{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/121967"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/121967","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Dietary monoglyceride supplementation to support intestinal integrity and host defenses in health-challenged weanling pigs","abstract":"Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2024-03-01 without embargo terms","abstract_html":"Submission original under an indefinite embargo labeled &#x27;Open Access&#x27;. The submission was exported from vireo on 2024-03-01 without embargo terms","abstract_has_math":false,"creators":["White, Cameron Stephanik"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"M.S.","degree_level":"Thesis","degree_discipline":"Animal Sciences","degree_department":null,"school":null,"contributors":["Dilger, Ryan N","Donovan, Sharon M","Stein, Hans H"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2023,"date_issued":"2023-12","date_published":"2023-12","updated_at":"2026-07-22T22:25:00Z","subjects":["Monoglycerides","Etec","Nutrition","Swine"],"languages":["en","eng"],"rights":["Copyright 2023 Cameron White"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/2142/121967","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Dilger, Ryan N","Donovan, Sharon M","Stein, Hans H"]},{"key":"dc:creator","label":"Author","values":["White, Cameron Stephanik"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2023-12","2023-11-07"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Animal Sciences"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Monoglycerides","Etec","Nutrition","Swine"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en","eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2023 Cameron White"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://hdl.handle.net/2142/121967"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2024-03-01 without embargo terms","The student, Cameron White, accepted the attached license on 2023-11-01 at 11:40.","The student, Cameron White, submitted this Thesis for approval on 2023-11-01 at 11:57.","This Thesis was approved for publication on 2023-11-07 at 14:50.","DSpace SAF Submission Ingestion Package generated from Vireo submission #19881 on 2024-03-01 at 13:14:03","Frequent incidence of post-weaning enterotoxigenic Escherichia coli (ETEC) diarrhea in the swine industry contributes to high mortality rates and associated economic losses. In this study, a combination of butyric, caprylic, and capric fatty acid monoglycerides was investigated to promote intestinal integrity and host defenses in weanling pigs infected with ETEC. A total of 160 pigs were allotted to treatment groups based on weight and sex. Throughout the 17-d study, three treatment groups were maintained: sham-inoculated pigs fed a control diet [uninfected control (UC), n = 40], ETEC-inoculated pigs fed the same control diet [infected control (IC), n = 60], and ETEC-inoculated pigs fed the control diet supplemented with monoglycerides included at 0.3% of the diet [infected supplemented (MG), n = 60]. Following a 7-d acclimation period, pigs were orally inoculated on each of 3 consecutive days with either 3 mL of a sham-control (saline) or live ETEC culture (3 × 109 CFU/mL). The first day of inoculation was designated as 0 d post-inoculation (DPI), and all study outcomes reference this time-point. Fecal, tissue, and blood samples were collected from 48 individual pigs (UC, n = 12; IC, n = 18; MG, n = 18) on 5 and 10 DPI for analysis of dry matter (DM), bacterial enumeration, inflammatory markers, and intestinal permeability. ETEC-inoculated pigs in both the IC and MG groups displayed clear signs of infection including lower (P < 0.05) fecal DM and higher (P < 0.05) rectal temperatures, total bacteria, total E. coli, and total F18 ETEC during the peak infection period (5 DPI). Gene expression of the tight junction protein occludin was also decreased (P < 0.05) in both ETEC-inoculated groups at the 5 DPI time-point, indicative of increased intestinal permeability. The MG group had the numerically lowest expression of the proinflammatory cytokine IL-6 on DPI 5, but the lack of a change in other inflammatory markers makes it difficult to attribute this to potential treatment benefits. By 9 DPI, the UC and MG groups had numerically lower L:M ratios in plasma compared with the IC group, which may indicate quicker resolution of the previous damage to barrier function in the MG vs. IC group. Overall, the significant effects observed in this study were attributed to infection status and not monoglyceride supplementation."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Dietary monoglyceride supplementation to support intestinal integrity and host defenses in health-challenged weanling pigs"]}]}],"canonical_facts":{"dc:contributor":["Dilger, Ryan N","Donovan, Sharon M","Stein, Hans H"],"dc:creator":["White, Cameron Stephanik"],"dc:date":["2023-12","2023-11-07"],"dc:description":["Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2024-03-01 without embargo terms","The student, Cameron White, accepted the attached license on 2023-11-01 at 11:40.","The student, Cameron White, submitted this Thesis for approval on 2023-11-01 at 11:57.","This Thesis was approved for publication on 2023-11-07 at 14:50.","DSpace SAF Submission Ingestion Package generated from Vireo submission #19881 on 2024-03-01 at 13:14:03","Frequent incidence of post-weaning enterotoxigenic Escherichia coli (ETEC) diarrhea in the swine industry contributes to high mortality rates and associated economic losses. In this study, a combination of butyric, caprylic, and capric fatty acid monoglycerides was investigated to promote intestinal integrity and host defenses in weanling pigs infected with ETEC. A total of 160 pigs were allotted to treatment groups based on weight and sex. Throughout the 17-d study, three treatment groups were maintained: sham-inoculated pigs fed a control diet [uninfected control (UC), n = 40], ETEC-inoculated pigs fed the same control diet [infected control (IC), n = 60], and ETEC-inoculated pigs fed the control diet supplemented with monoglycerides included at 0.3% of the diet [infected supplemented (MG), n = 60]. Following a 7-d acclimation period, pigs were orally inoculated on each of 3 consecutive days with either 3 mL of a sham-control (saline) or live ETEC culture (3 × 109 CFU/mL). The first day of inoculation was designated as 0 d post-inoculation (DPI), and all study outcomes reference this time-point. Fecal, tissue, and blood samples were collected from 48 individual pigs (UC, n = 12; IC, n = 18; MG, n = 18) on 5 and 10 DPI for analysis of dry matter (DM), bacterial enumeration, inflammatory markers, and intestinal permeability. ETEC-inoculated pigs in both the IC and MG groups displayed clear signs of infection including lower (P < 0.05) fecal DM and higher (P < 0.05) rectal temperatures, total bacteria, total E. coli, and total F18 ETEC during the peak infection period (5 DPI). Gene expression of the tight junction protein occludin was also decreased (P < 0.05) in both ETEC-inoculated groups at the 5 DPI time-point, indicative of increased intestinal permeability. The MG group had the numerically lowest expression of the proinflammatory cytokine IL-6 on DPI 5, but the lack of a change in other inflammatory markers makes it difficult to attribute this to potential treatment benefits. By 9 DPI, the UC and MG groups had numerically lower L:M ratios in plasma compared with the IC group, which may indicate quicker resolution of the previous damage to barrier function in the MG vs. IC group. Overall, the significant effects observed in this study were attributed to infection status and not monoglyceride supplementation."],"dc:format":["application/pdf"],"dc:identifier":["https://hdl.handle.net/2142/121967"],"dc:language":["en","eng"],"dc:rights":["Copyright 2023 Cameron White"],"dc:subject":["Monoglycerides","Etec","Nutrition","Swine"],"dc:title":["Dietary monoglyceride supplementation to support intestinal integrity and host defenses in health-challenged weanling pigs"],"dc:type":["text"],"thesis:degree_discipline":["Animal Sciences"],"thesis:degree_level":["Thesis"],"thesis:degree_name":["M.S."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:25:00Z"}