{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/115904"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/115904","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Role of extracellular vesicles(EVs) in mediating cell-to-cell signaling during early pregnancy","abstract":"Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-08-01","abstract_html":"Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-08-01","abstract_has_math":false,"creators":["Ma, Qiuyan"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Molecular & Integrative Physi","degree_department":null,"school":null,"contributors":["Bagchi, Milan K","Bagchi, Indrani C","Nelson, Erik Russell","Raetzman, Lori T","Anakk, Sayeepriyadarsh"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2022,"date_issued":"2022-08","date_published":"2022-08","updated_at":"2026-07-22T22:24:55Z","subjects":["EVs","Decidualization","Pregnancy"],"languages":["en","eng"],"rights":["Copyright 2022 Qiuyan Ma"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/2142/115904","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Bagchi, Milan K","Bagchi, Indrani C","Nelson, Erik Russell","Raetzman, Lori T","Anakk, Sayeepriyadarsh"]},{"key":"dc:creator","label":"Author","values":["Ma, Qiuyan"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2022-08","2022-07-13"]},{"key":"dc:type","label":"Dc Type","values":["text","Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Molecular & Integrative Physi"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["EVs","Decidualization","Pregnancy"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en","eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2022 Qiuyan Ma"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://hdl.handle.net/2142/115904"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-08-01","The student, Qiuyan Ma, accepted the attached license on 2022-07-08 at 14:36.","The student, Qiuyan Ma, submitted this Dissertation for approval on 2022-07-08 at 14:50.","This Dissertation was approved for publication on 2022-07-13 at 13:35.","DSpace SAF Submission Ingestion Package generated from Vireo submission #18191 on 2022-11-16 at 10:18:05","During establishment of pregnancy in humans and rodents, uterine stromal cells secrete various factors that act in an autocrine/paracrine manner to promote their differentiation into decidual cells and facilitate maternal angiogenesis leading to placentation. Signaling factors produced by the decidual cells are relayed to other cells within the uterine milieu to influence dynamic adaptive processes during pregnancy. A major challenge in reproductive sciences today is to decipher the molecular basis of cell-cell communication during early pregnancy. Here, we indicated that hypoxia-inducible factor Hif2α plays an essential role in embryo implantation and decidualization by regulating the expression of Rab27b, a member of the Rab family of GTPases. Rab27b controls the secretion of extracellular vesicles (EVs) that carry mediators of intercellular communication during many physiological processes. The present study showed that primary mouse and human endometrial stromal cells secrete EVs during decidualization and that this process is controlled by a conserved Hif2α - Rab27b pathway. EVs generated by endometrial stromal cells carry a variety of molecular cargoes that augments decidualization, impacts tissue remodeling, stimulates angiogenesis and modulates trophoblast differentiation upon incorporation into recipient cells. Additionally, we analyzed the individual contributions of the potential cargo, specifically GLUT1 and MMP2, that facilitate cell metabolism and tissue remodeling during pregnancy. To our knowledge, this is the first demonstration of the pleiotropic functions of EVs in supporting communication between various cell types within the uterus that is vital in promoting decidualization, angiogenesis and trophoblast development."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Role of extracellular vesicles(EVs) in mediating cell-to-cell signaling during early pregnancy"]}]}],"canonical_facts":{"dc:contributor":["Bagchi, Milan K","Bagchi, Indrani C","Nelson, Erik Russell","Raetzman, Lori T","Anakk, Sayeepriyadarsh"],"dc:creator":["Ma, Qiuyan"],"dc:date":["2022-08","2022-07-13"],"dc:description":["Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-08-01","The student, Qiuyan Ma, accepted the attached license on 2022-07-08 at 14:36.","The student, Qiuyan Ma, submitted this Dissertation for approval on 2022-07-08 at 14:50.","This Dissertation was approved for publication on 2022-07-13 at 13:35.","DSpace SAF Submission Ingestion Package generated from Vireo submission #18191 on 2022-11-16 at 10:18:05","During establishment of pregnancy in humans and rodents, uterine stromal cells secrete various factors that act in an autocrine/paracrine manner to promote their differentiation into decidual cells and facilitate maternal angiogenesis leading to placentation. Signaling factors produced by the decidual cells are relayed to other cells within the uterine milieu to influence dynamic adaptive processes during pregnancy. A major challenge in reproductive sciences today is to decipher the molecular basis of cell-cell communication during early pregnancy. Here, we indicated that hypoxia-inducible factor Hif2α plays an essential role in embryo implantation and decidualization by regulating the expression of Rab27b, a member of the Rab family of GTPases. Rab27b controls the secretion of extracellular vesicles (EVs) that carry mediators of intercellular communication during many physiological processes. The present study showed that primary mouse and human endometrial stromal cells secrete EVs during decidualization and that this process is controlled by a conserved Hif2α - Rab27b pathway. EVs generated by endometrial stromal cells carry a variety of molecular cargoes that augments decidualization, impacts tissue remodeling, stimulates angiogenesis and modulates trophoblast differentiation upon incorporation into recipient cells. Additionally, we analyzed the individual contributions of the potential cargo, specifically GLUT1 and MMP2, that facilitate cell metabolism and tissue remodeling during pregnancy. To our knowledge, this is the first demonstration of the pleiotropic functions of EVs in supporting communication between various cell types within the uterus that is vital in promoting decidualization, angiogenesis and trophoblast development."],"dc:format":["application/pdf"],"dc:identifier":["https://hdl.handle.net/2142/115904"],"dc:language":["en","eng"],"dc:rights":["Copyright 2022 Qiuyan Ma"],"dc:subject":["EVs","Decidualization","Pregnancy"],"dc:title":["Role of extracellular vesicles(EVs) in mediating cell-to-cell signaling during early pregnancy"],"dc:type":["text","Thesis"],"thesis:degree_discipline":["Molecular & Integrative Physi"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:24:55Z"}