{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/116144"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/116144","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Tributyrin supplementation and colitis in young pigs","abstract":"Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-11-15 without embargo terms","abstract_html":"Submission original under an indefinite embargo labeled &#x27;Open Access&#x27;. The submission was exported from vireo on 2022-11-15 without embargo terms","abstract_has_math":false,"creators":["Sommer, Kaitlyn M."],"institution":"University of Illinois at Urbana-Champaign","degree_name":"M.S.","degree_level":"Thesis","degree_discipline":"Animal Sciences","degree_department":null,"school":null,"contributors":["Dilger, Ryan N","Donovan, Sharon M","Swanson, Kelly S"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2022,"date_issued":"2022-08","date_published":"2022-08","updated_at":"2026-07-22T22:24:55Z","subjects":["Tributyrin","DSS","Colitis","Pre-wean","Pig"],"languages":["en","eng"],"rights":["Copyright 2022 Kaitlyn Sommer"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/2142/116144","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Dilger, Ryan N","Donovan, Sharon M","Swanson, Kelly S"]},{"key":"dc:creator","label":"Author","values":["Sommer, Kaitlyn M."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2022-08","2022-05-23"]},{"key":"dc:type","label":"Dc Type","values":["text","Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Animal Sciences"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Tributyrin","DSS","Colitis","Pre-wean","Pig"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en","eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2022 Kaitlyn Sommer"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://hdl.handle.net/2142/116144"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-11-15 without embargo terms","The student, Kaitlyn Sommer, accepted the attached license on 2022-05-16 at 08:50.","The student, Kaitlyn Sommer, submitted this Thesis for approval on 2022-05-16 at 09:09.","This Thesis was approved for publication on 2022-05-23 at 16:37.","DSpace SAF Submission Ingestion Package generated from Vireo submission #18030 on 2022-11-15 at 17:37:26","Non-specific colitis, or grower scours, is a condition in swine causing intestinal inflammation, diarrhea, and growth performance issues. Due to these outcomes, colitis has detrimental economic effects on the pork industry by decreasing the value of the swine and increasing production costs. Organic preventions and treatments are in high demand, but further research is needed to determine their efficacy. As a result, an experiment was conducted to determine the effects of gamma-cyclodextrin encapsulated tributyrin (TBCD), a butyrate conjugate, on pre-wean pigs experiencing dextran sodium sulfate (DSS)-induced colitis. Pigs were weaned from the sow at postnatal day (PND) 2, allotted to a treatment based on litter of origin and body weight, and reared artificially over a 26-d period. Treatments included: 1) Control+NoDSS (nutritionally adequate milk replacer, no DSS), 2) Control+DSS (control diet, plus orally supplemented with 1.25 g/kg BW/d DSS to induce colitis), 3) TBCD+DSS (DSS induction plus diet supplemented with 8.3 g of TBCD per kg of reconstituted milk replacer). Oral administration of DSS occurred from PND 14 to 18. Pig body weight and feed disappearance was measured daily to determine growth performance outcomes. At either PND 27 or 28, pigs were euthanized and serum cytokines (measured as tumor necrosis factor-alpha; TNF-α), intestinal morphology, and volatile fatty acids of luminal contents were evaluated on all pigs. The pigs receiving TBCD+DSS had reduced (P < 0.05) body weight compared with the Control+NoDSS and Control+DSS pigs starting at PND 15 and 17, respectively, and remaining through study completion. Additionally, average daily gain before and after DSS dosing and overall was decreased (P < 0.05) in pigs receiving TBCD+DSS compared with the Control+NoDSS and Control+DSS. Meanwhile, milk disappearance was decreased (P < 0.05) in the TBCD+DSS pigs compared with the Control+NoDSS and Control+DSS groups. However, feed efficiency did not differ across treatments. Further, there was no difference between treatments in serum TNF-α quantified on PND 27 or 28, 10 days post DSS dosing. Regarding tissue effects, oral dosing with DSS increased (P < 0.05) mucosal thickness, or the distance from the lumen to the submucosa, in the distal colon compared with the Control+NoDSS group. Additionally, there were a variety of changes observed in volatile fatty acids, specifically an increase (P < 0.05) in butyrate concentrations in the cecum and proximal colon in TBCD+DSS pigs compared with the Control+NoDSS. Lastly, in all treatments receiving DSS, there was an increase (P < 0.05) in branched-chain fatty acids in the proximal colon. The findings of this research imply that dietary supplementation with TBCD increased butyrate concentrations in colonic contents, though dietary TBCD was unable to mitigate the effects of DSS-induced colitis in young pigs."