{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/115708"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/115708","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Regulation of skeletal muscle strength adaptations by dietary protein and resistance training in middle adulthood","abstract":"Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-05-01","abstract_html":"Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-05-01","abstract_has_math":false,"creators":["McKenna, Colleen F."],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Nutritional Sciences","degree_department":null,"school":null,"contributors":["Burd, Nicholas A","Khan, Naiman A","Boppart, Marni D","Dilger, Anna C"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2022,"date_issued":"2022-05","date_published":"2022-05","updated_at":"2026-07-22T22:24:55Z","subjects":["aging","exercise training","diet quality"],"languages":["en","eng"],"rights":["Copyright 2022 Colleen F. McKenna"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/2142/115708","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Burd, Nicholas A","Khan, Naiman A","Boppart, Marni D","Dilger, Anna C"]},{"key":"dc:creator","label":"Author","values":["McKenna, Colleen F."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2022-05","2022-04-18"]},{"key":"dc:type","label":"Dc Type","values":["text","Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Nutritional Sciences"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["aging","exercise training","diet quality"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en","eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2022 Colleen F. McKenna"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://hdl.handle.net/2142/115708"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-05-01","The student, Colleen McKenna, accepted the attached license on 2022-04-17 at 12:20.","The student, Colleen McKenna, submitted this Dissertation for approval on 2022-04-17 at 12:34.","This Dissertation was approved for publication on 2022-04-18 at 07:51.","DSpace SAF Submission Ingestion Package generated from Vireo submission #17730 on 2022-11-11 at 12:47:05","Skeletal muscle aging is associated with decreased muscle mass and strength. These factors are a significant contributor to not only physical independence but also chronic disease severity and even mortality. Aging-associated muscle pathology is complex, but it is partly due to dysregulated protein synthesis and oxidative status. Given the complexity of muscle dysfunction with advancing age, it may be prudent to explore lifestyle strategies and therapeutic targets that impact a variety of aging-associated pathologies to effectively maintain muscle quality. Middle adulthood is a key life stage to implement these strategies as a preventative measure to maximize the healthspan. The scientific consensus for dietary protein needs to support resistance training (1.6 g·kg-1·d-1) extrapolate total dietary needs from supplementation studies, disregarding the role of protein timing and quality. Accordingly, more thorough dietary control is required to address this question appropriately. Likewise, molecular therapeutic targets known to interact with both protein synthesis and redox pathways in preclinical models have not been corroborated in humans. The purpose of the studies in this dissertation was to examine how dietary protein and resistance training contribute to healthy aging from the perspective of skeletal muscle. This objective was achieved through a dietary counseling-controlled resistance training intervention in middle-aged adults assessing strength, lean mass, cardiometabolic biomarkers, and skeletal muscle tissue at baseline and after the 10-week intervention. In study I, we demonstrated that a high protein diet (~1.68 g·kg-1·d-1) does not potentiate resistance training-induced strength and lean mass gains in comparison to a moderate protein diet (~1.16 g·kg-1·d-1) in middle-aged adults. Furthermore, diets rich in high-quality animal protein foods were shown to not affect cardiometabolic disease risk when consumed during a resistance training program. In study II, we showed that resistance training increased molecular mediators of hypertrophy and oxidative function as well as mitochondrial respiratory capacity, which corresponded to strength gains. The studies in this dissertation demonstrated that the strategic consumption (e.g., high-quality sources during anabolic feeding windows) of moderate amounts of protein is sufficient to maximize strength and lean mass gains with resistance training. Moreover, strength adaptations with resistance training correspond to molecular mediators of healthy skeletal muscle aging."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Regulation of skeletal muscle strength adaptations by dietary protein and resistance training in middle adulthood"]}]}],"canonical_facts":{"dc:contributor":["Burd, Nicholas A","Khan, Naiman A","Boppart, Marni D","Dilger, Anna C"],"dc:creator":["McKenna, Colleen F."],"dc:date":["2022-05","2022-04-18"],"dc:description":["Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-05-01","The student, Colleen McKenna, accepted the attached license on 2022-04-17 at 12:20.","The student, Colleen McKenna, submitted this Dissertation for approval on 2022-04-17 at 12:34.","This Dissertation was approved for publication on 2022-04-18 at 07:51.","DSpace SAF Submission Ingestion Package generated from Vireo submission #17730 on 2022-11-11 at 12:47:05","Skeletal muscle aging is associated with decreased muscle mass and strength. These factors are a significant contributor to not only physical independence but also chronic disease severity and even mortality. Aging-associated muscle pathology is complex, but it is partly due to dysregulated protein synthesis and oxidative status. Given the complexity of muscle dysfunction with advancing age, it may be prudent to explore lifestyle strategies and therapeutic targets that impact a variety of aging-associated pathologies to effectively maintain muscle quality. Middle adulthood is a key life stage to implement these strategies as a preventative measure to maximize the healthspan. The scientific consensus for dietary protein needs to support resistance training (1.6 g·kg-1·d-1) extrapolate total dietary needs from supplementation studies, disregarding the role of protein timing and quality. Accordingly, more thorough dietary control is required to address this question appropriately. Likewise, molecular therapeutic targets known to interact with both protein synthesis and redox pathways in preclinical models have not been corroborated in humans. The purpose of the studies in this dissertation was to examine how dietary protein and resistance training contribute to healthy aging from the perspective of skeletal muscle. This objective was achieved through a dietary counseling-controlled resistance training intervention in middle-aged adults assessing strength, lean mass, cardiometabolic biomarkers, and skeletal muscle tissue at baseline and after the 10-week intervention. In study I, we demonstrated that a high protein diet (~1.68 g·kg-1·d-1) does not potentiate resistance training-induced strength and lean mass gains in comparison to a moderate protein diet (~1.16 g·kg-1·d-1) in middle-aged adults. Furthermore, diets rich in high-quality animal protein foods were shown to not affect cardiometabolic disease risk when consumed during a resistance training program. In study II, we showed that resistance training increased molecular mediators of hypertrophy and oxidative function as well as mitochondrial respiratory capacity, which corresponded to strength gains. The studies in this dissertation demonstrated that the strategic consumption (e.g., high-quality sources during anabolic feeding windows) of moderate amounts of protein is sufficient to maximize strength and lean mass gains with resistance training. Moreover, strength adaptations with resistance training correspond to molecular mediators of healthy skeletal muscle aging."],"dc:format":["application/pdf"],"dc:identifier":["https://hdl.handle.net/2142/115708"],"dc:language":["en","eng"],"dc:rights":["Copyright 2022 Colleen F. McKenna"],"dc:subject":["aging","exercise training","diet quality"],"dc:title":["Regulation of skeletal muscle strength adaptations by dietary protein and resistance training in middle adulthood"],"dc:type":["text","Thesis"],"thesis:degree_discipline":["Nutritional Sciences"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:24:55Z"}