{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/116026"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/116026","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Multifunctional nanoparticle-coupled photonic resonator for rapid and digital biosensing","abstract":"Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-08-01","abstract_html":"Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-08-01","abstract_has_math":false,"creators":["Che, Congnyu"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Bioengineering","degree_department":null,"school":null,"contributors":["Cunningham, Brian T","Irudayaraj, Joseph Maria Kumar","Nie, Shuming","Smith, Andrew M."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2022,"date_issued":"2022-08","date_published":"2022-08","updated_at":"2026-07-22T22:24:55Z","subjects":["photonic crystal","magneto-plasmonic nanoparticle","fast digital biosensing","microRNA","antibody detection","multiplex detection"],"languages":["en","eng"],"rights":["Copyright 2022 Congnyu Che"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/2142/116026","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Cunningham, Brian T","Irudayaraj, Joseph Maria Kumar","Nie, Shuming","Smith, Andrew M."]},{"key":"dc:creator","label":"Author","values":["Che, Congnyu"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2022-08","2022-06-22"]},{"key":"dc:type","label":"Dc Type","values":["text","Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Bioengineering"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["photonic crystal","magneto-plasmonic nanoparticle","fast digital biosensing","microRNA","antibody detection","multiplex detection"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en","eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2022 Congnyu Che"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://hdl.handle.net/2142/116026"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-08-01","The student, Congnyu Che, accepted the attached license on 2022-05-29 at 00:19.","The student, Congnyu Che, submitted this Dissertation for approval on 2022-05-31 at 11:44.","This Dissertation was approved for publication on 2022-06-22 at 15:54.","DSpace SAF Submission Ingestion Package generated from Vireo submission #18047 on 2022-11-15 at 19:16:13","The focus of this dissertation is to explore high-sensitivity, rapid, simple, cost-effective, and point-of-care (POC) compatible biomarker quantification approaches by multifunctional nanoparticle (NP)-coupled photonic crystal (PC) biosensors. Utilizing the enhanced absorption of the plasmonic NPs induced by the synergistic plasmonic-photonic coupling, each captured NP on the PC surface can be digitally counted with high signal-to-noise ratio, thus enabling near single-molecule detection of biomarkers. However, the applicability of PC-based approach to POC settings is limited by the mass transport of the analyte or NPs to the PC biosensor surface, which determines the sensitivity and response time of the assay. In this work, I explore two methods of overcoming this limitation: a self-powered microfluidic cartridge and the incorporation of magnetic actuation. First, the design and optimization of microfluidics are investigated to improve surface capture efficiency, followed by a demonstration of HIV antigen quantification assay with a single droplet test sample and femtomolar sensitivity. Next, magneto-plasmonic NPs are leveraged to offer digital microRNA detection and extraordinary testing speed by the dynamic control of nanoparticles. Finally, this work explores minimally invasive multiplexed antibody quantification using a portable imaging platform for POC diagnostics with short sample-to-answer time."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Multifunctional nanoparticle-coupled photonic resonator for rapid and digital biosensing"]}]}],"canonical_facts":{"dc:contributor":["Cunningham, Brian T","Irudayaraj, Joseph Maria Kumar","Nie, Shuming","Smith, Andrew M."],"dc:creator":["Che, Congnyu"],"dc:date":["2022-08","2022-06-22"],"dc:description":["Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-08-01","The student, Congnyu Che, accepted the attached license on 2022-05-29 at 00:19.","The student, Congnyu Che, submitted this Dissertation for approval on 2022-05-31 at 11:44.","This Dissertation was approved for publication on 2022-06-22 at 15:54.","DSpace SAF Submission Ingestion Package generated from Vireo submission #18047 on 2022-11-15 at 19:16:13","The focus of this dissertation is to explore high-sensitivity, rapid, simple, cost-effective, and point-of-care (POC) compatible biomarker quantification approaches by multifunctional nanoparticle (NP)-coupled photonic crystal (PC) biosensors. Utilizing the enhanced absorption of the plasmonic NPs induced by the synergistic plasmonic-photonic coupling, each captured NP on the PC surface can be digitally counted with high signal-to-noise ratio, thus enabling near single-molecule detection of biomarkers. However, the applicability of PC-based approach to POC settings is limited by the mass transport of the analyte or NPs to the PC biosensor surface, which determines the sensitivity and response time of the assay. In this work, I explore two methods of overcoming this limitation: a self-powered microfluidic cartridge and the incorporation of magnetic actuation. First, the design and optimization of microfluidics are investigated to improve surface capture efficiency, followed by a demonstration of HIV antigen quantification assay with a single droplet test sample and femtomolar sensitivity. Next, magneto-plasmonic NPs are leveraged to offer digital microRNA detection and extraordinary testing speed by the dynamic control of nanoparticles. Finally, this work explores minimally invasive multiplexed antibody quantification using a portable imaging platform for POC diagnostics with short sample-to-answer time."],"dc:format":["application/pdf"],"dc:identifier":["https://hdl.handle.net/2142/116026"],"dc:language":["en","eng"],"dc:rights":["Copyright 2022 Congnyu Che"],"dc:subject":["photonic crystal","magneto-plasmonic nanoparticle","fast digital biosensing","microRNA","antibody detection","multiplex detection"],"dc:title":["Multifunctional nanoparticle-coupled photonic resonator for rapid and digital biosensing"],"dc:type":["text","Thesis"],"thesis:degree_discipline":["Bioengineering"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:24:55Z"}