{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/115811"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/115811","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"ESWL-Derived Particle Size Distribution and Fracture Geometries: A Contextual GeoBioMed Framework for Assessment of Kidney Stone Recurrence","abstract":"Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-11-14 without embargo terms","abstract_html":"Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-11-14 without embargo terms","abstract_has_math":false,"creators":["Todorov, Lauren G"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"M.S.","degree_level":"Thesis","degree_discipline":"Geology","degree_department":null,"school":null,"contributors":["Fouke, Bruce W"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2022,"date_issued":"2022-05","date_published":"2022-05","updated_at":"2026-07-22T22:24:55Z","subjects":["nephrolithiasis","urolithiasis","mineralogy","stratigraphy","crystalline architecture","extracorporeal shock wave lithotripsy","ESWL","fragments","particles","grain size","reactive surface area","super-resolution autofluorescence","SRAF"],"languages":["en","eng"],"rights":["Copyright 2022 Lauren Todorov"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/2142/115811","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Fouke, Bruce W"]},{"key":"dc:creator","label":"Author","values":["Todorov, Lauren G"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2022-05","2022-04-28"]},{"key":"dc:type","label":"Dc Type","values":["text","Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Geology"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["nephrolithiasis","urolithiasis","mineralogy","stratigraphy","crystalline architecture","extracorporeal shock wave lithotripsy","ESWL","fragments","particles","grain size","reactive surface area","super-resolution autofluorescence","SRAF"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en","eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2022 Lauren Todorov"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://hdl.handle.net/2142/115811"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-11-14 without embargo terms","The student, Lauren Todorov, accepted the attached license on 2022-04-19 at 15:49.","The student, Lauren Todorov, submitted this Thesis for approval on 2022-04-19 at 16:00.","This Thesis was approved for publication on 2022-04-28 at 09:42.","DSpace SAF Submission Ingestion Package generated from Vireo submission #17677 on 2022-11-14 at 17:33:42","Extracorporeal shock wave lithotripsy (ESWL) is a common worldwide clinical treatment for human kidney stones. Yet its 60% success rate is counterbalanced by recurrence rates of 50% within 10 years with no effective treatments currently available. This study has applied GeoBioMed approaches to determine the fracture patterns and grain size distributions of ESWL-derived particles within the context of their original crystalline architecture as revealed by high- and super-resolution autofluorescence (SRAF) microscopy. Calcium oxalate (CaOx) stones were removed from a Mayo Clinic patient using standard percutaneous nephrolithotomy (PCNL) and shock pulse lithotripsy (SPL). This produced ~4-12mm-diameter PCNL-derived fragments that were treated ex vivo to form 100’s of smaller ESWL-derived particles. ESWL-induced fractures propagated in a variety of geometric orientations relative to the original crystalline architecture of each fragment to form rectangular, pointed, concentrically spalled, and irregular, ESWL-derived particles size frequency distributions ranged from very fine silt (4-8m) to very fine pebbles (2-4mm), with a mean of fine sand (125-250m). These particles are smaller than the 3-4mm-diameter detection limit of clinical microcomputed tomography (micro-CT) and are hydrodynamically retained on internal kidney membrane surfaces. ESWL therefore produces small undetectable crystallization seed points distributed throughout the kidney that dramatically increase geochemical reactive surface area and kinetically enhance stone recurrence."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["ESWL-Derived Particle Size Distribution and Fracture Geometries: A Contextual GeoBioMed Framework for Assessment of Kidney Stone Recurrence"]}]}],"canonical_facts":{"dc:contributor":["Fouke, Bruce W"],"dc:creator":["Todorov, Lauren G"],"dc:date":["2022-05","2022-04-28"],"dc:description":["Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-11-14 without embargo terms","The student, Lauren Todorov, accepted the attached license on 2022-04-19 at 15:49.","The student, Lauren Todorov, submitted this Thesis for approval on 2022-04-19 at 16:00.","This Thesis was approved for publication on 2022-04-28 at 09:42.","DSpace SAF Submission Ingestion Package generated from Vireo submission #17677 on 2022-11-14 at 17:33:42","Extracorporeal shock wave lithotripsy (ESWL) is a common worldwide clinical treatment for human kidney stones. Yet its 60% success rate is counterbalanced by recurrence rates of 50% within 10 years with no effective treatments currently available. This study has applied GeoBioMed approaches to determine the fracture patterns and grain size distributions of ESWL-derived particles within the context of their original crystalline architecture as revealed by high- and super-resolution autofluorescence (SRAF) microscopy. Calcium oxalate (CaOx) stones were removed from a Mayo Clinic patient using standard percutaneous nephrolithotomy (PCNL) and shock pulse lithotripsy (SPL). This produced ~4-12mm-diameter PCNL-derived fragments that were treated ex vivo to form 100’s of smaller ESWL-derived particles. ESWL-induced fractures propagated in a variety of geometric orientations relative to the original crystalline architecture of each fragment to form rectangular, pointed, concentrically spalled, and irregular, ESWL-derived particles size frequency distributions ranged from very fine silt (4-8m) to very fine pebbles (2-4mm), with a mean of fine sand (125-250m). These particles are smaller than the 3-4mm-diameter detection limit of clinical microcomputed tomography (micro-CT) and are hydrodynamically retained on internal kidney membrane surfaces. ESWL therefore produces small undetectable crystallization seed points distributed throughout the kidney that dramatically increase geochemical reactive surface area and kinetically enhance stone recurrence."],"dc:format":["application/pdf"],"dc:identifier":["https://hdl.handle.net/2142/115811"],"dc:language":["en","eng"],"dc:rights":["Copyright 2022 Lauren Todorov"],"dc:subject":["nephrolithiasis","urolithiasis","mineralogy","stratigraphy","crystalline architecture","extracorporeal shock wave lithotripsy","ESWL","fragments","particles","grain size","reactive surface area","super-resolution autofluorescence","SRAF"],"dc:title":["ESWL-Derived Particle Size Distribution and Fracture Geometries: A Contextual GeoBioMed Framework for Assessment of Kidney Stone Recurrence"],"dc:type":["text","Thesis"],"thesis:degree_discipline":["Geology"],"thesis:degree_level":["Thesis"],"thesis:degree_name":["M.S."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:24:55Z"}