{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/115810"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/115810","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Individual differences in propensity for resilience: insights from across the genome","abstract":"Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-11-14 without embargo terms","abstract_html":"Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-11-14 without embargo terms","abstract_has_math":false,"creators":["Bucknor, Brianna Alexis"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Psychology","degree_department":null,"school":null,"contributors":["Derringer, Jaime","Briley, Daniel A","Juraska, Janice","Zhao, Sihai","Gobin, Robyn L"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2022,"date_issued":"2022-05","date_published":"2022-05","updated_at":"2026-07-22T22:24:55Z","subjects":["Resilience","Genetics","Psychology","Stress","Trauma"],"languages":["en","eng"],"rights":["Copyright 2022 Brianna Bucknor"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/2142/115810","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Derringer, Jaime","Briley, Daniel A","Juraska, Janice","Zhao, Sihai","Gobin, Robyn L"]},{"key":"dc:creator","label":"Author","values":["Bucknor, Brianna Alexis"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2022-05","2022-04-14"]},{"key":"dc:type","label":"Dc Type","values":["text","Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Psychology"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Resilience","Genetics","Psychology","Stress","Trauma"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en","eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2022 Brianna Bucknor"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://hdl.handle.net/2142/115810"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-11-14 without embargo terms","The student, Brianna Bucknor, accepted the attached license on 2022-04-12 at 23:11.","The student, Brianna Bucknor, submitted this Dissertation for approval on 2022-04-12 at 23:23.","This Dissertation was approved for publication on 2022-04-14 at 16:37.","DSpace SAF Submission Ingestion Package generated from Vireo submission #17647 on 2022-11-14 at 17:33:42","As stress is one of the most consistently identified risk factors for the development of psychopathology—and a normal part of the human condition—there is increased interest in understanding resilience and why individuals differ in their response to trauma. One potential explanation might be found within the genome, as resilience has been identified as being moderately heritable (31-52%). However, the genetic variants underlying the observed heritability are still unknown. To address this gap in knowledge, a robust genome-wide association study (GWAS) of resilience using UK Biobank data (N = 153,625) was performed. Post-GWAS analyses were conducted to gain further insight into the heritability of resilience and the functional consequences of SNPs (single nucleotide polymorphisms) on genes. Results of the GWAS identified one genome-wide significant SNP (rs6096776, : 0.077, P = 1.156 x 10-8) on chromosome 20. However, several reached marginal-significance and were diffuse across the genome, indicating polygenicity. An additive SNP-heritability of 12% was estimated from a variant component analysis. Lastly, functional annotation identified rs6096776 to be intronic on ZFP64. Although ZFP64 has been identified as having clinical relevance, the variant, rs6096776, has not. The results of this work offer further evidence in support of a genetic influence on psychological resilience. While the genome-wide significant variant, rs6096776, did not offer much insight into the mechanism underlying resilience, additional post-GWAS analyses might help to further unravel this association and provide more nuanced insights."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Individual differences in propensity for resilience: insights from across the genome"]}]}],"canonical_facts":{"dc:contributor":["Derringer, Jaime","Briley, Daniel A","Juraska, Janice","Zhao, Sihai","Gobin, Robyn L"],"dc:creator":["Bucknor, Brianna Alexis"],"dc:date":["2022-05","2022-04-14"],"dc:description":["Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-11-14 without embargo terms","The student, Brianna Bucknor, accepted the attached license on 2022-04-12 at 23:11.","The student, Brianna Bucknor, submitted this Dissertation for approval on 2022-04-12 at 23:23.","This Dissertation was approved for publication on 2022-04-14 at 16:37.","DSpace SAF Submission Ingestion Package generated from Vireo submission #17647 on 2022-11-14 at 17:33:42","As stress is one of the most consistently identified risk factors for the development of psychopathology—and a normal part of the human condition—there is increased interest in understanding resilience and why individuals differ in their response to trauma. One potential explanation might be found within the genome, as resilience has been identified as being moderately heritable (31-52%). However, the genetic variants underlying the observed heritability are still unknown. To address this gap in knowledge, a robust genome-wide association study (GWAS) of resilience using UK Biobank data (N = 153,625) was performed. Post-GWAS analyses were conducted to gain further insight into the heritability of resilience and the functional consequences of SNPs (single nucleotide polymorphisms) on genes. Results of the GWAS identified one genome-wide significant SNP (rs6096776, : 0.077, P = 1.156 x 10-8) on chromosome 20. However, several reached marginal-significance and were diffuse across the genome, indicating polygenicity. An additive SNP-heritability of 12% was estimated from a variant component analysis. Lastly, functional annotation identified rs6096776 to be intronic on ZFP64. Although ZFP64 has been identified as having clinical relevance, the variant, rs6096776, has not. The results of this work offer further evidence in support of a genetic influence on psychological resilience. While the genome-wide significant variant, rs6096776, did not offer much insight into the mechanism underlying resilience, additional post-GWAS analyses might help to further unravel this association and provide more nuanced insights."],"dc:format":["application/pdf"],"dc:identifier":["https://hdl.handle.net/2142/115810"],"dc:language":["en","eng"],"dc:rights":["Copyright 2022 Brianna Bucknor"],"dc:subject":["Resilience","Genetics","Psychology","Stress","Trauma"],"dc:title":["Individual differences in propensity for resilience: insights from across the genome"],"dc:type":["text","Thesis"],"thesis:degree_discipline":["Psychology"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:24:55Z"}