{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/115680"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/115680","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Mechanisms underlying uterine function during establishment of pregnancy","abstract":"Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-05-01","abstract_html":"Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-05-01","abstract_has_math":false,"creators":["Porter, Kevin William"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"M.S.","degree_level":"Thesis","degree_discipline":"VMS - Comparative Biosciences","degree_department":null,"school":null,"contributors":["Bagchi, Indrani C","Bagchi, Milan","Flaws, Jodi"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2022,"date_issued":"2022-05","date_published":"2022-05","updated_at":"2026-07-22T22:24:55Z","subjects":["Uterus","Pregnancy","Glucose Transport","Glucose Metabolism","Gestational Diabetes Mellitus","Glut1","Glucose Transporter 1","Phthalates","endocrine-disrupting chemicals","Fertility"],"languages":["en","eng"],"rights":["Copyright 2022 Kevin Porter"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/2142/115680","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Bagchi, Indrani C","Bagchi, Milan","Flaws, Jodi"]},{"key":"dc:creator","label":"Author","values":["Porter, Kevin William"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2022-05","2022-04-17"]},{"key":"dc:type","label":"Dc Type","values":["text","Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["VMS - Comparative Biosciences"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Uterus","Pregnancy","Glucose Transport","Glucose Metabolism","Gestational Diabetes Mellitus","Glut1","Glucose Transporter 1","Phthalates","endocrine-disrupting chemicals","Fertility"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en","eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2022 Kevin Porter"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://hdl.handle.net/2142/115680"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-05-01","The student, Kevin Porter, accepted the attached license on 2022-03-30 at 15:30.","The student, Kevin Porter, submitted this Thesis for approval on 2022-03-30 at 15:50.","This Thesis was approved for publication on 2022-04-17 at 13:12.","DSpace SAF Submission Ingestion Package generated from Vireo submission #17564 on 2022-11-11 at 12:18:52","Pregnancy is an extremely complex condition with many processes and steps that need to occur for it to be successful. It is clear that many different problems can arise during pregnancy that can lead to a miscarriage. The reasons for many of these miscarriages remain unknown. Understanding these problems and the underlying mechanisms is important to increase the success of pregnancy and decrease the incidence of miscarriage. A major process for successful pregnancy is maternal glucose metabolism. It is known that this metabolism in the mother helps to assist in the proper development and growth of the fetus. Changes in this metabolism, whether that be increases or decreases, can cause major problems for the maternal-fetal unit including spontaneous abortion and intrauterine growth restrictions for the fetus. Glucose transporter 1 is the predominant glucose transporter of the body controlling glucose homeostasis of most tissues, including the uterine endometrium. Investigating the effects of this glucose transporter in the uterus and pregnancy can shed light on the problems that lessened concentrations of this transporter can have on the success of pregnancy or pregnancy-associated diseases such as Gestational Diabetes Mellitus. Another issue that can adversely impact establishment and maintenance of pregnancy is the exposure of the fetus and the mother to endocrine disrupting chemicals such as phthalates. Phthalates are used as plasticizers in many consumer products. These chemicals have been found to have many negative effects on the reproductive system. However, the effect of these chemicals on the uterus remains largely unknown. Thus, understanding the changes that occur in the uterus due to exposure of these chemicals will significantly advance our understanding of the impact these chemicals on the female reproductive system."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Mechanisms underlying uterine function during establishment of pregnancy"]}]}],"canonical_facts":{"dc:contributor":["Bagchi, Indrani C","Bagchi, Milan","Flaws, Jodi"],"dc:creator":["Porter, Kevin William"],"dc:date":["2022-05","2022-04-17"],"dc:description":["Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-05-01","The student, Kevin Porter, accepted the attached license on 2022-03-30 at 15:30.","The student, Kevin Porter, submitted this Thesis for approval on 2022-03-30 at 15:50.","This Thesis was approved for publication on 2022-04-17 at 13:12.","DSpace SAF Submission Ingestion Package generated from Vireo submission #17564 on 2022-11-11 at 12:18:52","Pregnancy is an extremely complex condition with many processes and steps that need to occur for it to be successful. It is clear that many different problems can arise during pregnancy that can lead to a miscarriage. The reasons for many of these miscarriages remain unknown. Understanding these problems and the underlying mechanisms is important to increase the success of pregnancy and decrease the incidence of miscarriage. A major process for successful pregnancy is maternal glucose metabolism. It is known that this metabolism in the mother helps to assist in the proper development and growth of the fetus. Changes in this metabolism, whether that be increases or decreases, can cause major problems for the maternal-fetal unit including spontaneous abortion and intrauterine growth restrictions for the fetus. Glucose transporter 1 is the predominant glucose transporter of the body controlling glucose homeostasis of most tissues, including the uterine endometrium. Investigating the effects of this glucose transporter in the uterus and pregnancy can shed light on the problems that lessened concentrations of this transporter can have on the success of pregnancy or pregnancy-associated diseases such as Gestational Diabetes Mellitus. Another issue that can adversely impact establishment and maintenance of pregnancy is the exposure of the fetus and the mother to endocrine disrupting chemicals such as phthalates. Phthalates are used as plasticizers in many consumer products. These chemicals have been found to have many negative effects on the reproductive system. However, the effect of these chemicals on the uterus remains largely unknown. Thus, understanding the changes that occur in the uterus due to exposure of these chemicals will significantly advance our understanding of the impact these chemicals on the female reproductive system."],"dc:format":["application/pdf"],"dc:identifier":["https://hdl.handle.net/2142/115680"],"dc:language":["en","eng"],"dc:rights":["Copyright 2022 Kevin Porter"],"dc:subject":["Uterus","Pregnancy","Glucose Transport","Glucose Metabolism","Gestational Diabetes Mellitus","Glut1","Glucose Transporter 1","Phthalates","endocrine-disrupting chemicals","Fertility"],"dc:title":["Mechanisms underlying uterine function during establishment of pregnancy"],"dc:type":["text","Thesis"],"thesis:degree_discipline":["VMS - Comparative Biosciences"],"thesis:degree_level":["Thesis"],"thesis:degree_name":["M.S."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:24:55Z"}