{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/115748"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/115748","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Photonic resonator interferometric scattering microscopy","abstract":"Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-05-01","abstract_html":"Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-05-01","abstract_has_math":false,"creators":["Li, Nantao"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Electrical & Computer Engr","degree_department":null,"school":null,"contributors":["Cunningham, Brian T","Gruev, Viktor","Lu, Yi","Zhao, Yang"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2022,"date_issued":"2022-05","date_published":"2022-05","updated_at":"2026-07-22T22:24:55Z","subjects":["Label free","Microscopy","Biosensor","Nanophotonics","Imaging"],"languages":["en","eng"],"rights":["Copyright 2022 Nantao Li"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/2142/115748","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Cunningham, Brian T","Gruev, Viktor","Lu, Yi","Zhao, Yang"]},{"key":"dc:creator","label":"Author","values":["Li, Nantao"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2022-05","2022-04-22"]},{"key":"dc:type","label":"Dc Type","values":["text","Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Electrical & Computer Engr"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Label free","Microscopy","Biosensor","Nanophotonics","Imaging"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en","eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2022 Nantao Li"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://hdl.handle.net/2142/115748"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-05-01","The student, Nantao Li, accepted the attached license on 2022-04-22 at 14:06.","The student, Nantao Li, submitted this Dissertation for approval on 2022-04-22 at 14:12.","This Dissertation was approved for publication on 2022-04-22 at 15:02.","DSpace SAF Submission Ingestion Package generated from Vireo submission #17927 on 2022-11-11 at 12:58:11","The capability to image the species of interest without exogenous labeling with visible light has been one of the central mission for modern optical microscopy. Among the huge variety of photophysical processes in light-matter interaction, elastic scattering is one of the most universal and fundamental phenomena, and thus is an ideal means for optical contrast generation. Recent development in interferometric scattering microscopy has enabled the detection of individual nanoscopic objects as small as single proteins by their elastically scattered light. To push the limit of the smallest detectable features in interferometric imaging system, in this dissertation, we try to address this challenge from the nanophotonic perspective. Specifically, dielectric photonic crystal slabs are designed and utilized as the imaging substrates to improve the imaging sensitivity. First, the delocalized photonic crystal guided resonance can confine light to generate an elevated optical field for the enhanced excitation of elastic scattering light. Additionally, the photonic band edge effect greatly reduces the transmissivity of the incident field, thus resulting in the suppressed background noise and significantly enhanced signal-to-noise ratios. Finally, the far-field angular distribution of the elastic scattered light can be reshaped by the photonic crystal towards smaller numerical aperture, thus allowing for the efficient signal collection by a non-contacting objective. The nanophotonically enhanced imaging platform, named photonic resonator interferometric scattering microscopy, offers a simple and low-cost solution for label-free biosensing for single SARS-CoV-2 viruses and quantitative mass measurement for individual protein molecules."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Photonic resonator interferometric scattering microscopy"]}]}],"canonical_facts":{"dc:contributor":["Cunningham, Brian T","Gruev, Viktor","Lu, Yi","Zhao, Yang"],"dc:creator":["Li, Nantao"],"dc:date":["2022-05","2022-04-22"],"dc:description":["Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-05-01","The student, Nantao Li, accepted the attached license on 2022-04-22 at 14:06.","The student, Nantao Li, submitted this Dissertation for approval on 2022-04-22 at 14:12.","This Dissertation was approved for publication on 2022-04-22 at 15:02.","DSpace SAF Submission Ingestion Package generated from Vireo submission #17927 on 2022-11-11 at 12:58:11","The capability to image the species of interest without exogenous labeling with visible light has been one of the central mission for modern optical microscopy. Among the huge variety of photophysical processes in light-matter interaction, elastic scattering is one of the most universal and fundamental phenomena, and thus is an ideal means for optical contrast generation. Recent development in interferometric scattering microscopy has enabled the detection of individual nanoscopic objects as small as single proteins by their elastically scattered light. To push the limit of the smallest detectable features in interferometric imaging system, in this dissertation, we try to address this challenge from the nanophotonic perspective. Specifically, dielectric photonic crystal slabs are designed and utilized as the imaging substrates to improve the imaging sensitivity. First, the delocalized photonic crystal guided resonance can confine light to generate an elevated optical field for the enhanced excitation of elastic scattering light. Additionally, the photonic band edge effect greatly reduces the transmissivity of the incident field, thus resulting in the suppressed background noise and significantly enhanced signal-to-noise ratios. Finally, the far-field angular distribution of the elastic scattered light can be reshaped by the photonic crystal towards smaller numerical aperture, thus allowing for the efficient signal collection by a non-contacting objective. The nanophotonically enhanced imaging platform, named photonic resonator interferometric scattering microscopy, offers a simple and low-cost solution for label-free biosensing for single SARS-CoV-2 viruses and quantitative mass measurement for individual protein molecules."],"dc:format":["application/pdf"],"dc:identifier":["https://hdl.handle.net/2142/115748"],"dc:language":["en","eng"],"dc:rights":["Copyright 2022 Nantao Li"],"dc:subject":["Label free","Microscopy","Biosensor","Nanophotonics","Imaging"],"dc:title":["Photonic resonator interferometric scattering microscopy"],"dc:type":["text","Thesis"],"thesis:degree_discipline":["Electrical & Computer Engr"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:24:55Z"}