{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/121455"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/121455","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Optimization of small molecule chemical tools for in vivo imaging","abstract":"Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-12-04 without embargo terms","abstract_html":"Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-12-04 without embargo terms","abstract_has_math":false,"creators":["East, Amanda K."],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Chemistry","degree_department":null,"school":null,"contributors":["Chan, Jefferson","Moore, Jeffrey S","Mitchell, Douglas A","Mirica , Liviu M"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2023,"date_issued":"2023-08","date_published":"2023-08","updated_at":"2026-07-22T22:24:57Z","subjects":["Imaging","Photoacoustic","Multimodal","Short Wave Infrared","Near Infrared","Cancer Imaging"],"languages":["en","eng"],"rights":["Copyright 2023 Amanda East"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/2142/121455","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Chan, Jefferson","Moore, Jeffrey S","Mitchell, Douglas A","Mirica , Liviu M"]},{"key":"dc:creator","label":"Author","values":["East, Amanda K."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2023-08","2023-07-11"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemistry"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Imaging","Photoacoustic","Multimodal","Short Wave Infrared","Near Infrared","Cancer Imaging"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en","eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2023 Amanda East"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://hdl.handle.net/2142/121455"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-12-04 without embargo terms","The student, Amanda East, accepted the attached license on 2023-07-04 at 16:17.","The student, Amanda East, submitted this Dissertation for approval on 2023-07-04 at 16:26.","This Dissertation was approved for publication on 2023-07-11 at 16:25.","DSpace SAF Submission Ingestion Package generated from Vireo submission #19510 on 2023-12-04 at 17:00:41","Molecular imaging is a revolutionary technique in chemical biology that allows for the detection of analytes within their native, intact biological environments. Advancements in the imaging field over the past few decades have given researchers the capability to assess and elucidate biology. Molecular imaging uses chemical tools that can selectively stain a target or interact with the target to result in an observable change. Recently, chemical tools using an activity-based sensing design have expanded upon different molecular targets by providing information about their activity rather than presence in biological systems. However, to even begin interrogating different biological systems, molecular imaging requires robust imaging agents capable of interrogating species that are deep within the body and/or species that are in low amounts. This requires the development of novel imaging platforms and optimization of those already existing, which my thesis work addresses. Therefore, Chapter 1 is an introduction to molecular imaging, emphasizes different optical imaging modalities, and provides a road map for how researchers can select different imaging modalities based on their research questions. Chapter 2 discusses the design, synthesis, and application of a novel silicon hemicyanine dye, in addition to our progress towards using the platform for activity-based sensing and remodeling the hemicyanine dye for multiplex imaging. Finally, Chapter 3 reports our work to optimize the photophysical and targeting ability of small molecule dyes via a biomimetic approach with a multivalent ligand. We specifically showcase the ligand on the aza-BODIPY platform for the sensing of copper within cancer, but the developed ligand has broad applicability to other dye platforms, molecular targets, and biological systems."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Optimization of small molecule chemical tools for in vivo imaging"]}]}],"canonical_facts":{"dc:contributor":["Chan, Jefferson","Moore, Jeffrey S","Mitchell, Douglas A","Mirica , Liviu M"],"dc:creator":["East, Amanda K."],"dc:date":["2023-08","2023-07-11"],"dc:description":["Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-12-04 without embargo terms","The student, Amanda East, accepted the attached license on 2023-07-04 at 16:17.","The student, Amanda East, submitted this Dissertation for approval on 2023-07-04 at 16:26.","This Dissertation was approved for publication on 2023-07-11 at 16:25.","DSpace SAF Submission Ingestion Package generated from Vireo submission #19510 on 2023-12-04 at 17:00:41","Molecular imaging is a revolutionary technique in chemical biology that allows for the detection of analytes within their native, intact biological environments. Advancements in the imaging field over the past few decades have given researchers the capability to assess and elucidate biology. Molecular imaging uses chemical tools that can selectively stain a target or interact with the target to result in an observable change. Recently, chemical tools using an activity-based sensing design have expanded upon different molecular targets by providing information about their activity rather than presence in biological systems. However, to even begin interrogating different biological systems, molecular imaging requires robust imaging agents capable of interrogating species that are deep within the body and/or species that are in low amounts. This requires the development of novel imaging platforms and optimization of those already existing, which my thesis work addresses. Therefore, Chapter 1 is an introduction to molecular imaging, emphasizes different optical imaging modalities, and provides a road map for how researchers can select different imaging modalities based on their research questions. Chapter 2 discusses the design, synthesis, and application of a novel silicon hemicyanine dye, in addition to our progress towards using the platform for activity-based sensing and remodeling the hemicyanine dye for multiplex imaging. Finally, Chapter 3 reports our work to optimize the photophysical and targeting ability of small molecule dyes via a biomimetic approach with a multivalent ligand. We specifically showcase the ligand on the aza-BODIPY platform for the sensing of copper within cancer, but the developed ligand has broad applicability to other dye platforms, molecular targets, and biological systems."],"dc:format":["application/pdf"],"dc:identifier":["https://hdl.handle.net/2142/121455"],"dc:language":["en","eng"],"dc:rights":["Copyright 2023 Amanda East"],"dc:subject":["Imaging","Photoacoustic","Multimodal","Short Wave Infrared","Near Infrared","Cancer Imaging"],"dc:title":["Optimization of small molecule chemical tools for in vivo imaging"],"dc:type":["text"],"thesis:degree_discipline":["Chemistry"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:24:57Z"}