{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/121324"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/121324","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Deciphering the roles of scaffold proteins (IQGAP1 and IQGAP2) and xenosensor (CAR) in liver biology","abstract":"Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-08-01","abstract_html":"Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-08-01","abstract_has_math":false,"creators":["Sen, Anushna"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Molecular & Integrative Physi","degree_department":null,"school":null,"contributors":["Anakk, Sayeepriyadarshini","Raetzman, Lori T","Tsai, Nien-Pei","Brieher, William M"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2023,"date_issued":"2023-08","date_published":"2023-08","updated_at":"2026-07-22T22:24:57Z","subjects":["Liver","Scaffold Proteins","Iqgap1","Iqgap2","Car","Nuclear Receptor","Environmental Toxicant","Pesticide","Metabolism","Insulin Signaling","Cholestasis","Liver Injury"],"languages":["en","eng"],"rights":["Copyright 2023 Anushna Sen"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/2142/121324","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Anakk, Sayeepriyadarshini","Raetzman, Lori T","Tsai, Nien-Pei","Brieher, William M"]},{"key":"dc:creator","label":"Author","values":["Sen, Anushna"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2023-08","2023-07-05"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Molecular & Integrative Physi"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Liver","Scaffold Proteins","Iqgap1","Iqgap2","Car","Nuclear Receptor","Environmental Toxicant","Pesticide","Metabolism","Insulin Signaling","Cholestasis","Liver Injury"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en","eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2023 Anushna Sen"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://hdl.handle.net/2142/121324"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-08-01","The student, Anushna Sen, accepted the attached license on 2023-06-29 at 10:19.","The student, Anushna Sen, submitted this Dissertation for approval on 2023-06-29 at 10:44.","This Dissertation was approved for publication on 2023-07-05 at 11:52.","DSpace SAF Submission Ingestion Package generated from Vireo submission #19482 on 2023-12-04 at 17:18:09","The liver is essential for bile synthesis, coordinating intermediary metabolism, energy storage, and detoxification. Its many functions routinely expose it to a wide range of insults. The liver responds and adapts to these stressors using molecular regulators such as scaffold proteins and nuclear receptors. This dissertation examines the role of scaffold proteins (IQGAP1 and IQGAP2) and a nuclear receptor (CAR) in modulating the liver’s response to physiological and pathological stressors. Chapter 2 reviews the role of nuclear receptors in combating oxidative stress within the liver. Chapter 3 investigates the role of CAR during pesticide exposure within the liver. For instance, the absence of CAR led to imidacloprid pesticide accumulation in the liver and altered detoxification gene expression. Chapter 4 examines the role of scaffold protein IQGAP2 in maintaining liver metabolic homeostasis. Analysis of Iqgap2-/- mice and IQGAP2-depleted cells revealed IQGAP2’s mechanistic role in regulating AKT, GSK3, and FOXO3 phosphorylation and subsequent hepatic glycogen accumulation during fed-state response. Chapter 5 examines the role of IQGAP1 during cholestatic injury. The absence of IQGAP1 led to increased bile acid accumulation and liver injury. Overall, these results elucidate new roles of scaffold proteins, IQGAP1 and IQGAP2, and nuclear receptor CAR in contributing to liver function in health and disease states."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Deciphering the roles of scaffold proteins (IQGAP1 and IQGAP2) and xenosensor (CAR) in liver biology"]}]}],"canonical_facts":{"dc:contributor":["Anakk, Sayeepriyadarshini","Raetzman, Lori T","Tsai, Nien-Pei","Brieher, William M"],"dc:creator":["Sen, Anushna"],"dc:date":["2023-08","2023-07-05"],"dc:description":["Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-08-01","The student, Anushna Sen, accepted the attached license on 2023-06-29 at 10:19.","The student, Anushna Sen, submitted this Dissertation for approval on 2023-06-29 at 10:44.","This Dissertation was approved for publication on 2023-07-05 at 11:52.","DSpace SAF Submission Ingestion Package generated from Vireo submission #19482 on 2023-12-04 at 17:18:09","The liver is essential for bile synthesis, coordinating intermediary metabolism, energy storage, and detoxification. Its many functions routinely expose it to a wide range of insults. The liver responds and adapts to these stressors using molecular regulators such as scaffold proteins and nuclear receptors. This dissertation examines the role of scaffold proteins (IQGAP1 and IQGAP2) and a nuclear receptor (CAR) in modulating the liver’s response to physiological and pathological stressors. Chapter 2 reviews the role of nuclear receptors in combating oxidative stress within the liver. Chapter 3 investigates the role of CAR during pesticide exposure within the liver. For instance, the absence of CAR led to imidacloprid pesticide accumulation in the liver and altered detoxification gene expression. Chapter 4 examines the role of scaffold protein IQGAP2 in maintaining liver metabolic homeostasis. Analysis of Iqgap2-/- mice and IQGAP2-depleted cells revealed IQGAP2’s mechanistic role in regulating AKT, GSK3, and FOXO3 phosphorylation and subsequent hepatic glycogen accumulation during fed-state response. Chapter 5 examines the role of IQGAP1 during cholestatic injury. The absence of IQGAP1 led to increased bile acid accumulation and liver injury. Overall, these results elucidate new roles of scaffold proteins, IQGAP1 and IQGAP2, and nuclear receptor CAR in contributing to liver function in health and disease states."],"dc:format":["application/pdf"],"dc:identifier":["https://hdl.handle.net/2142/121324"],"dc:language":["en","eng"],"dc:rights":["Copyright 2023 Anushna Sen"],"dc:subject":["Liver","Scaffold Proteins","Iqgap1","Iqgap2","Car","Nuclear Receptor","Environmental Toxicant","Pesticide","Metabolism","Insulin Signaling","Cholestasis","Liver Injury"],"dc:title":["Deciphering the roles of scaffold proteins (IQGAP1 and IQGAP2) and xenosensor (CAR) in liver biology"],"dc:type":["text"],"thesis:degree_discipline":["Molecular & Integrative Physi"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:24:57Z"}