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Tributyrin supplementation and colitis in young pigs"]}]}],"canonical_facts":{"dc:contributor":["Dilger, Ryan N","Donovan, Sharon M","Swanson, Kelly S"],"dc:creator":["Sommer, Kaitlyn M."],"dc:date":["2022-08","2022-05-23"],"dc:description":["Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-11-15 without embargo terms","The student, Kaitlyn Sommer, accepted the attached license on 2022-05-16 at 08:50.","The student, Kaitlyn Sommer, submitted this Thesis for approval on 2022-05-16 at 09:09.","This Thesis was approved for publication on 2022-05-23 at 16:37.","DSpace SAF Submission Ingestion Package generated from Vireo submission #18030 on 2022-11-15 at 17:37:26","Non-specific colitis, or grower scours, is a condition in swine causing intestinal inflammation, diarrhea, and growth performance issues. Due to these outcomes, colitis has detrimental economic effects on the pork industry by decreasing the value of the swine and increasing production costs. Organic preventions and treatments are in high demand, but further research is needed to determine their efficacy. As a result, an experiment was conducted to determine the effects of gamma-cyclodextrin encapsulated tributyrin (TBCD), a butyrate conjugate, on pre-wean pigs experiencing dextran sodium sulfate (DSS)-induced colitis. Pigs were weaned from the sow at postnatal day (PND) 2, allotted to a treatment based on litter of origin and body weight, and reared artificially over a 26-d period. Treatments included: 1) Control+NoDSS (nutritionally adequate milk replacer, no DSS), 2) Control+DSS (control diet, plus orally supplemented with 1.25 g/kg BW/d DSS to induce colitis), 3) TBCD+DSS (DSS induction plus diet supplemented with 8.3 g of TBCD per kg of reconstituted milk replacer). Oral administration of DSS occurred from PND 14 to 18. Pig body weight and feed disappearance was measured daily to determine growth performance outcomes. At either PND 27 or 28, pigs were euthanized and serum cytokines (measured as tumor necrosis factor-alpha; TNF-α), intestinal morphology, and volatile fatty acids of luminal contents were evaluated on all pigs. The pigs receiving TBCD+DSS had reduced (P < 0.05) body weight compared with the Control+NoDSS and Control+DSS pigs starting at PND 15 and 17, respectively, and remaining through study completion. Additionally, average daily gain before and after DSS dosing and overall was decreased (P < 0.05) in pigs receiving TBCD+DSS compared with the Control+NoDSS and Control+DSS. Meanwhile, milk disappearance was decreased (P < 0.05) in the TBCD+DSS pigs compared with the Control+NoDSS and Control+DSS groups. However, feed efficiency did not differ across treatments. Further, there was no difference between treatments in serum TNF-α quantified on PND 27 or 28, 10 days post DSS dosing. Regarding tissue effects, oral dosing with DSS increased (P < 0.05) mucosal thickness, or the distance from the lumen to the submucosa, in the distal colon compared with the Control+NoDSS group. Additionally, there were a variety of changes observed in volatile fatty acids, specifically an increase (P < 0.05) in butyrate concentrations in the cecum and proximal colon in TBCD+DSS pigs compared with the Control+NoDSS. Lastly, in all treatments receiving DSS, there was an increase (P < 0.05) in branched-chain fatty acids in the proximal colon. The findings of this research imply that dietary supplementation with TBCD increased butyrate concentrations in colonic contents, though dietary TBCD was unable to mitigate the effects of DSS-induced colitis in young pigs."],"dc:format":["application/pdf"],"dc:identifier":["https://hdl.handle.net/2142/116144"],"dc:language":["en","eng"],"dc:rights":["Copyright 2022 Kaitlyn Sommer"],"dc:subject":["Tributyrin","DSS","Colitis","Pre-wean","Pig"],"dc:title":["Tributyrin supplementation and colitis in young pigs"],"dc:type":["text","Thesis"],"thesis:degree_discipline":["Animal Sciences"],"thesis:degree_level":["Thesis"],"thesis:degree_name":["M.S."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:24:55Z"}