{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/115597"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/115597","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Chip-scale diffraction phase microscopy","abstract":"Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-05-01","abstract_html":"Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-05-01","abstract_has_math":false,"creators":["Edwards, Lonna D"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Electrical & Computer Engr","degree_department":null,"school":null,"contributors":["Goddard, Lynford","Li, Xiuling","Alleyne, Andrew","Gruev, Viktor"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2022,"date_issued":"2022-05","date_published":"2022-05","updated_at":"2026-07-22T22:24:54Z","subjects":["diffraction phase microscopy","phase contrast microscopy","interferometry","Fresnel lens","chip-scale"],"languages":["en","eng"],"rights":["Copyright 2022 Lonna D. Edwards"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/2142/115597","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Goddard, Lynford","Li, Xiuling","Alleyne, Andrew","Gruev, Viktor"]},{"key":"dc:creator","label":"Author","values":["Edwards, Lonna D"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2022-05","2022-04-22"]},{"key":"dc:type","label":"Dc Type","values":["text","Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Electrical & Computer Engr"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["diffraction phase microscopy","phase contrast microscopy","interferometry","Fresnel lens","chip-scale"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en","eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2022 Lonna D. Edwards"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://hdl.handle.net/2142/115597"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-05-01","The student, Lonna Edwards, accepted the attached license on 2022-04-21 at 15:43.","The student, Lonna Edwards, submitted this Dissertation for approval on 2022-04-21 at 15:55.","This Dissertation was approved for publication on 2022-04-22 at 09:57.","DSpace SAF Submission Ingestion Package generated from Vireo submission #17890 on 2022-11-11 at 12:11:45","The invention of the bright-field microscope helped scientists image cells as early as the seventeenth century; however, it was not until the 1930’s when Fritz Zernike invented the phase contrast microscope that transparent objects could be imaged without labeling. With the invention of photodetectors, quantitative phase imaging (QPI) developed, bringing with it sensitive and quick measurements containing height and refractive index analyses. Additionally, non-invasive imaging of transparent samples became possible. Though numerous QPI methods exist, diffraction phase microscopy (DPM) is notably advantageous. Its benefits include: 1) noise cancellation, 2) the ability to noninvasively image diverse samples, and 3) fast image acquisition. Due to its success in many applications, including cell imaging and semiconductor metrology, the author proposes scaling down the macro-scale system to implement the Mach-Zehnder-based interferometer on-chip. An on-chip model introduces additional advantages, including 1) space-saving properties, 2) reduction in material consumption and, thus, the cost of the optical system, and 3) reduction in the alignment error of the system. DPM on-chip also has the potential to be used in a new application: portable microscopy. If DPM on-chip is integrated as an add-on module to a cellphone camera, the image processing could be executed within a cellphone application. Such a system might prove useful in biological labs with limited space for testing instruments. It might also be beneficial in biology classrooms that attempt to spark curiosity within younger citizen scientists. The author will present optimized design parameters, fabrication techniques for key components, and potential applications for the device given its reduced field-of-view. Final results of the optimized system will be discussed followed by an explanation of future work that seeks to improve the outcome."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Chip-scale diffraction phase microscopy"]}]}],"canonical_facts":{"dc:contributor":["Goddard, Lynford","Li, Xiuling","Alleyne, Andrew","Gruev, Viktor"],"dc:creator":["Edwards, Lonna D"],"dc:date":["2022-05","2022-04-22"],"dc:description":["Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-05-01","The student, Lonna Edwards, accepted the attached license on 2022-04-21 at 15:43.","The student, Lonna Edwards, submitted this Dissertation for approval on 2022-04-21 at 15:55.","This Dissertation was approved for publication on 2022-04-22 at 09:57.","DSpace SAF Submission Ingestion Package generated from Vireo submission #17890 on 2022-11-11 at 12:11:45","The invention of the bright-field microscope helped scientists image cells as early as the seventeenth century; however, it was not until the 1930’s when Fritz Zernike invented the phase contrast microscope that transparent objects could be imaged without labeling. With the invention of photodetectors, quantitative phase imaging (QPI) developed, bringing with it sensitive and quick measurements containing height and refractive index analyses. Additionally, non-invasive imaging of transparent samples became possible. Though numerous QPI methods exist, diffraction phase microscopy (DPM) is notably advantageous. Its benefits include: 1) noise cancellation, 2) the ability to noninvasively image diverse samples, and 3) fast image acquisition. Due to its success in many applications, including cell imaging and semiconductor metrology, the author proposes scaling down the macro-scale system to implement the Mach-Zehnder-based interferometer on-chip. An on-chip model introduces additional advantages, including 1) space-saving properties, 2) reduction in material consumption and, thus, the cost of the optical system, and 3) reduction in the alignment error of the system. DPM on-chip also has the potential to be used in a new application: portable microscopy. If DPM on-chip is integrated as an add-on module to a cellphone camera, the image processing could be executed within a cellphone application. Such a system might prove useful in biological labs with limited space for testing instruments. It might also be beneficial in biology classrooms that attempt to spark curiosity within younger citizen scientists. The author will present optimized design parameters, fabrication techniques for key components, and potential applications for the device given its reduced field-of-view. Final results of the optimized system will be discussed followed by an explanation of future work that seeks to improve the outcome."],"dc:format":["application/pdf"],"dc:identifier":["https://hdl.handle.net/2142/115597"],"dc:language":["en","eng"],"dc:rights":["Copyright 2022 Lonna D. Edwards"],"dc:subject":["diffraction phase microscopy","phase contrast microscopy","interferometry","Fresnel lens","chip-scale"],"dc:title":["Chip-scale diffraction phase microscopy"],"dc:type":["text","Thesis"],"thesis:degree_discipline":["Electrical & Computer Engr"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:24:54Z"}