{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/120554"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/120554","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Structure and dynamics of biomolecular and bioinspired nanomaterials: from electron microscopy to videography","abstract":"Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-05-01","abstract_html":"Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-05-01","abstract_has_math":false,"creators":["Smith, John W."],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Materials Science & Engr","degree_department":null,"school":null,"contributors":["Chen, Qian","Schroeder, Charles","Tajkhorshid, Emad","Wang, Hua"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2023,"date_issued":"2023-05","date_published":"2023-05","updated_at":"2026-07-22T22:24:57Z","subjects":["Electron Microscopy","Bioimaging","Materials Science","Nanomaterials","Biophysics","Molecular Physics"],"languages":["en","eng"],"rights":["Copyright 2023 John Smith"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/2142/120554","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Chen, Qian","Schroeder, Charles","Tajkhorshid, Emad","Wang, Hua"]},{"key":"dc:creator","label":"Author","values":["Smith, John W."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2023-05","2023-04-27"]},{"key":"dc:type","label":"Dc Type","values":["text","Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Materials Science & Engr"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Electron Microscopy","Bioimaging","Materials Science","Nanomaterials","Biophysics","Molecular Physics"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en","eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2023 John Smith"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://hdl.handle.net/2142/120554"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-05-01","The student, John Smith, accepted the attached license on 2023-04-25 at 11:50.","The student, John Smith, submitted this Dissertation for approval on 2023-04-25 at 12:05.","This Dissertation was approved for publication on 2023-04-27 at 13:04.","DSpace SAF Submission Ingestion Package generated from Vireo submission #19143 on 2023-09-01 at 17:21:34","The world of soft nanomaterials is a world in motion. While this sentiment may first bring terms like “squish”, “flow”, and “deform” to mind, the reality is far richer. Soft and biological materials transform and transport, react and replicate, conduct, catalyze, communicate, and live, all through the execution of well-crafted, nanoscopic, molecular dances. Even the jiggling and jostling of molecules at equilibrium tells a story, about the fundamental physics holding their world together. The work described in this thesis has been motivated by the desire to improve fundamental understanding of the structure and dynamics of soft nanomaterials by seeing them, in particular, by developing new experimental methods and supporting quantitative, analytical tools that make it possible to interrogate and quantify these two attributes with direct, high-resolution imaging. The core of the approach has been electron microscopy (EM), providing the essential ingredient of nanometer spatial resolution, but the endeavor as a whole has taken EM to new and little-explored territories when it comes to soft materials characterization. In going from EM in two dimensions to three, it is revealed how rationally designed polymers can dismantle protein aggregates that contribute to disease, and how filtration membranes that have been in use for nearly sixty years develop their intricate structures and function. In going from conventional, snapshot-based imaging to real-time “videography” in a liquid environment, it is shown how lipids and proteins interact in biological membranes and how polymer networks adapt and transform in response to environmental changes, to manage water or deliver therapeutics. The toolbox assembled along the way is highly generalizable, and thus hopefully provides a stepping stone on the path to fundamental understanding of soft condensed matter in areas well beyond the systems described here. As the saying goes, “seeing is believing”, and there remains much to be uncovered in the molecular world as microscopy pushes ever further into this domain."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Structure and dynamics of biomolecular and bioinspired nanomaterials: from electron microscopy to videography"]}]}],"canonical_facts":{"dc:contributor":["Chen, Qian","Schroeder, Charles","Tajkhorshid, Emad","Wang, Hua"],"dc:creator":["Smith, John W."],"dc:date":["2023-05","2023-04-27"],"dc:description":["Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-05-01","The student, John Smith, accepted the attached license on 2023-04-25 at 11:50.","The student, John Smith, submitted this Dissertation for approval on 2023-04-25 at 12:05.","This Dissertation was approved for publication on 2023-04-27 at 13:04.","DSpace SAF Submission Ingestion Package generated from Vireo submission #19143 on 2023-09-01 at 17:21:34","The world of soft nanomaterials is a world in motion. While this sentiment may first bring terms like “squish”, “flow”, and “deform” to mind, the reality is far richer. Soft and biological materials transform and transport, react and replicate, conduct, catalyze, communicate, and live, all through the execution of well-crafted, nanoscopic, molecular dances. Even the jiggling and jostling of molecules at equilibrium tells a story, about the fundamental physics holding their world together. The work described in this thesis has been motivated by the desire to improve fundamental understanding of the structure and dynamics of soft nanomaterials by seeing them, in particular, by developing new experimental methods and supporting quantitative, analytical tools that make it possible to interrogate and quantify these two attributes with direct, high-resolution imaging. The core of the approach has been electron microscopy (EM), providing the essential ingredient of nanometer spatial resolution, but the endeavor as a whole has taken EM to new and little-explored territories when it comes to soft materials characterization. In going from EM in two dimensions to three, it is revealed how rationally designed polymers can dismantle protein aggregates that contribute to disease, and how filtration membranes that have been in use for nearly sixty years develop their intricate structures and function. In going from conventional, snapshot-based imaging to real-time “videography” in a liquid environment, it is shown how lipids and proteins interact in biological membranes and how polymer networks adapt and transform in response to environmental changes, to manage water or deliver therapeutics. The toolbox assembled along the way is highly generalizable, and thus hopefully provides a stepping stone on the path to fundamental understanding of soft condensed matter in areas well beyond the systems described here. As the saying goes, “seeing is believing”, and there remains much to be uncovered in the molecular world as microscopy pushes ever further into this domain."],"dc:format":["application/pdf"],"dc:identifier":["https://hdl.handle.net/2142/120554"],"dc:language":["en","eng"],"dc:rights":["Copyright 2023 John Smith"],"dc:subject":["Electron Microscopy","Bioimaging","Materials Science","Nanomaterials","Biophysics","Molecular Physics"],"dc:title":["Structure and dynamics of biomolecular and bioinspired nanomaterials: from electron microscopy to videography"],"dc:type":["text","Thesis"],"thesis:degree_discipline":["Materials Science & Engr"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:24:57Z"}