{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/115699"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/115699","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Modeling and simulation of intrinsically disordered biomolecular systems","abstract":"Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-05-01","abstract_html":"Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-05-01","abstract_has_math":false,"creators":["Chou, Han-Yi"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Physics","degree_department":null,"school":null,"contributors":["Aksimentiev, Aleksei","Tajkhorshid, Emad","Luthey-Schulten, Zaida Ann","Sing, Charles E."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2022,"date_issued":"2022-05","date_published":"2022-05","updated_at":"2026-07-22T22:24:55Z","subjects":["coarse-grained simulation","molecular dynamics simulation","liquid-liquid phase separation","percolation transition","nuclear pore complex","single-stranded binding protein."],"languages":["en","eng"],"rights":["Copyright 2022 Han-Yi Chou"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/2142/115699","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Aksimentiev, Aleksei","Tajkhorshid, Emad","Luthey-Schulten, Zaida Ann","Sing, Charles E."]},{"key":"dc:creator","label":"Author","values":["Chou, Han-Yi"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2022-05","2022-04-15"]},{"key":"dc:type","label":"Dc Type","values":["text","Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Physics"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["coarse-grained simulation","molecular dynamics simulation","liquid-liquid phase separation","percolation transition","nuclear pore complex","single-stranded binding protein."]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en","eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2022 Han-Yi Chou"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://hdl.handle.net/2142/115699"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-05-01","The student, Han-Yi Chou, accepted the attached license on 2022-04-14 at 10:31.","The student, Han-Yi Chou, submitted this Dissertation for approval on 2022-04-14 at 11:08.","This Dissertation was approved for publication on 2022-04-15 at 09:12.","DSpace SAF Submission Ingestion Package generated from Vireo submission #17668 on 2022-11-11 at 12:19:13","The conventional sequence-structure-functionality paradigm relates the molecular structures uniquely to the biological functionalities. Recently, this paradigm has been complemented by a new perspective as overwhelming experimental evidence reveals the significant roles of intrinsically disordered molecules in multiple biological functions. Despite of advancement in modern laboratory equipments and techniques, simulation and theoretical modeling remain valuable and serve as complementary tools for they are able to probe into details and to provide explanations for experimental observations. In this dissertation, simulation and modeling were combined to investigate intrinsically disordered molecules in various biological systems. Our research provides detailed descriptions and theoretical models for multiple intrinsically disordered molecules which are vital in cellular functions."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Modeling and simulation of intrinsically disordered biomolecular systems"]}]}],"canonical_facts":{"dc:contributor":["Aksimentiev, Aleksei","Tajkhorshid, Emad","Luthey-Schulten, Zaida Ann","Sing, Charles E."],"dc:creator":["Chou, Han-Yi"],"dc:date":["2022-05","2022-04-15"],"dc:description":["Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-05-01","The student, Han-Yi Chou, accepted the attached license on 2022-04-14 at 10:31.","The student, Han-Yi Chou, submitted this Dissertation for approval on 2022-04-14 at 11:08.","This Dissertation was approved for publication on 2022-04-15 at 09:12.","DSpace SAF Submission Ingestion Package generated from Vireo submission #17668 on 2022-11-11 at 12:19:13","The conventional sequence-structure-functionality paradigm relates the molecular structures uniquely to the biological functionalities. Recently, this paradigm has been complemented by a new perspective as overwhelming experimental evidence reveals the significant roles of intrinsically disordered molecules in multiple biological functions. Despite of advancement in modern laboratory equipments and techniques, simulation and theoretical modeling remain valuable and serve as complementary tools for they are able to probe into details and to provide explanations for experimental observations. In this dissertation, simulation and modeling were combined to investigate intrinsically disordered molecules in various biological systems. Our research provides detailed descriptions and theoretical models for multiple intrinsically disordered molecules which are vital in cellular functions."],"dc:format":["application/pdf"],"dc:identifier":["https://hdl.handle.net/2142/115699"],"dc:language":["en","eng"],"dc:rights":["Copyright 2022 Han-Yi Chou"],"dc:subject":["coarse-grained simulation","molecular dynamics simulation","liquid-liquid phase separation","percolation transition","nuclear pore complex","single-stranded binding protein."],"dc:title":["Modeling and simulation of intrinsically disordered biomolecular systems"],"dc:type":["text","Thesis"],"thesis:degree_discipline":["Physics"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:24:55Z"}