{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/117877"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/117877","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"The food matrix and its effect on human protein metabolism","abstract":"Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-05-11 without embargo terms","abstract_html":"Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-05-11 without embargo terms","abstract_has_math":false,"creators":["Paulussen, Kevin Johannes Maria"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Kinesiology","degree_department":null,"school":null,"contributors":["Burd, Nicholas A.","Moore, Daniel R.","Wilund, Kenneth R.","Allen, Jacob M."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2022,"date_issued":"2022-05","date_published":"2022-05","updated_at":"2026-07-22T22:24:56Z","subjects":["Muscle","Hypertrophy","Protein Synthesis","Protein Breakdown","Whole Food","Food Matrix","Protein Oxidation","Exercise","Protein Quality","Protease","Dipeptide","Dileucine","Salmon","Leucine","mTORC1","Plant Protein"],"languages":["en","eng"],"rights":["Copyright 2022 Kevin Johannes Maria Paulussen"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/2142/117877","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Burd, Nicholas A.","Moore, Daniel R.","Wilund, Kenneth R.","Allen, Jacob M."]},{"key":"dc:creator","label":"Author","values":["Paulussen, Kevin Johannes Maria"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2022-05","2022-04-22"]},{"key":"dc:type","label":"Dc Type","values":["text","Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Kinesiology"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Muscle","Hypertrophy","Protein Synthesis","Protein Breakdown","Whole Food","Food Matrix","Protein Oxidation","Exercise","Protein Quality","Protease","Dipeptide","Dileucine","Salmon","Leucine","mTORC1","Plant Protein"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en","eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2022 Kevin Johannes Maria Paulussen"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://hdl.handle.net/2142/117877"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-05-11 without embargo terms","The student, Kevin Johannes Maria Paulussen, accepted the attached license on 2022-04-15 at 20:26.","The student, Kevin Johannes Maria Paulussen, submitted this Dissertation for approval on 2022-04-15 at 20:54.","This Dissertation was approved for publication on 2022-04-22 at 07:56.","DSpace SAF Submission Ingestion Package generated from Vireo submission #17720 on 2023-05-11 at 16:57:47","Skeletal muscle plays a vital role in human health and disease prevention. Dietary protein is a main anabolic stimulus and thus essential for the maintenance of skeletal muscle mass. Most research on the effects of dietary protein on muscle protein turnover (synthesis and breakdown) have been investigated from a reductionist viewpoint utilizing isolated nutrients. Dietary recommendations to support muscle mass are based on these studies, which have been extrapolated to generalize to the diet in its entirety. While many early studies provided the framework for future directions, it is important to recognize that diets do not consist of isolated nutrients. Evidence suggests that the food matrix, a term to describe both the nutrient and non-nutrient components of whole foods, may play an important role in the regulation of muscle protein turnover. The studies reported in this dissertation investigated aspects of the food matrix as it relates to muscle protein turnover and health. In study 1, we showed that salmon ingestion is as potent for the stimulation of muscle protein synthesis rates as the sum of its isolated nutrients. In study 2, we demonstrated that an isolated food component, di-leucine, was more effective for the stimulation of muscle protein synthesis rates when compared to leucine. In study 3, we assessed the efficacy of the co-ingestion of a microbial protease blend with isolated pea protein and demonstrated greater plasma postprandial essential and total amino acid concentrations when compared to ingestion of pea protein alone. The studies contained in this dissertation investigated aspects of the food matrix including nutrient-nutrient interactions (salmon vs. isolated nutrients), isolated food components (dileucine) and manipulation of food structure (via a microbial protease supplement) in the regulation of human muscle protein turnover and underline the necessity of a more holistic view when it comes to dietary regulation of skeletal muscle mass."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["The food matrix and its effect on human protein metabolism"]}]}],"canonical_facts":{"dc:contributor":["Burd, Nicholas A.","Moore, Daniel R.","Wilund, Kenneth R.","Allen, Jacob M."],"dc:creator":["Paulussen, Kevin Johannes Maria"],"dc:date":["2022-05","2022-04-22"],"dc:description":["Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-05-11 without embargo terms","The student, Kevin Johannes Maria Paulussen, accepted the attached license on 2022-04-15 at 20:26.","The student, Kevin Johannes Maria Paulussen, submitted this Dissertation for approval on 2022-04-15 at 20:54.","This Dissertation was approved for publication on 2022-04-22 at 07:56.","DSpace SAF Submission Ingestion Package generated from Vireo submission #17720 on 2023-05-11 at 16:57:47","Skeletal muscle plays a vital role in human health and disease prevention. Dietary protein is a main anabolic stimulus and thus essential for the maintenance of skeletal muscle mass. Most research on the effects of dietary protein on muscle protein turnover (synthesis and breakdown) have been investigated from a reductionist viewpoint utilizing isolated nutrients. Dietary recommendations to support muscle mass are based on these studies, which have been extrapolated to generalize to the diet in its entirety. While many early studies provided the framework for future directions, it is important to recognize that diets do not consist of isolated nutrients. Evidence suggests that the food matrix, a term to describe both the nutrient and non-nutrient components of whole foods, may play an important role in the regulation of muscle protein turnover. The studies reported in this dissertation investigated aspects of the food matrix as it relates to muscle protein turnover and health. In study 1, we showed that salmon ingestion is as potent for the stimulation of muscle protein synthesis rates as the sum of its isolated nutrients. In study 2, we demonstrated that an isolated food component, di-leucine, was more effective for the stimulation of muscle protein synthesis rates when compared to leucine. In study 3, we assessed the efficacy of the co-ingestion of a microbial protease blend with isolated pea protein and demonstrated greater plasma postprandial essential and total amino acid concentrations when compared to ingestion of pea protein alone. The studies contained in this dissertation investigated aspects of the food matrix including nutrient-nutrient interactions (salmon vs. isolated nutrients), isolated food components (dileucine) and manipulation of food structure (via a microbial protease supplement) in the regulation of human muscle protein turnover and underline the necessity of a more holistic view when it comes to dietary regulation of skeletal muscle mass."],"dc:format":["application/pdf"],"dc:identifier":["https://hdl.handle.net/2142/117877"],"dc:language":["en","eng"],"dc:rights":["Copyright 2022 Kevin Johannes Maria Paulussen"],"dc:subject":["Muscle","Hypertrophy","Protein Synthesis","Protein Breakdown","Whole Food","Food Matrix","Protein Oxidation","Exercise","Protein Quality","Protease","Dipeptide","Dileucine","Salmon","Leucine","mTORC1","Plant Protein"],"dc:title":["The food matrix and its effect on human protein metabolism"],"dc:type":["text","Thesis"],"thesis:degree_discipline":["Kinesiology"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:24:56Z"}