{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/121248"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/121248","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Imaging systems for minimally invasive molecular guided cancer surgeries","abstract":"Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-08-01","abstract_html":"Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-08-01","abstract_has_math":false,"creators":["George, Mebin Babu"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Electrical & Computer Engr","degree_department":null,"school":null,"contributors":["Gruev,, Viktor","Kim, Kyekyoon","Nie, Shuming","Choi, Hyungsoo"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2023,"date_issued":"2023-08","date_published":"2023-08","updated_at":"2026-07-22T22:24:57Z","subjects":["Fluorescence Guided Surgery","Cancer Surgery","Endoscopy","Minimally Invasive Surgery","Photobleaching","Image Sensors","Augmented Reality"],"languages":["en","eng"],"rights":["Copyright 2023 Mebin Babu George"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/2142/121248","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Gruev,, Viktor","Kim, Kyekyoon","Nie, Shuming","Choi, Hyungsoo"]},{"key":"dc:creator","label":"Author","values":["George, Mebin Babu"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2023-08","2023-07-11"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Electrical & Computer Engr"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Fluorescence Guided Surgery","Cancer Surgery","Endoscopy","Minimally Invasive Surgery","Photobleaching","Image Sensors","Augmented Reality"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en","eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2023 Mebin Babu George"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://hdl.handle.net/2142/121248"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-08-01","The student, Mebin Babu George, accepted the attached license on 2023-07-10 at 17:05.","The student, Mebin Babu George, submitted this Dissertation for approval on 2023-07-10 at 17:19.","This Dissertation was approved for publication on 2023-07-11 at 15:32.","DSpace SAF Submission Ingestion Package generated from Vireo submission #19608 on 2023-12-04 at 17:33:07","Cancer continues to pose a significant threat to the lives of millions of people worldwide. In addition to causing physical distress to the patients from standard regimen, it also impacts their social life and emotional state due to fear of resurgence, grief, and depression. Early detection is critical for a high five-year survival rate and timely treatment. Among many modalities available today to improve cancer treatment, intraoperative near-infrared molecular imaging used in conjunction with endoscopic surveillance and surgeries is emerging as a promising approach that could enable timely detection of cancer. It combines the benefits of using highly specific tumor targeted probes and enhanced visualization of the surgical site in real-time during surveillance or surgery, potentially improving patient outcomes. Despite the gains provided by this novel multimodal platform, there are several limitations that could impede its effectiveness. These challenges include inter- and intra- tumor heterogeneity which could limit the efficacy of systems optimized to detect a single probe, risk of photobleaching during surgical manipulation of the endoscope that could result in failure to detect cancer, and potential damage to vital structures due to reduced perception of depth from visualizing fluorescence information on 2D-displays. This dissertation proposes addressing these challenges mainly by using two endoscopic systems. The first one features multiple probe imaging using a single-chip imaging sensor to enhance the sensitivity and specificity of cancer detection, while the latter detects a single tracer but exhibits high sensitivity to reduce the risk of probe photobleaching. A third system, which utilizes a holographic display to enhance depth perception during cancer surgery, is also presented."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Imaging systems for minimally invasive molecular guided cancer surgeries"]}]}],"canonical_facts":{"dc:contributor":["Gruev,, Viktor","Kim, Kyekyoon","Nie, Shuming","Choi, Hyungsoo"],"dc:creator":["George, Mebin Babu"],"dc:date":["2023-08","2023-07-11"],"dc:description":["Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-08-01","The student, Mebin Babu George, accepted the attached license on 2023-07-10 at 17:05.","The student, Mebin Babu George, submitted this Dissertation for approval on 2023-07-10 at 17:19.","This Dissertation was approved for publication on 2023-07-11 at 15:32.","DSpace SAF Submission Ingestion Package generated from Vireo submission #19608 on 2023-12-04 at 17:33:07","Cancer continues to pose a significant threat to the lives of millions of people worldwide. In addition to causing physical distress to the patients from standard regimen, it also impacts their social life and emotional state due to fear of resurgence, grief, and depression. Early detection is critical for a high five-year survival rate and timely treatment. Among many modalities available today to improve cancer treatment, intraoperative near-infrared molecular imaging used in conjunction with endoscopic surveillance and surgeries is emerging as a promising approach that could enable timely detection of cancer. It combines the benefits of using highly specific tumor targeted probes and enhanced visualization of the surgical site in real-time during surveillance or surgery, potentially improving patient outcomes. Despite the gains provided by this novel multimodal platform, there are several limitations that could impede its effectiveness. These challenges include inter- and intra- tumor heterogeneity which could limit the efficacy of systems optimized to detect a single probe, risk of photobleaching during surgical manipulation of the endoscope that could result in failure to detect cancer, and potential damage to vital structures due to reduced perception of depth from visualizing fluorescence information on 2D-displays. This dissertation proposes addressing these challenges mainly by using two endoscopic systems. The first one features multiple probe imaging using a single-chip imaging sensor to enhance the sensitivity and specificity of cancer detection, while the latter detects a single tracer but exhibits high sensitivity to reduce the risk of probe photobleaching. A third system, which utilizes a holographic display to enhance depth perception during cancer surgery, is also presented."],"dc:format":["application/pdf"],"dc:identifier":["https://hdl.handle.net/2142/121248"],"dc:language":["en","eng"],"dc:rights":["Copyright 2023 Mebin Babu George"],"dc:subject":["Fluorescence Guided Surgery","Cancer Surgery","Endoscopy","Minimally Invasive Surgery","Photobleaching","Image Sensors","Augmented Reality"],"dc:title":["Imaging systems for minimally invasive molecular guided cancer surgeries"],"dc:type":["text"],"thesis:degree_discipline":["Electrical & Computer Engr"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:24:57Z"}