{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/117554"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/117554","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Nuclear receptor TLX and dietary habits: Identifying new targets for the treatment and prevention of metastatic breast cancer","abstract":"Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-12-01","abstract_html":"Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-12-01","abstract_has_math":false,"creators":["Nelczyk, Adam Tyler"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Molecular & Integrative Physi","degree_department":null,"school":null,"contributors":["Nelson, Erik R","Katzenellenbogen, Benita","Spinella, Michael J","Madak-Erdogan, Zeynep"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2022,"date_issued":"2022-12","date_published":"2022-12","updated_at":"2026-07-22T22:24:56Z","subjects":["Nuclear Receptor","Tlx","Nr2e1","Breast Cancer","Metastasis","Tumor Dormancy","High-cholesterol","Cured","Fried","Bacon","Histamines","Mast Cells"],"languages":["en","eng"],"rights":["Copyright 2022 Adam Nelczyk"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/2142/117554","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Nelson, Erik R","Katzenellenbogen, Benita","Spinella, Michael J","Madak-Erdogan, Zeynep"]},{"key":"dc:creator","label":"Author","values":["Nelczyk, Adam Tyler"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2022-12","2022-11-21"]},{"key":"dc:type","label":"Dc Type","values":["text","Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Molecular & Integrative Physi"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Nuclear Receptor","Tlx","Nr2e1","Breast Cancer","Metastasis","Tumor Dormancy","High-cholesterol","Cured","Fried","Bacon","Histamines","Mast Cells"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en","eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2022 Adam Nelczyk"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://hdl.handle.net/2142/117554"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-12-01","The student, Adam Nelczyk, accepted the attached license on 2022-11-16 at 09:10.","The student, Adam Nelczyk, submitted this Dissertation for approval on 2022-11-16 at 09:20.","This Dissertation was approved for publication on 2022-11-21 at 14:11.","DSpace SAF Submission Ingestion Package generated from Vireo submission #18586 on 2023-04-12 at 11:35:01","As the most diagnosed cancer worldwide, breast cancer is one of the most significant modern global public health challenges we currently face. While advances in early detection and therapeutic interventions have improved survivability, this malignancy remains the second leading cause of female cancer-related mortality. This sobering reality highlights an important shortfall in our current approach to breast cancer treatment, which is finding effective therapies for addressing metastatic disease, which is overwhelmingly responsible for the majority of breast cancer deaths. Therefore, this thesis aims to address this lingering issue by focusing on different ends of this deadly cascade. Specifically, in Chapter 1 I review the steps of the metastatic cascade and specific implications for breast cancer. In Chapter 2, I review what is currently known about nuclear receptor TLX (NR2E1), whose dysregulation, overexpression, or loss of expression has been characterized in numerous studies focused on a diverse range of pathological conditions, including cancer. Several studies have described putative synthetic and natural TLX ligands, suggesting that this receptor may serve as a therapeutic target. In Chapter 3, I present data demonstrating that elevated expression of TLX is a positive prognostic indicator in patients with ERα-negative and basal breast cancers, which is further supported by in vitro and in vivo analyses showing that TLX transcriptional regulation impedes the migratory and invasive capacity of triple-negative breast cancer cells. While this addresses the earlier phases of the metastatic cascade, Chapter 4 focuses on a later stage, examining how consumption of fried high-cholesterol food, and alterations to the immune population within the metastatic microenvironment, can promote the “awakening” of dormant tumor cells, one of the final phases of metastatic recurrence. Overall, this thesis takes a two-pronged approach to addressing breast cancer metastasis, providing data that could be used for future therapeutic development as well as lifestyle modification among breast cancer survivors."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Nuclear receptor TLX and dietary habits: Identifying new targets for the treatment and prevention of metastatic breast cancer"]}]}],"canonical_facts":{"dc:contributor":["Nelson, Erik R","Katzenellenbogen, Benita","Spinella, Michael J","Madak-Erdogan, Zeynep"],"dc:creator":["Nelczyk, Adam Tyler"],"dc:date":["2022-12","2022-11-21"],"dc:description":["Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-12-01","The student, Adam Nelczyk, accepted the attached license on 2022-11-16 at 09:10.","The student, Adam Nelczyk, submitted this Dissertation for approval on 2022-11-16 at 09:20.","This Dissertation was approved for publication on 2022-11-21 at 14:11.","DSpace SAF Submission Ingestion Package generated from Vireo submission #18586 on 2023-04-12 at 11:35:01","As the most diagnosed cancer worldwide, breast cancer is one of the most significant modern global public health challenges we currently face. While advances in early detection and therapeutic interventions have improved survivability, this malignancy remains the second leading cause of female cancer-related mortality. This sobering reality highlights an important shortfall in our current approach to breast cancer treatment, which is finding effective therapies for addressing metastatic disease, which is overwhelmingly responsible for the majority of breast cancer deaths. Therefore, this thesis aims to address this lingering issue by focusing on different ends of this deadly cascade. Specifically, in Chapter 1 I review the steps of the metastatic cascade and specific implications for breast cancer. In Chapter 2, I review what is currently known about nuclear receptor TLX (NR2E1), whose dysregulation, overexpression, or loss of expression has been characterized in numerous studies focused on a diverse range of pathological conditions, including cancer. Several studies have described putative synthetic and natural TLX ligands, suggesting that this receptor may serve as a therapeutic target. In Chapter 3, I present data demonstrating that elevated expression of TLX is a positive prognostic indicator in patients with ERα-negative and basal breast cancers, which is further supported by in vitro and in vivo analyses showing that TLX transcriptional regulation impedes the migratory and invasive capacity of triple-negative breast cancer cells. While this addresses the earlier phases of the metastatic cascade, Chapter 4 focuses on a later stage, examining how consumption of fried high-cholesterol food, and alterations to the immune population within the metastatic microenvironment, can promote the “awakening” of dormant tumor cells, one of the final phases of metastatic recurrence. Overall, this thesis takes a two-pronged approach to addressing breast cancer metastasis, providing data that could be used for future therapeutic development as well as lifestyle modification among breast cancer survivors."],"dc:format":["application/pdf"],"dc:identifier":["https://hdl.handle.net/2142/117554"],"dc:language":["en","eng"],"dc:rights":["Copyright 2022 Adam Nelczyk"],"dc:subject":["Nuclear Receptor","Tlx","Nr2e1","Breast Cancer","Metastasis","Tumor Dormancy","High-cholesterol","Cured","Fried","Bacon","Histamines","Mast Cells"],"dc:title":["Nuclear receptor TLX and dietary habits: Identifying new targets for the treatment and prevention of metastatic breast cancer"],"dc:type":["text","Thesis"],"thesis:degree_discipline":["Molecular & Integrative Physi"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:24:56Z"}