{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/121276"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/121276","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Optimizing a 3D brain microvascular model to study radiation damage","abstract":"Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-08-01","abstract_html":"Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-08-01","abstract_has_math":false,"creators":["Ivanova, Yoanna"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"M.S.","degree_level":"Thesis","degree_discipline":"Bioengineering","degree_department":null,"school":null,"contributors":["Harley, Brendan AC"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2023,"date_issued":"2023-08","date_published":"2023-08","updated_at":"2026-07-22T22:24:57Z","subjects":["Glioblastoma","Tumor Microenvironment, Radiation","Vasculature","Hydrogel","Perivascular Niche"],"languages":["en","eng"],"rights":["Copyright 2023 Yoanna Ivanova"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/2142/121276","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Harley, Brendan AC"]},{"key":"dc:creator","label":"Author","values":["Ivanova, Yoanna"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2023-08","2023-07-19"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Bioengineering"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Glioblastoma","Tumor Microenvironment, Radiation","Vasculature","Hydrogel","Perivascular Niche"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en","eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2023 Yoanna Ivanova"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://hdl.handle.net/2142/121276"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-08-01","The student, Yoanna Ivanova, accepted the attached license on 2023-07-17 at 03:36.","The student, Yoanna Ivanova, submitted this Thesis for approval on 2023-07-17 at 03:44.","This Thesis was approved for publication on 2023-07-19 at 08:12.","DSpace SAF Submission Ingestion Package generated from Vireo submission #19705 on 2023-12-04 at 17:35:55","Glioblastoma (GBM) is a highly aggressive brain cancer characterized by diffuse metastasis at the tumor margins leading to high rates of recurrence. Radiation therapy, a standard component of current treatment, offers potential for improved patient outcomes. However, radiation therapy has opposing effects, capable of eradicating disease while also damaging normal tissue; this damage can lead to decreased quality of life and can foster a tumor-supportive microenvironment. The perivascular niche (PVN) is a microenvironment of particular interest. The PVN plays a vital role in regulating the glioblastoma stem cell population, treatment resistance, and serves as a site for cancer recurrence and migration. Understanding the impact of radiation on the PVN can better inform radiation schemes and improve our understanding of GBM recurrence. Here we optimize a previously developed three-dimensional in vitro model of the brain perivascular niche to investigate the impact of radiation dosage and delivery. We evaluated our hydrogel formulation to allow for stability, vessel growth, and network visualization. Importantly, we demonstrate that radiation effects on vessel structure can be measured in our model. This suggests our platform can provide useful insights on the effects of radiation on a short time scale relative to in vivo experiments."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Optimizing a 3D brain microvascular model to study radiation damage"]}]}],"canonical_facts":{"dc:contributor":["Harley, Brendan AC"],"dc:creator":["Ivanova, Yoanna"],"dc:date":["2023-08","2023-07-19"],"dc:description":["Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-08-01","The student, Yoanna Ivanova, accepted the attached license on 2023-07-17 at 03:36.","The student, Yoanna Ivanova, submitted this Thesis for approval on 2023-07-17 at 03:44.","This Thesis was approved for publication on 2023-07-19 at 08:12.","DSpace SAF Submission Ingestion Package generated from Vireo submission #19705 on 2023-12-04 at 17:35:55","Glioblastoma (GBM) is a highly aggressive brain cancer characterized by diffuse metastasis at the tumor margins leading to high rates of recurrence. Radiation therapy, a standard component of current treatment, offers potential for improved patient outcomes. However, radiation therapy has opposing effects, capable of eradicating disease while also damaging normal tissue; this damage can lead to decreased quality of life and can foster a tumor-supportive microenvironment. The perivascular niche (PVN) is a microenvironment of particular interest. The PVN plays a vital role in regulating the glioblastoma stem cell population, treatment resistance, and serves as a site for cancer recurrence and migration. Understanding the impact of radiation on the PVN can better inform radiation schemes and improve our understanding of GBM recurrence. Here we optimize a previously developed three-dimensional in vitro model of the brain perivascular niche to investigate the impact of radiation dosage and delivery. We evaluated our hydrogel formulation to allow for stability, vessel growth, and network visualization. Importantly, we demonstrate that radiation effects on vessel structure can be measured in our model. This suggests our platform can provide useful insights on the effects of radiation on a short time scale relative to in vivo experiments."],"dc:format":["application/pdf"],"dc:identifier":["https://hdl.handle.net/2142/121276"],"dc:language":["en","eng"],"dc:rights":["Copyright 2023 Yoanna Ivanova"],"dc:subject":["Glioblastoma","Tumor Microenvironment, Radiation","Vasculature","Hydrogel","Perivascular Niche"],"dc:title":["Optimizing a 3D brain microvascular model to study radiation damage"],"dc:type":["text"],"thesis:degree_discipline":["Bioengineering"],"thesis:degree_level":["Thesis"],"thesis:degree_name":["M.S."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:24:57Z"}