{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/121521"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/121521","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Theoretical and computational investigations of membrane associated molecular pathology","abstract":"Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-12-04 without embargo terms","abstract_html":"Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-12-04 without embargo terms","abstract_has_math":false,"creators":["Arango, Andres Santiago"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Biophysics & Quant Biology","degree_department":null,"school":null,"contributors":["Tajkhorshid, Emad","Fratti, Rutilio","Mirica, Liviu","Pogorelov, Taras"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2023,"date_issued":"2023-08","date_published":"2023-08","updated_at":"2026-07-22T22:25:00Z","subjects":["Fusion Proteins","Membrane Destabilization","Pore Formation","Pathology","Alzheimer's Disease","Fungicides","Metabolism","Signaling","Cancer","Plasticizers","Endocrine Response","Fusion Mechanisms","Transport Mechanisms","Snare Proteins","Priming","Membranes","Boundaries","Molecular Pathology.","Simulation","Topology","Molecular Simulations","Amyloid Beta","Amphotericin","Ppar","Cyp2j2"],"languages":["en","eng"],"rights":["Copyright 2023 Andres Arango"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/2142/121521","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Tajkhorshid, Emad","Fratti, Rutilio","Mirica, Liviu","Pogorelov, Taras"]},{"key":"dc:creator","label":"Author","values":["Arango, Andres Santiago"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2023-08","2023-07-14"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Biophysics & Quant Biology"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Fusion Proteins","Membrane Destabilization","Pore Formation","Pathology","Alzheimer's Disease","Fungicides","Metabolism","Signaling","Cancer","Plasticizers","Endocrine Response","Fusion Mechanisms","Transport Mechanisms","Snare Proteins","Priming","Membranes","Boundaries","Molecular Pathology.","Simulation","Topology","Molecular Simulations","Amyloid Beta","Amphotericin","Ppar","Cyp2j2"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en","eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2023 Andres Arango"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://hdl.handle.net/2142/121521"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-12-04 without embargo terms","The student, Andres Arango, accepted the attached license on 2023-07-13 at 10:50.","The student, Andres Arango, submitted this Dissertation for approval on 2023-07-13 at 11:11.","This Dissertation was approved for publication on 2023-07-14 at 14:24.","DSpace SAF Submission Ingestion Package generated from Vireo submission #19676 on 2023-12-04 at 17:02:28","In this work we investigations membrane associated molecular pathology via a theoretical and computational approach. This work explores the use of mathematical tools from topology and molecular simulations to study membranes. These systems include amyloid beta, amphotericin, PPAR, CYP2J2, and fusion proteins. For amyloid beta, we investigate membrane destabilization and pore formation responsible for pathology in Alzheimer's disease. We probe biophysical properties of amphotericin to develop more clinically relevant fungicides. For CYP2J2, we study the mechanisms for metabolism and signaling relevant to cancer. In PPAR, the role of plasticizers are scrutinized for endocrine response. In addition, fusion and transport mechanisms are probed in the context of SNARE proteins and their priming partners. Overall, the role of membranes and boundaries are explored in molecular pathology."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Theoretical and computational investigations of membrane associated molecular pathology"]}]}],"canonical_facts":{"dc:contributor":["Tajkhorshid, Emad","Fratti, Rutilio","Mirica, Liviu","Pogorelov, Taras"],"dc:creator":["Arango, Andres Santiago"],"dc:date":["2023-08","2023-07-14"],"dc:description":["Submission original under an indefinite embargo labeled 'Open Access'. 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