection and targeted therapeutics for precision medicine"]}]}],"canonical_facts":{"dc:contributor":["Chan, Jefferson","van der Donk, Wilfred A.","Olshansky, Lisa","Mehta, Angad"],"dc:creator":["Lee, Michael Chi"],"dc:date":["2023-12","2023-11-20"],"dc:description":["Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-12-01","The student, Michael Lee, accepted the attached license on 2023-11-14 at 18:59.","The student, Michael Lee, submitted this Dissertation for approval on 2023-11-14 at 19:09.","This Dissertation was approved for publication on 2023-11-20 at 08:57.","DSpace SAF Submission Ingestion Package generated from Vireo submission #19923 on 2024-03-01 at 13:48:07","Activity-based and activatable approaches can facilitate the development of precision medicine to design better drugs and more effective treatment strategies. 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Chapter 2 reports on the development of a small-molecule tool that enabled the investigation of nitric oxide to establish a link between diets and cancer progression, emphasizing the importance considering lifestyle choices when a patient is diagnosed with cancer. Chapter 3 discusses the development of a multivalent targeting ligand by taking advantage of sugar transporters upregulated in cancer. The multivalent ligand was synthesized in a modular fashion to maximize generalizability. Chapter 4 highlights the development of a photo-degradable nanogel delivery system to repurpose FDA approved drugs and improve their pharmacologic properties. Finally, Chapter 5 discusses the application and protocol optimization of a small-molecule probe for both basic science research and clinical use. Each chapter describes the design rationale, characterization, and appropriate models to showcase the utility of activity-based or activatable methods."],"dc:format":["application/pdf"],"dc:identifier":["https://hdl.handle.net/2142/122219"],"dc:language":["en","eng"],"dc:rights":["Copyright 2023 Michael Lee"],"dc:subject":["Chemical Biology","Precision Medicine","Biomarker","Therapeutics","Probes","Activity-based Sensing","Biomedical Imaging","Molecular Imaging"],"dc:title":["Development of chemical tools for biomarker detection and targeted therapeutics for precision medicine"],"dc:type":["text"],"thesis:degree_discipline":["Chemistry"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:25:00Z"}